the Qingdao Marine Science and Technology Center(No.2022QNLM030003-2);the Fundamental Research Funds for the Central Universities,Taishan Scholar Program of Shandong Province(No.tsqn202103152);National Natural Science Foundation of China(No.22171251) for financial support。
The first total synthesis of(+)-taberdicatine B and(+)-tabernabovine B has been accomplished in 10steps with 26.9% overall yield and 15 steps with 7.3% overall yield,respectively.The prominent features of this efficie...
financially supported by the National Natural Science Foundation of China(Nos.22171146,21971121,and 22188101 to ZL);the China Postdoctoral Science Foundation(No.2021M701775 to CC)。
Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–C(1–3)using predysidavarone 6 as a key common intermediate.The highly straine...
supported by the National Natural Science Foundation of China(Nos.21708036,31470740,U1732161);Anhui Provincial Natural Science Foundation (No.1808085QC63)。
The H3 bivalent modifications of trimethylationat Lys9 and acetylation at Lys18(H3-K9 Me3-K18 Ac) were identified to collectively recruit TRIM33 in the nodal signaling pathway.To understand the underlying mechanism of...
supported by the National Natural Science Foundation of China(No.21871013);the Drug Innovation Major Project(No.2018ZX09711-001-005-005)。
A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulati...
the National Natural Science Foundation of China (Nos.91849129,21807112);PLA Youth Medical Science and Technology Youth Development Program (No.16QNP086);Foundation of Second Military Medical University (No.2016JS11)
TNFR1-associated death domain protein(TRADD)with arginine N-GlcNAcylation is a novel and structurally unique posttranslational modification(PTM)glycoprotein that blocks the formation of death-inducing signaling comple...
supported by the National Natural Science Foundation of China (Nos. 21772008, 21632002 and U1606403);Natural Science Foundation of Guangdong Province (No. 2016A030306011);Shenzhen Basic Research Program (Nos. JCYJ20170818090044432 and JCYJ20160226105337556);Qingdao National Laboratory for Marine Science and Technology (No. LMDBKF201703)
In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiou...
the National Natural Science Foundation of China (Nos. 21322205, 21321061);the Ministry of Education of China (No. 20130181110022)
An alternative total synthesis of bolivianine in twelve steps is herein reported on the basis of our previous successful bioinspired total synthesis. The present total synthesis features straightforward transformation...
financial support from the National Natural Science Foundation of China(Nos.21322205,21321061,J1103315);the Ministry of Education of China(No.20130181110022)
First total synthesis of norleucosceptroids F and G has been achieved through key steps of Michael-AIdol cascade, oxa-Michael cyclization-dehydration-deprotection cascade and cross metathesis (CM), this work develop...
supported by the National Natural Science Foundation of China (Nos. 21102025 and 81360470);Program for New Century Excellent Talents in University (No. NCET-120656)
First total synthesis of cajanolactone A and cajanonic acid A has been achieved through steps of anion–anion condensations,cyclization,Williams etherification,selective demethylation,1 3-sigmatropic rearrangement and...
financially supported by the National Natural Science Foundation (Nos. 21162021, 20962016);the Program for New Century Excellent Talents in University (No. NCET-090860)
A concise approach for the frst total synthesis of two naturally occurring flavanoids,()-malaysianone A(1)and()-tanariflavanones B(2),has been accomplished with total yields of 12.9%and 10.4%,respectively.The ...