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SYSTEMS_BIOLOGY: 作品数：154被引量：434H指数：9; 导出分析报告; 相关作者：陈铭平艳艳张子丁肖云李鑫更多>>; 相关机构：浙江大学信息科学与技术学院中国医学科学院北京协和医学院北京师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金福建省自然科学基金更多>>

Big data and artificial intelligence-aided crop breeding:Progress and prospects: 《Journal of Integrative Plant Biology》2025年第3期722-739,共18页Wanchao Zhu Weifu Li Hongwei Zhang Lin Li; supported by the National Key Research and Development Program of China (2023YFF1000100) (to L.L. and W.L.);the National Natural Science Foundation of China (32321005) (to L.L.)。; The past decade has witnessed rapid developments in gene discovery, biological big data(BBD),artificial intelligence(AI)-aided technologies, and molecular breeding. These advancements are expected to accelerate crop b...; 关键词：artificial intelligence biological big data BREEDING precision design breeding systems biology

Exploration of compatibility rules and discovery of active ingredients in TCM formulas by network pharmacology: 《Chinese Herbal Medicines》2024年第4期572-588,共17页Yishu Liu Xue Li Chao Chen Nan Ding Shiyu Ma Ming Yang; supported by Natural Science Foundation of Shanghai (No. 22ZR1462100);Shanghai Municipal Education Commission Collaborative Innovation Center, Clinical Evaluation Platform for Traditional Chinese Medicine and Chinese Patent Medicine (No. A1-U21-205-902);Long Hua Hospital Research Projects (No. YM2021016 and RC-2020-02-04);Shanghai Sailing Program (No. 22YF1440300);Shanghai ‘‘Rising Stars of Medical Talents” Youth Development Program (Clinical Pharmacist Program), Shanghai Jiaotong University ‘‘Jiaotong University Star” Program (medical-engineering cross-research, No. YG2022QN015);Shanghai Flagship Hospital of Traditional Chinese and Western Medicine [No. ZY(2021-2023)-0205-01];Shanghai Traditional Chinese Medicine Colorectal Cancer Speciality Alliance [No. ZY(20212023)-0302];Shanghai Municipal Health Commission Project (No. 2020LZ007);Traditional Chinese Medicine Research Project of Shanghai Health Commission (No. 2022QN097);Demonstration-oriented Research Ward Construction Project of Shanghai Hospital Development Center (No. SHDC2022CRW006)。; Network pharmacology is an interdisciplinary field that utilizes computer science, technology, and biological networks to investigate the intricate interplay among compounds/ingredients, targets, and diseases. Within ...; 关键词：active ingredients compatibility rules molecular mechanism network analysis network pharmacology systems biology target prediction traditional chinese medicine

Omics big data for crop improvement:Opportunities and challenges: 《The Crop Journal》2024年第6期1517-1532,共16页Naresh Vasupalli Javaid Akhter Bhat Priyanka Jain Tanu Sri Md Aminul Islam SMShivaraj Sunil Kumar Singh Rupesh Deshmukh Humira Sonah Xinchun Lin; Fund for International Young Scientists by the National Natural Science Foundation of China (32150410354)to Naresh Vasupalli;the Department of Biotechnology,Government of India,for the Ramalingaswami Fellowship Award (BT/PR38279/GET/119/351/2020)to Humira Sonah;Haryana State Council for Science Innovation and Technology (HSCSIT)for the research grant PI ID 1270,HSCSIT/R&D/2024/511 to Rupesh Deshmukh and Humira Sonah.; The application of advanced omics technologies in plant science has generated an enormous dataset of sequences,expression profiles,and phenotypic traits,collectively termed“big data”for their significant volume,dive...; 关键词：Big data GWAS WGRS qQTL TWAS Systems biology CRISPR/Cas9

Stress Knowledge Map:A knowledge graph resource for systems biology analysis of plant stress responses: 《Plant Communications》2024年第6期17-31,共15页Carissa Bleker Ziva Ramsak Andras Bittner Vid Podpecan Maja Zagorscak Bernhard Wurzinger Spela Baebler Marko Petek Maja Kriznik Annelotte van Dieren Juliane Gruber Leila Afjehi-Sadat Wolfram Weckwerth Anze Zupanic Markus Teige Ute CVothknecht Kristina Gruden; funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement 862858(ADAPT);the Slovenian Research Agency under grant agreements 1000-15-0105,Z7-1888,J4-1777,P4-0165,N4-0199,Z4-50146,and J4-3089;ELIXIR,the research infrastructure for life science data through the ELIXIR Implementation Study“Increasing plant data findability for ELIXIR and beyond”and ELIXIR-SI.We gratefully acknowledge funding from the Deutsche Forschungsgemeinschaft(DFG)to U.C.V.(INST 217/939-1 FUGG).; Stress Knowledge Map(SKM;https://skm.nib.si)is a publicly available resource containing two complementary knowledge graphs that describe the current knowledge of biochemical,signaling,and regulatory molecular interact...; 关键词：knowledge graph plant stress responses plant signaling systems biology plant digital twin

Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood: 《四川生理科学杂志》2024年第5期1111-1111,共1页Nikolaos P Daskalakis; The molecular pathology of stress-related disorders remains elusive.Our brain multiregion,multiomic study of posttraumatic stress disorder(PTSD)and major depressive disorder(MDD)included the central nucleus of the amy...; 关键词：structure. CORTEX MEDIAL

Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model被引量：1: 《Journal of Pharmaceutical Analysis》2024年第4期585-600,共16页Yuanyuan Qian Xiting Wang Lulu Cai Jiangxue Han Zhu Huang Yahui Lou Bingyue Zhang Yanjie Wang Xiaoning Sun Yan Zhang Aisong Zhu; supported by the National Natural Science Foundation of China(Grant No.:82174246);the National Key R&D Program of China(Grant No.:2019YFC1708701);the Postdoctoral Innovation Talent Support Program(Grant No.:BX20220329).; Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex diseases.To characterize the precise syndromes,precise diseases and precise targets of the precise targets ...; 关键词：Chinese herbal medicine formulas Precision medicine Mathematical modeling Systems biology Coronary heart disease Depression ISCHEMIA-REPERFUSION Inflammation

Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens: 《Plant Communications》2024年第1期55-68,共14页Antoni Garcia-Molina Victoria Pastor; funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no.101028809 (AG-M);from project RTI2018-094350-B-C33 funded by the Spanish Ministry for Science,Innovation and Universities (VP);from grants SEV-2015-0533 and CEX2019-000902-S funded by MCIN/AEI/10.13039/501100011033;from the CERCA Programme/Generalitat de Catalunya.; Understanding plant immune responses is complex because of the high interdependence among biological processes in homeostatic networks.Hence,the integration of environmental cues causes network rewiring that interfere...; 关键词：abiotic stress ARABIDOPSIS biotic stress combinatorial stress metabolomics systems biology

A basic phosphoproteomic-DIA workflow integrating precise quantification of phosphosites in systems biology: 《Biophysics Reports》2023年第2期82-98,共17页Yi Di Wenxue Li Barbora Salovska Qian Ba Zhenyi Hu Shisheng Wang Yansheng Liu; Phosphorylation is one of the most important post-translational modifications(PTMs)of proteins,governing critical protein functions.Most human proteins have been shown to undergo phosphorylation,and phosphoproteomic s...; 关键词：Bioinformatic analysis High-resolution mass spectrometry technology PHOSPHOPROTEOMICS Systems biology Systems medicine

Multiscale mathematical models for biological systems被引量：1: 《Frontiers of Mathematics in China》2023年第2期75-94,共20页Xiaoqiang SUN Jiguang BAO; the National Natural Science Foundation of China(Grant Nos.62273364,11871070&11371060);the Guangdong Basic and Applied Basic Research Foundation(2020B1515020047).; Life activities are extremely complex phenomena in nature.From molecular signaling regulation to multi-cellular tissue formation and so on,the biological system consists of multiple temporal,spatial and functional sca...; 关键词：Multi-scale model partial differential equations agent-based model systems biology

Design and construction of microbial cell factories based on systems biology被引量：2: 《Synthetic and Systems Biotechnology》2023年第1期176-185,共10页Wenlong Yan Zhibei Cao Mingzhu Ding Yingjin Yuan; by the National Key Research and Development Program of China (2019YFA0706900);National Natural Science Foundation of China (22278310).; Environmental sustainability is an increasingly important issue in industry.As an environmentally friendly and sustainable way,constructing microbial cell factories to produce all kinds of valuable products has attrac...; 关键词：Microbial cell factories Systems biology Functional genes/enzymes discovery Bottleneck pathways Strains tolerance Synthetic microbial consortia

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