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STIMULATION: 作品数：830被引量：1650H指数：16; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王志功吕晓迎杨丹蕾李超乾张珍祥更多>>; 相关机构：华中科技大学复旦大学广州市妇女儿童医疗中心中国人民解放军总医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate被引量：4: 《Cell Research》2022年第3期288-301,共14页Ao Hu Jing-Zan Zhang Jie Wang Chen-Chen Li Meng Yuan Gang Deng Zi-Cun Lin Zhi-Ping Qiu Hu-Yue Liu Xian-Wei Wang Peng-Cheng Wei Xiao He Xiaolu Zhao Wen-Wei Qiu Bao-Liang Song; We thank Ms.Dan Liang for technical assitance,Dr.Wei Qi(ShanghaiTech University)for revising the manuscript.We appreciate the helpful discussion with Drs.Guo-Yin Yin Wuhan University)and Yun Zhao(Shanghail Istitutes for Biological Sciences);This work was supported by grants from the National Natural Science Foundation of China(22077035,91753204,31690102,91957103);Ministry of Science and Technology of China(2018YF A0800700.2019YFA0802701);Fountain-Valley Life Sciences Fund of University of Chinese Academy of Sciences Education Foundation.B.-L.S.acknowledges the support from the Tencent Foundation through the XPLORER PRIZE.; Hedgehog(Hh)is a morphogen that binds to its receptor Patched 1 and activates Smoothened(SMO),thereby governing embryonic development and postnatal tissue homeostasis.Cholesterol can bind and covalently conjugate to t...; 关键词：SMOOTHENED CHOLESTEROL STIMULATION

Functional Near-Infrared Spectroscopy Neurofeedback of Cortical Target Enhances Hippocampal Activation and Memory Performance被引量：4: 《Neuroscience Bulletin》2021年第8期1251-1255,共5页Xin Hou Xiang Xiao Yilong Gong Yihan Jiang Peipei Sun Juan Li Zheng Li Xiaojie Zhao Li Yao Antao Chen Chaozhe Zhu; the National Natural Science Foundation of China(82071999,61431002,31521063,and 61273287);the National 973 Program(2014CB846100).; Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain f...; 关键词：STIMULATION INFRARED attracting

Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition被引量：9: 《Cell Research》2019年第11期895-910,共16页Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan; This work was supported by Ministry of Science and Technology of China(2018YFA0800200 and 2017YF0503600);National Natural Science Foundation of China(31571505 and 31371461),CAS Strategic Priority Research Program(XDB19030000);Scientific Research Equipment Development Project(YZ201646)to WJP.; The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic fa...; 关键词：STIMULATION VEGFA metabolism

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc被引量：4: 《Cellular & Molecular Immunology》2019年第9期757-769,共13页Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su; This study was partially supported by grant PR093728(DoD to B.S.);the National Natural Science Foundation of China(grant numbers 31470845 and 81430033 to B.S.,31422020 to F.L.and 31600704 to H.H.Z.);grant 13JC1404700 from the Program of Science and Technology Commission of Shanghai Municipality(B.S.);the Ministry of Science and Technology of China(Program 2014CB943600,F.L.);Chinese Mega Project on Infectious Diseases(No.2018ZX10302301).; Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2...; 关键词：METABOLISM IMMUNITY STIMULATION

Anodal Transcranial Direct-Current Stimulation Over the Right Dorsolateral Prefrontal Cortex Influences Emotional Face Perception被引量：3: 《Neuroscience Bulletin》2018年第5期842-848,共7页Li-Chuan Yang Ping Ren Yuan-Ye Ma; supported by the National Natural Science Foundation of China (91132302, 31730039);Ministry of Science and Technology of China (2015CB351701).; The dorsolateral prefrontal cortex （DLPFC） is considered to play a crucial role in many high-level functions, such as cognitive control and emotional regula- tion. Many studies have reported that the DLPFC can be ac...; 关键词：TDCS Facial expression EMOTION Dorso-lateral prefrontal cortex

Characterization of a Thermophilic Monosaccharide Stimulated β-Giucosidase from Acidothermus cellulolyticus被引量：1: 《Chemical Research in Chinese Universities》2018年第2期212-220,共9页LI Yuwei BU Mingwei CHEN Peng LI Xiaohong CHEN Changwu GAO Gui FENG Yan HAN Weiwei ZHANG Zuoming; The gene（ABK51908） from Acidothermus cellulolyncus encodes a mature protein of 484 residues with a calculated molecular mass of 53.0 kDa. Sequence analysis revealed that the protein had 59% identity to the β-glucos...; 关键词：β-Glueosidase Monosaccharide-stimulation Salt tolerance Thermophilic enzyme

Neurons generated from carcinoma stem cells support cancerprogression被引量：1: 《Signal Transduction and Targeted Therapy》2017年第1期320-329,共10页Ran Lu Chuanwen Fan Wenqi Shangguan Yuan Liu Yu Li Yanna Shang Dongqin Yin Shengliang Zhang Qiaorong Huang Xue Li Wentong Meng Hong Xu Zongguang Zhou Jiankun Hu Weimin Li Lunxu Liu Xianming Mo; This work was supported by the National Basic Research Program of China(to XM 2015CB942800);the Nature Science Foundation of China(to XM 81361120381;to CF 81402446).; Recent evidences show that nervous system acts as a crucial part of cancer microenvironment.Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression.The stimulations...; 关键词：CANCER inhibited STIMULATION

Somato Stimulation and Acupuncture Therapy被引量：2: 《Chinese Journal of Integrative Medicine》2016年第5期394-400,共7页赵敬军荣培晶石力贲卉朱兵; Supported by the National Basic Research Program of China(973 Program,No.012CB518503);Key Program of National Natural Science Foundation of China,(No.81130063); Acupuncture is an oldest somato stimulus medical technique. As the most representative peripheral nerve stimulation therapy, it has a complete system of theory and application and is applicable to a large population. ...; 关键词：somato stimulus ACUPUNCTURE mechanism of action

The progress in optic nerve regeneration, where are we?被引量：4: 《Neural Regeneration Research》2016年第1期32-36,共5页Jennifer Wei Huen Shum Kai Liu Kwok-fai So; supported by National Program on Key Basic Research Project of China(973 Program;2011CB707501);Funds of Leading Talents of Guangdong(2013);Program of Introducing Talents of Discipline to Universities(B14036); Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are ma...; 关键词：optic nerve regeneration axonal regeneration neurotrophic factor inflammatory stimulation nerve bridging substances

Effect of electronic stimulation at Neiguan(PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia被引量：5: 《Journal of Traditional Chinese Medicine》2015年第5期577-582,共6页Wang Wei Li Jiquan Meng Xiangyu Chen Yiguo; Supported by National Basic Research Program of China(973 Program);Study on Biological Foundation of Response in Target Organ to Meridian Specificity of Acupoint Effect(No.2012CB518503); OBJECTIVE:To investigate the effects of electronic stimulation at acupoints Neiguan(PC 6) and Lieque(LU 7) on the gene expression of the adenosine triphosphate(ATP)-Sensitive potassium channel(KATP:Kir6.1,Kir6.2,SUR2 ...; 关键词：Point PC6（Neiguan） Acupuncture Electric stimulation KATP Channels Protein Kinases Myocardial ischemia

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