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Senescence-targeted MicroRNA/Organoid composite hydrogel repair cartilage defect and prevention joint degeneration via improved chondrocyte homeostasis被引量：2
《Bioactive Materials》2024年第9期427-442,共16页Ye Sun Yongqing You Qiang Wu Rui Hu Kerong Dai 
funded by the China National Natural Science Funds(No.82172446).We are also grateful for the help and advice from Professor Kerong Dai from Shanghai Ninth People’s Hospital,Shanghai Jiaotong University。
Introduction:Cartilage defect(CD)is a common complication in osteoarthritis(OA).Impairment of chondrogenesis and cellular senescence are considered as hallmarks of OA development and caused failure of cartilage repair...
关键词：CARTILAGE DEGENERATION CHONDROCYTE 
MMP13-targeted siRNA-loaded micelles for diagnosis and treatment of posttraumatic osteoarthritis
《Bioactive Materials》2024年第7期378-392,共15页Dongyang Zhou Yan Wei Shihao Sheng Miaomiao Wang Jiajing Lv Bowen Zhao Xiao Chen Ke Xu Long Bai Yan Wu Peiran Song Liehu Cao Fengjin Zhou Hao Zhang Zhongmin Shi Jiacan Su 
supported by Integrated Project of Major Research Plan of National Natural Science Foundation of China (92249303);National Natural Science Foundation of China (82230071,82172098,82371603,82102217,81872428,and 81703010);the Shanghai Rising Star Program (21QA1412000);Shanghai Hospital Development Center (SHDC2023CRT013);Shanghai Committee of Science and Technology (23141900600,Laboratory Animal Research Project);Shanghai Baoshan District Medical Health Project (21-E-14);the Construction of Key Medical Disciplines of Baoshan District of Shanghai (BSZK-2023-Z07);the Shanghai Municipal Natural Science Foundation (23ZR1463300);Postdoctoral Fellowship Program of CPSF (GZB20230397);General Funding for China Postdoctoral Science Foundation (2023M732179).
Posttraumatic osteoarthritis(PTOA)patients are often diagnosed by X-ray imaging at a middle-late stage when drug interventions are less effective.Early PTOA is characterized by overexpressed matrix metalloprotease 13(...
关键词：Early-stage posttraumatic osteoarthritis(PTOA) Matrix metalloprotease 13(MMP 13) Micelles Fluorescence imaging siRNA delivery 
Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis被引量：3
《Bioactive Materials》2024年第2期427-444,共18页Jiaqi Xu Chaoran Shi Feifei Yuan Yinghe Ding Yong Xie Yudong Liu Fengzhang Zhu Hongbin Lu Chunyue Duan Jianzhong Hu Liyuan Jiang 
supported by the Key Program of the National Natural Science Foundation of China(No.82030071);the National Natural Science Foundation of China(No.82202722,No.81874004);the Science and Technology Major Project of Changsha(No.kh2103008);the Science Foundation of Xiangya Hospital for Young Scholar(Grant No.2021q18);the Natural Science Foundation of Changsha city(Grant No.kq2202378);Graduate students of Central South University independently explore innovative projects(2022ZZTS094).
Mitochondria are crucial in sustaining and orchestrating cellular functions.Capitalizing on this,we explored mitochondrial transplantation as an innovative therapeutic strategy for acute spinal cord injury(SCI).In our...
关键词：Spinal cord injury(SCI) Mitochondrial transplantation MACROPHAGE PHAGOCYTOSIS Targeted therapy 
A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy被引量：4
《Bioactive Materials》2023年第9期337-347,共11页Bin Xu Fanjun Zeng Jialong Deng Lintong Yao Shengbo Liu Hengliang Hou Yucheng Huang Hongyuan Zhu Shaowei Wu Qiaxuan Li Weijie Zhan Hongrui Qiu Huili Wang Yundong Li Xianzhu Yang Ziyang Cao Yu Zhang Haiyu Zhou 
supported by the National Key R&D Program of China(No.2022YFD2401900);the National Natural Science Foundation of China(No.52203163);the High-level Hospital Construction Project(No.DFJH201905);the Natural Science Foundation of Guangdong(No.2021A1515010838);the International Science and Technology Cooperation Program of Guangdong(No.2022A0505050048);the Science and Technology Program of Guangzhou(No.201903010028);Guangdong Provincial People’s Hospital Intermural Program(No.KJ012019447).
The abnormal activation of epidermal growth factor receptor(EGFR)drives the development of non-small cell lung cancer(NSCLC).The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically tr...
关键词：Biomimetic nanoparticles Membrane targeting EGFR mutation Tyrosine kinase inhibitor Intracellular drug delivery Clinical efficacy Non-small cell lung cancer 
Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury被引量：5
《Bioactive Materials》2023年第7期766-782,共17页Ning Ran Wenxiang Li Renjie Zhang Caorui Lin Jianping Zhang Zhijian Wei Zonghao Li Zhongze Yuan Min Wang Baoyou Fan Wenyuan Shen Xueying Li Hengxing Zhou Xue Yao Xiaohong Kong Shiqing Feng 
This work was supported by the National Key Research and Development Project of Stem Cell and Transformation Research(2019YFA0112100),China;National Natural Science Foundation of China(81930070);National Natural Science Foundation of China(82102560);the Natural Science Foundation of Shandong Province,China(ZR2021QH097);the No.69 General Fund of China Postdoctoral Science Foundation(2021M691936);Talent project of Shandong University(22480082063100),China.
Spinal cord injury(SCI)causes motor,sensory and automatic impairment due to rarely axon regeneration.Developing effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal rege...
关键词：Spinal cord injury Targeted repair Autologous plasma exosome Drug loading Axon regeneration 
Functionalized liposomes for targeted breast cancer drug delivery被引量：4
《Bioactive Materials》2023年第6期401-437,共37页Janske Nel Kamil Elkhoury Émilie Velot Arnaud Bianchi Samir Acherar Grégory Francius Ali Tamayol Stéphanie Grandemange Elmira Arab-Tehrany 
Despite the exceptional progress in breast cancer pathogenesis,prognosis,diagnosis,and treatment strategies,it remains a prominent cause of female mortality worldwide.Additionally,although chemotherapies are effective...
关键词：Liposomes Breast cancer Anti-cancer agents Targeted drug delivery Surface functionalization Receptor-targeted drug delivery 
Bone/cartilage targeted hydrogel: Strategies and applications被引量：11
《Bioactive Materials》2023年第5期156-169,共14页Hao Zhang Shunli Wu Weikai Chen Yan Hu Zhen Geng Jiacan Su 
This work was funded by the National Key R&D Program of China(2018YFC2001500);Key Project of The National Natural Science Foundation of China(82230071);National Natural Science Foundation of China(82172098,32101084).
The skeletal system is responsible for weight-bearing,organ protection,and movement.Bone diseases caused by trauma,infection,and aging can seriously affect a patient’s quality of life.Bone targeted biomaterials are s...
关键词：BONE CARTILAGE HYDROGEL Target therapy Bone disease 
Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors
《Bioactive Materials》2023年第5期508-523,共16页Tao Chen Yucheng Xue Shengdong Wang Jinwei Lu Hao Zhou Wenkan Zhang Zhiyi Zhou Binghao Li Yong Li Zenan Wang Changwei Li Yinwang Eloy Hangxiang Sun Yihang Shen Mohamed Diaty Diarra Chang Ge Xupeng Chai Haochen Mou Peng Lin Xiaohua Yu Zhaoming Ye 
This work was supported by National Natural Science Foundation of China(81872173,82072959,31870959,and 82102855);Zhejiang Province Natural Science Foundation(LY20H160018,LD21H160002,and LY19H160045).
Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy(ACT)against solid tumors.Here,we present a facile immune cell surface engineering strategy aiming to substantia...
关键词：Adoptive cell therapy(ACT) Phage display Cell surface engineering Th9 cell Solid tumor 
Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury被引量：6
《Bioactive Materials》2023年第5期328-342,共15页Yuluo Rong Zhuanghui Wang Pengyu Tang Jiaxing Wang Chengyue Ji Jie Chang Yufeng Zhu Wu Ye Jianling Bai Wei Liu Guoyong Yin Lipeng Yu Xuhui Zhou Weihua Cai 
This work was sponsored by the National Natural Science Foundation of China(grant No.81974335,82172426).We would like to thank the Core Facility of the First Affiliated Hospital of Nanjing Medical University for its help in the experiment.
Spinal cord injury(SCI)is a severe disease of the nervous system that causes irreparable damage and loss of function,for which no effective treatments are available to date.Engineered extracellular vesicles(EVs)carryi...
关键词：Extracellular vesicles Spinal cord injury SIRNA Microglia/macrophages polarization Induced neural stem cells 
Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment被引量：3
《Bioactive Materials》2023年第3期381-393,共13页Qiong Huang Yuqi Yang Tianjiao Zhao Qiaohui Chen Min Liu Shuting Ji Yan Zhu Yunrong Yang Jinping Zhang Haixin Zhao Yayun Nan Kelong Ai 
National Natural Science Foundation of China(No.81974508,21974134);Hunan Science Fund for Distinguished Young Scholar of China(No.2021JJ10067);Innovation-Driven Project of Central South University(No.202045005);Hunan Provincial Natural Science Foundation of China(No.2021JJ31066);Key Research Project of Ningxia Hui Autonomous Region in 2021 of China(Major Project)(No.2021BEG01001);Key Program of Ningxia Hui Autonomous Region Natural Science Foundation of China(No.2022JJ21059).
Acute kidney injury(AKI)can lead to loss of kidney function and a substantial increase in mortality.The burst of reactive oxygen species(ROS)plays a key role in the pathological progression of AKI.Mitochondrial-target...
关键词：ROS-scavenging Anti-inflammatory Acute kidney injury Passively-targeted mitochondrial Tungsten-Based Nanodots 
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