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作品数:1877被引量:2864H指数:19
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相关领域:医药卫生更多>>
相关作者:高栓虎张志毅林善枝温春燕徐海斌更多>>
相关机构:中国科学院北京大学清华大学中国农业大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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  • 期刊=Chinese Chemical Lettersx
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Total synthesis of(+)-taberdicatine B and(+)-tabernabovine B
《Chinese Chemical Letters》2025年第2期321-325,共5页Tengfei Xuan Xinyu Zhang Wei Han Yidong Huang Weiwu Ren 
the Qingdao Marine Science and Technology Center(No.2022QNLM030003-2);the Fundamental Research Funds for the Central Universities,Taishan Scholar Program of Shandong Province(No.tsqn202103152);National Natural Science Foundation of China(No.22171251) for financial support。
The first total synthesis of(+)-taberdicatine B and(+)-tabernabovine B has been accomplished in 10steps with 26.9% overall yield and 15 steps with 7.3% overall yield,respectively.The prominent features of this efficie...
关键词:Taberdicatine B Tabernabovine B Hexahydropyrrolo[2 3-b]indole Asymmetric dearomatization Total synthesis 
Divergent total synthesis of marine meroterpenoids(+)-dysidavarones A–C
《Chinese Chemical Letters》2024年第3期234-238,共5页Qunlong Zhang Yang Kuang Le Chang Jingyi Kang Bingjian Wang Chuanke Chong Zhaoyong Lu 
financially supported by the National Natural Science Foundation of China(Nos.22171146,21971121,and 22188101 to ZL);the China Postdoctoral Science Foundation(No.2021M701775 to CC)。
Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–C(1–3)using predysidavarone 6 as a key common intermediate.The highly straine...
关键词:Total synthesis Natural product Dysidavarones A–C Sesquiterpene quinone Meroterpenoid 
Total chemical synthesis of bivalently modified H3 by improved three-segment native chemical ligation
《Chinese Chemical Letters》2020年第5期1267-1270,共4页Yong Zheng Fangming Wu Shenglong Ling Jia-Bin Li Changlin Tian 
supported by the National Natural Science Foundation of China(Nos.21708036,31470740,U1732161);Anhui Provincial Natural Science Foundation (No.1808085QC63)。
The H3 bivalent modifications of trimethylationat Lys9 and acetylation at Lys18(H3-K9 Me3-K18 Ac) were identified to collectively recruit TRIM33 in the nodal signaling pathway.To understand the underlying mechanism of...
关键词:Chemical protein synthesis Native chemical ligation Histone H3 METHYLATION ACETYLATION Nucleosome core particles 
Seven-step total synthesis of α-cyclopiazonic acid
《Chinese Chemical Letters》2020年第2期401-403,共3页Shibin Shi Kuo Yuan Yanxing Jia 
supported by the National Natural Science Foundation of China(No.21871013);the Drug Innovation Major Project(No.2018ZX09711-001-005-005)。
A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulati...
关键词:INDOLE ALKALOIDS TOTAL synthesis CASCADE CYCLIZATION NATURAL products 
Total synthesis of TRADD death domain with arginine N-GlcNAcylation by hydrazide-based native chemical ligation
《Chinese Chemical Letters》2020年第1期107-110,共4页Ye Wu Yulei Li Wei Cong Yan Zou Xiang Li Honggang Hu 
the National Natural Science Foundation of China (Nos.91849129,21807112);PLA Youth Medical Science and Technology Youth Development Program (No.16QNP086);Foundation of Second Military Medical University (No.2016JS11)
TNFR1-associated death domain protein(TRADD)with arginine N-GlcNAcylation is a novel and structurally unique posttranslational modification(PTM)glycoprotein that blocks the formation of death-inducing signaling comple...
关键词:TRADD death domain Posttranslational modification Protein chemical synthesis Solid-phase peptide synthesis Native chemical ligation Peptide hydrazide 
Total syntheses of dehydrobotrydienal, dehydrobotrydienol and 10-oxodehydrodihydrobotrydial
《Chinese Chemical Letters》2019年第8期1503-1505,共3页Zichun Zhang Dandan Zhao Yingdong He Zhen Yang Jianxian Gong 
supported by the National Natural Science Foundation of China (Nos. 21772008, 21632002 and U1606403);Natural Science Foundation of Guangdong Province (No. 2016A030306011);Shenzhen Basic Research Program (Nos. JCYJ20170818090044432 and JCYJ20160226105337556);Qingdao National Laboratory for Marine Science and Technology (No. LMDBKF201703)
In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiou...
关键词:TOTAL SYNTHESIS Botryanes Pauson-Khand REACTION Electrocyclic REACTIONS NATURAL PRODUCTS 
An alternative total synthesis of bolivianine被引量:1
《Chinese Chemical Letters》2017年第1期113-116,共4页Jin-Peng Li Chang-Chun Yuan Biao Du Bo Liu 
the National Natural Science Foundation of China (Nos. 21322205, 21321061);the Ministry of Education of China (No. 20130181110022)
An alternative total synthesis of bolivianine in twelve steps is herein reported on the basis of our previous successful bioinspired total synthesis. The present total synthesis features straightforward transformation...
关键词:Total synthesis CYCLOPROPANATION AldolDiels-Alder Terpeniod 
Total synthesis of norleucosceptroids F and G被引量:1
《Chinese Chemical Letters》2015年第11期1341-1344,共4页Jiao Xu Bo Liu 
financial support from the National Natural Science Foundation of China(Nos.21322205,21321061,J1103315);the Ministry of Education of China(No.20130181110022)
First total synthesis of norleucosceptroids F and G has been achieved through key steps of Michael-AIdol cascade, oxa-Michael cyclization-dehydration-deprotection cascade and cross metathesis (CM), this work develop...
关键词:Total synthesisNorleucosceptroid FNorleucosceptroid G 
First total synthesis of natural products cajanolactone A and cajanonic acid A被引量:7
《Chinese Chemical Letters》2014年第5期749-751,共3页Wen-Zhang Chen Ling-Ling Fan Hai-Tao Xiao Ying Zhou Wan Xiao Jian-Ta Wang Lei Tang 
supported by the National Natural Science Foundation of China (Nos. 21102025 and 81360470);Program for New Century Excellent Talents in University (No. NCET-120656)
First total synthesis of cajanolactone A and cajanonic acid A has been achieved through steps of anion–anion condensations,cyclization,Williams etherification,selective demethylation,1 3-sigmatropic rearrangement and...
关键词:Total synthesis Cajanolactone A Cajanonic acid A 
First total synthesis of (±)-malaysianone A and (±)-tanariflavanones B被引量:4
《Chinese Chemical Letters》2013年第11期1027-1029,共3页Jin-Hui Yang Bing-Bing Chen Yi-Min Xie Yao Feng Xiao-Qin Ma 
financially supported by the National Natural Science Foundation (Nos. 21162021, 20962016);the Program for New Century Excellent Talents in University (No. NCET-090860)
A concise approach for the frst total synthesis of two naturally occurring flavanoids,()-malaysianone A(1)and()-tanariflavanones B(2),has been accomplished with total yields of 12.9%and 10.4%,respectively.The ...
关键词:Malaysianone A Tanariflavanones B Total synthesis Flavanoids 
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