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Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer被引量：17
《National Science Review》2019年第1期101-108,共8页Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060100 to Q.S.,XDB32060200 to H-C.C.and 32070100to M-m.P.);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to Q.S.,Z.L.,H-C.C.and M-m.P.);the Shanghai Municipal Government Bureau of Science and Technology(18JC1410100 to Q.S.,H-C.C.and M-m.P.);the Ministry of Science and Technology(973 Program,2011CBA00400);the Institute of Neuroscience Director’s Fund(to M-m.P.);the National Postdoctoral Program for Innovative Talents(to Z.L.);the National Key Research and Development Program of China(2018YFC1003000 to Q.S.and Z.L.);the National Natural Science Foundation of China Grant(31825018to Q.S.)
Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. He...
关键词：MACAQUE monkey CLONING SOMATIC cell nuclear transfer non-human PRIMATE models CRISPR/Cas9 GENE editing CIRCADIAN rhythm disorders 
Polycomb-group histone methyltransferase CLF is required for proper somatic recombination in Arabidopsis
《Journal of Integrative Plant Biology》2014年第6期550-558,共9页Na Chen Wang-Bin Zhou Ying-Xiang Wang Ai-Wu Dong Yu Yu 
supported by the National Basic Research Program of China (973 Program, grants nos. 2012CB910500 and 2011CB944600);the National Natural Science Foundation of China (31371304)
Homologous recombination （HR） is a key process during meiosis in reproductive cells and the DNA damage repair process in somatic cells. Although chromatin structure is thought to be crucial for HR, only a smal numbe...
关键词：ARABIDOPSIS CLF DNA repair homologous recombination MEIOSIS 
Induced pluripotency and direct reprogramming:a new window for treatment of neurodegenerative diseases被引量：1
《Protein & Cell》2013年第6期415-424,共10页Rui Li Ye Bai Tongtong Liu Xiaoqun Wang Qian Wu 
the National Basic Research Program 973 program(No.2012CB966800);the Thousand Youth Talents Program and the Pioneer Programs of Chinese Academy of Sciences。
Human embryonic stem cells(hESCs)are pluripotent cells that have the ability of unlimited self-renewal and can be differentiated into different cell lineages,includ-ing neural stem(NS)cells.Diverse regulatory signalin...
关键词：human embryonic stem cells(hESCs) neu-ronal differentiation induced pluripotent stem cells(iPSCs) somatic direct reprogramming lineage reprogramming regen-erative medicine 
Current progress and prospects of induced pluripotent stem cells被引量：11
《Science China(Life Sciences)》2009年第7期622-636,共15页CHEN LingYi & Liu Lin Key Laboratory of Bioactive Materials of Ministry of Education,College of Life Sciences,Nankai University,Tianjin 300071,China 
Supported by the National Key Basic Research and Development Program of China (Grant No. 2009CB941000);the Ministry of Science and Technology of China, and the transgenic program (Grant No. 2009ZX08006-010B);the National Natural Science Foundation of China (Grant No. 90919009);the Ministry of Agriculture of China (Grant No. 2009ZX08006-011B)
Induced pluripotent stem(iPS) cells are derived from somatic cells by ectopic expression of few transcription factors.Like embryonic stem(ES) cells,iPS cells are able to self-renew indefinitely and to differentiate in...
关键词：induced PLURIPOTENT stem(iPS) cells SOMATIC cell REPROGRAMMING PLURIPOTENCY 
Effects of different nuclear recipients on developmental potential of mouse somatic nuclear transfer embryos
《Chinese Science Bulletin》2003年第5期469-471,共3页LEILei LIUZhonghua ZHUZiyu KOUZhaohui WUYuqi XUYing WENDuancheng BIChunming XIAGuoliang CHENDayuan 
the Climbing Project of the Ministry of Science and Technology of China (Grant No. 97021109-2) and the Major Project of Knowledge Innovation of the Chinese Academy of Sciences (Grant No. KSCX1-05-01)
In order to investigate the effects of different kinds of nuclear recipients from Kunming (KM) mouse on developmental potential of somatic nuclear transfer em- bryos, the enucleated MⅡ oocytes, enucleated zygotes and...
关键词：昆明鼠 体细胞 核移植 晶胚 核受体 发育潜力 
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