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Utilizing Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)in hypothesis-driven queries: 《Neural Regeneration Research》2026年第2期677-678,共2页Diana Acosta Cankun Wang Qin Ma Hongjun Fu; Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...; 关键词：sex specific alzheimer s disease ad deciphering molecular mechanisms spatial transcriptomics ssread spatial transcriptomics st Alzheimers disease single cell RNA seq

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord: 《Neural Regeneration Research》2025年第11期3302-3316,共15页Yali Chen Yiyong Wei Jin Liu Tao Zhu Cheng Zhou Donghang Zhang; supported by the National Natural Science Foundation of China,No.82301403(to DZ)。; Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocyt...; 关键词：astrocyte glial cell HUMAN microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Integrated spatial priority assessment in Central Asia:Bridging biodiversity,ecosystem services,and human activities: 《Geography and Sustainability》2025年第2期194-208,共15页Shiran Song Xi Chen Chanjuan Zan Hao Zhang Chuan Wang Zengyun Hu Yaoming Li; funded by the Joint CAS-MPG Research Project(HZXM20225001MI);this research was also supported partly by the key program of National Natural Science Foundation of China(42230708);the Tianshan Talent Project of Xinjiang Uygur Autonomous Region,China(2022TSYCLJ0056).; Central Asia(CA)faces escalating threats from increasing temperature,glacier retreat,biodiversity loss,unsustainable water use,terminal lake shrinkage,and soil salinization,all of which challenge the balance between e...; 关键词：Spatially priority assessment BIODIVERSITY Ecosystem services Human activities Central Asia

Single-cell and spatial omics:exploring hypothalamic heterogeneity: 《Neural Regeneration Research》2025年第6期1525-1540,共16页Muhammad Junaid Eun Jeong Lee Su Bin Lim; supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI);the Ministry of Health&Welfare,Republic of Korea (HR22C1734);the National Research Foundation (NRF) of Korea (2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)(to SBL);the NRF of Korea (2022R1C1C1005741 and RS-2023-00217595);the new faculty research fund of Ajou University School of Medicine (to EJL)。; Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technolo...; 关键词：cellular diversity HYPOTHALAMUS multi-omics single-cell transcriptomics spatial transcriptomics

NH_(4)^(+)-Modulated Cathodic Interfacial Spatial Charge Redistribution for High-Performance Dual-Ion Capacitors: 《Nano-Micro Letters》2025年第5期391-406,共16页Yumin Chen Ziyang Song Yaokang Lv Lihua Gan Mingxian Liu; financially supported by the National Natural Science Foundation of China(Nos.22272118,22172111 and 22309134);the Science and Technology Commission of Shanghai Municipality,China(Nos.22ZR1464100,20ZR1460300 and 19DZ2271500);China Postdoctoral Science Foundation(2022M712402);Shanghai Rising-Star Program(23YF1449200);Zhejiang Provincial Science and Technology Project(2022C01182);the Fundamental Research Funds for the Central Universities(22120210529 and 2023-3-YB-07)。; Compared with Zn^(2+),the current mainly reported charge carrier for zinc hybrid capacitors,small-hydrated-sized and light-weight NH_(4)^(+)is expected as a better one to mediate cathodic interfacial electrochemical b...; 关键词：NH_(4)^(+)-modulated cathodic interface Spatial charge redistribution Zn^(2+)/NH_(4)^(+) co-storage Dual-ion capacitor

Dynamic Spatial Focus in Alzheimer’s Disease Diagnosis via Multiple CNN Architectures and Dynamic GradNet: 《Computers, Materials & Continua》2025年第5期2109-2142,共34页Jasem Almotiri; funded by Taif University,Saudi Arabia;The author would like to acknowledge Deanship of Graduate Studies and Scientific Research,Taif University for funding this work.; The evolving field of Alzheimer’s disease(AD)diagnosis has greatly benefited from deep learning models for analyzing brain magnetic resonance(MR)images.This study introduces Dynamic GradNet,a novel deep learning mode...; 关键词：Spatial focus GradCAM medical image classification deep learning early dementia detection neurodegenerative disease MRI analysis Alzheimer’s attention CNN

Spatial Random Effects Improve the Predictions of Multispecies Distribution in a Marine Fish Assemblage: 《Journal of Ocean University of China》2025年第2期471-482,共12页XU Tianheng ZHANG Chongliang XU Binduo XUE Ying JI Yupeng REN Yiping; supported by the National Key R&D Program of China(No.2022YFD2401301)。; Species distribution patterns is one of the important topics in ecology and biological conservation.Although species distribution models have been intensively used in the research,the effects of spatial associations a...; 关键词：HMSC spatial autocorrelation JSDM sample size PREDICTABILITY

Phase distortion correction of fringe patterns in spaceborne Doppler asymmetric spatial heterodyne interferometry: 《中国光学(中英文)》2025年第2期382-392,共11页PEI Hui-yi JIANG Lun WANG Jin-jiang CUI Yong FANG Yuan-xiang ZHANG Jia-ming CHEN Ci; 吉林省科技发展计划项目(No.20230201006GX)。; As an advanced device for observing atmospheric winds,the spaceborne Doppler Asymmetric Spatial Heterodyne(DASH)interferometer also encounters challenges associated with phase distortion,par-ticularly in limb sounding...; 关键词：Doppler asymmetric spatial heterodyne spectroscopy phase distortion phase inversion atmospheric wind measurement

Features of the spatial and seasonal distribution of hydrocarbons in water of the North Crimean Canal,Crimea: 《Acta Geochimica》2025年第2期247-259,共13页O.V.Soloveva E.A.Tikhonova N.Yu.Mirzoeva; This work has been supported by the Russian Science Foundation;Project No.23-26-00128,“The role of the North Crimean Canal irrigation system in the processes of transfer of long-lived radionuclides of the Chernobyl origin,heavy metals,as well as hydrocarbons with the Dnieper water to the irrigated farmlands of Crimea”。; The North Crimean Canal is a watercourse originating from the Kakhovka Reservoir and flowing into the Crimean Peninsula.The canal is an important source of drinking water supply and is also used to irrigate agricultur...; 关键词：Aliphatic hydrocarbons N-ALKANES WATER Indexes North Crimean canal CRIMEA

Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids: 《World Journal of Gastrointestinal Surgery》2025年第4期333-346,共14页Min-Hui Ke Shu-Yan Huang Wei-Gan Lin Zhen-Guo Xu Xia-Xia Zheng Xian-Bao Liu You-Min Cheng Zuan-Fang Li; Supported by the National Natural Science Foundation of China,No.81774118;the Foreign Cooperation Project of Science and Technology Department of Fujian Province,No.2023I0021;the Medical Innovation Project of Fujian Province,No.2024CXB013.; BACKGROUND Hemorrhoids,a prevalent chronic condition globally,significantly impact patients'quality of life.While various surgical interventions,such as external stripping and internal ligation,procedure for prolapse ...; 关键词：Internal hemorrhoids Xiaozhiling injection FIBROBLAST Marker gene Single-cell sequencing Spatial transcriptome sequencing

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