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作品数：163被引量：415H指数：9
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QuaPra: Efficient transcript assembly and quantification using quadratic programming with Apriori algorithm被引量：1
《Science China(Life Sciences)》2019年第7期937-946,共10页Xiangjun Ji Weida Tong Baitang Ning Christopher E. Mason David P. Kreil Pawel P. Labaj Geng Chen Tieliu Shi 
supported by the National High Technology Research and Development Program of China(2015AA020108);the National Key Research and Development Program of China(2016YFC0902100);the China Human Proteome Project(2014DFB30010,2014DFB30030);the National Science Foundation of China(31671377,31401133,31771460,91629103);the Program of Introducing Talents of Discipline to Universities of China(B14019)
RNA sequencing(RNA-seq) has greatly facilitated the exploring of transcriptome landscape for diverse organisms.However,transcriptome reconstruction is still challenging due to various limitations of current tools and ...
关键词：RNA-SEQ TRANSCRIPTOME RECONSTRUCTION TRANSCRIPT ASSEMBLY TRANSCRIPT quantification 
Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
《Science China(Life Sciences)》2019年第4期526-534,共9页Vandeclécio Lira da Silva André Mauricio Ribeiro dos Santos Wilfredo Blanco Sandro José de Souza 
supported by the Ludwig Institute for Cancer Research;CAPES(23038.004629/2014-19)
The gain of transcription factor binding sites(TFBS) is believed to represent one of the major causes of biological innovation.Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to ...
关键词：TFBS TRANSCRIPT factor human evolution EXPRESSION BREADTH 
Post-transcriptional gene silencing in plants： a double-edged sword被引量：4
《Science China(Life Sciences)》2016年第3期271-276,共6页Xinyan Zhang Ying Zhu Huihui Wu Hongwei Guo 
supported by the National Basic Research Program of China(2012CB910902);the National Natural Science Foundation of China(91217305;91017010)to H.G
In plants, post-transcriptional gene silencing(PTGS) protects the genome from foreign genes and restricts the expression of certain endogenous genes for proper development. Here, we review the recent progress about ho...
关键词：post-transcriptional gene silencing short interference RNA coding-transcript-derived siRNA RNA decay 
What we have learned from transcript profile analyses of male and female gametes in flowering plants被引量：1
《Science China(Life Sciences)》2010年第8期927-933,共7页XIN HaiPing & SUN MengXiang Key Laboratory of the Ministry of Education for Plant Developmental Biology, College of Life Science, Wuhan University, Wuhan 430072, China 
supported by the National Basic Research Program of China (Grant No. 2007CB108700);the National Natural Science Foundation of China (Grant Nos. 30821064 and 30771131)
Double fertilization is one of the predominant features of sexual reproduction in flowering plants but, because of the physical inaccessibility of gametes, the essential molecular mechanisms in these processes are lar...
关键词：SPERM CELL egg CELL fertilization cDNA library GAMETOGENESIS TRANSCRIPT PROFILE 
The enhancement effect of pp38 gene product on the activity of its upstream bi-directional promoter in Marek's disease virus被引量：2
《Science China(Life Sciences)》2006年第1期53-62,共10页REDDY Sanjay 
supported by the National Natural Science Foundation of China(Grant Nos.30300450&30070544).
There was a bi-directional promoter between gene 38 kd phosphorylated protein (pp38) gene; 1.8-kb mRNA transcript gene family in the genome of Marek's disease virus (MDV). In this study, enhanced green fluorescence pr...
关键词：Marek's disease virus (MDV)  pp38 gene  1.8-kb mRNA transcript  bi-directional promoter  trans-acting factor. 
A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2被引量：2
《Science China(Life Sciences)》2001年第6期561-569,共9页朱天慧 秦刚 Brigitte Roye r-Pokora 
the National Natural Science Foundation of China (Grant No. 39680024) and Tianjin Natural Science Foundation (Grant No. 993606011).
Lmo2 is a T cell leukemia-related proto-oncogene, which belongs to the LIM protein family. Previous work has established its key role in yolk sac erythropoiesis and adult hematopoiesis, and it is also necessary for re...
关键词：Lmo2 TRANSCRIPT splicing form promoter activity RT-PCR. 
Activity identification of chimeric anti-caspase-3 mRNA hammerhead ribozyme in vitro and in vivo被引量：1
《Science China(Life Sciences)》2001年第6期618-627,共10页徐人欢 刘静 徐丰 江舸 谢青 周霞秋 金由辛 王德宝 
the High School Science Foundation of Shanghai (Grant No. 98QN60) and the Chinese Academy of Sciences (Grant No. KSCX2-2-04).
To study the expression activity of various vectors containing anti-caspase-3 ribozyme cassettes in vivo, and to further study the role of caspas-3 in the apoptotic pathway, we constructed anti-caspase-3 hammerhead ri...
关键词：RIBOZYME CASPASE-3 TRANSCRIPT cleavage reaction BRL-3A cell. 
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