TRANSCRIPTION_FACTORS

作品数：329被引量：1841H指数：21
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Genetic analysis of transcription factors in dopaminergic neuronal development in Parkinson’s disease
《Chinese Medical Journal》2024年第4期450-456,共7页Yuwen Zhao Lixia Qin Hongxu Pan Tingwei Song Yige Wang Xiaoxia Zhou Yaqin Xiang Jinchen Li Zhenhua Liu Qiying Sun Jifeng Guo Xinxiang Yan Beisha Tang Qian Xu 
supported by grants from the National Natural Science Foundation of China(Nos.82071437,U20A20355,and 82101342);the Hunan Innovative Province Construction Project(No.2019SK2335);the Natural Science Foundations of Hunan Province(No.2021JJ31115);the National Key Research and Development Program of China(Nos.2016YFC1306000 and 2021YFC2502100);the Project Program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)(No.2021KFJJ10)
Background:Genetic variants of dopaminergic transcription factor-encoding genes are suggested to be Parkinson’s disease(PD)risk factors;however,no comprehensive analyses of these genes in patients with PD have been u...
关键词：Parkinson’s disease Transcription factors Dopaminergic neurons GENETIC VARIANTS 
Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation被引量：2
《Chinese Medical Journal》2024年第2期130-139,共10页Hanfei Guo Wenqian Li Ye Guo Naifei Chen Jiuwei Cui 
supported by grants from the Jilin Scientific and Technological Development Program(CN)(No.20190303146SF);General Program of National Natural Science Foundation of China(No.81874052)
Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the disease.In recent years,emerging molecular cla...
关键词：Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors GENOMICS PHENOTYPE PROGNOSIS 
Transcription factors T-bet/GATA-3/Foxp3 in peripheral blood of patients with chronic otitis media with effusion被引量：2
《Chinese Medical Journal》2019年第13期1629-1631,共3页Lin Yang Shou-Qin Zhao Ying Li Ran Ren Chen-Yi Wei Jin-Song Yang Bin-Bin Yang 
a grant from the National Natural Science Foundation of China(No.81770989).
To the Editor:Otitis media with effusion(OME),also known as secretory otitis,is a disease in which secreted fluid accumulates in the middle ear cavity and is a major cause of hearing loss,both in children and adults.[...
关键词：TRANSCRIPTION factors chronic OTITIS media EFFUSION 
Three transcription factors and the way immune cells affected by different plasma change in opposite ways in the development of the syndrome of pre-eclampsia被引量：4
《Chinese Medical Journal》2014年第12期2252-2258,共7页Liang Zhou Zhu Jing Wang Yunfei Wang You Zhang Yu Lin Jianhua Di Wen 
Background How the transcriptional factors regulated the innate and adaptive immune system in pregnancy and preeclampsia are less understood.Nevertheless,what the plasma work in the development of this disease was not...
关键词：PRE-ECLAMPSIA MONOCYTES T cells transcription factors 
Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB被引量：10
《Chinese Medical Journal》2010年第17期2440-2445,共6页SONG Hong-shuo SHI Shuang LU Xiao-zhi GAO Feng YAN Ling WANG Ying ZHUANG Hui 
Background The CKLF-like MARVEL transmembrane domain-containing family （CMTM） is a novel family of proteins linking chemokines and TM4SF. Different members exhibit diverse biological functions. In this study, the ef...
关键词：CMTM2 HIV-1 long terminal repeat regulation 
Nuclear transcription factors and lipid homeostasis in liver被引量：8
《Chinese Medical Journal》2007年第24期2290-2296,共7页CHEN Ya-xi HUANG Ai-long RUAN Xiong-zhong Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China(Chen YX,Huang AL and Ruan XZ) 
This study was supported by the grants from the National Natural Science Foundation of China(Key Program,No.30530360);the National Basic Research Program of China(No.2006CB503907)
The liver plays a major role in the regulation , glucose, lipid and energy metabolism. Increasd hepatic fat deposit is a very common feature in obese, insulin-resistant patients, in metabolic syndrome, alcoholic steat...
关键词：nuclear transcription factors lipid homeostasis fatty liver 
Treatment of allergic airway inflammation and hyperrespon-siveness by imiquimod modulating transcription factors T-bet and GATA-3被引量：15
《Chinese Medical Journal》2006年第8期640-648,共9页BIAN Tao YIN Kai-sheng JIN Shu-xian ZHANG Xi-long ZHOU Jin-yong MA Xiu-qin HU Jing-jing DE Wei 
Background Imiquimod is an imidazoquinoline, which class of compounds are known to have antiviral and antitumoural properties. In recent studies, it was shown that imiquimod modulates the T helper cell type Th1/Th2 re...
关键词：ASTHMA T-BET GATA-3 IMIQUIMOD 
Decline in the expression of IL-2 after trauma and changes in the nuclear transcription factors NFAT and AP-1被引量：1
《Chinese Medical Journal》2002年第9期1348-1351,150,共4页罗艳 梁华平 胡承香 徐祥 王正国 
ThisworkwassupportedbytheNationalBasic"973ResearchProgramofChina (G19990 5 42 0 3)andthegrantfromtheNationalNaturalScienceFoundationofChina (No 3 9870 82 8)
OBJECTIVE: To investigate whether the decrease in expression of interleukin-2 (IL-2) after trauma is associated with changes in DNA binding activity of nuclear factor of activated T cells (NFAT) and activator protein-...
关键词：Nuclear Proteins Animals Cell Nucleus DNA DNA-Binding Proteins Electrophoretic Mobility Shift Assay Female INTERLEUKIN-2 Male Mice NFATC Transcription Factors Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun RNA  Messenger Research Support  Non-U.S. Gov't Transcription Factor AP-1 Transcription Factors 
Review of current progress in the structure and function of Smad proteins被引量：49
《Chinese Medical Journal》2002年第3期446-450,共5页陈伟 付小兵 盛志勇 
supported by a grant from the National Natural Science Foundation of China(No．G1999054204)； the National Prominent Youth Science Foundation of China(No．39525024)．
PURPOSE: To review the recent developments in the structure and function of Smad proteins. DATA SOURCES: Both Chinese- and English-language literatures were searched using MEDLINE/CD-ROM (1997 - 2000) and the Index of...
关键词：DNA-Binding Proteins Humans Research Support  Non-U.S. Gov't Signal Transduction Smad Proteins TRANS-ACTIVATORS Transcription Factors Transforming Growth Factor beta 
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