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Prognostic significance and multidimensional roles of interferon regulatory factors in cancer biology:A comprehensive analysis
《Genes & Diseases》2025年第3期15-18,共4页Guo Ji Shuyuan Xian Jiaqi Song Shiyu Mao Man Pi Qiongyi Huang Xue Han Jian Yin Zan Wu Runzhi Huang Dongyan Han Zhengyan Chang 
supported in part by the National Natural Science Foundation of China(No.82002923,82203505).
Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell develop...
关键词：interferon regulatory factors irfs interferon regulatory factors multidimensional correlation analysiswe multidimensional roles STEMNESS transcription factors immune subtype cancer biology 
Transcription factors,metabolic dysfunction-associated fatty liver disease,and therapeutic implications
《Genes & Diseases》2025年第3期137-145,共9页Shuwei Hu Yingjie Ai Chencheng Hu Fathima N.Cassim Bawa Yanyong Xu 
supported by the National Natural Science Foundation of China(No.32271218 to Y.X.).
Metabolic dysfunction-associated fatty liver disease(MAFLD)encompasses a spectrum of liver diseases ranging from metabolic dysfunction-associated fatty liver to metabolic dysfunction-associated steatohepatitis,which m...
关键词：Apoptosis FIBROSIS Inflammation MAFLD STEATOSIS Transcription factors 
Understanding the Molecular Mechanisms of Nitrogen Assimilation in C3 Plants under Abiotic Stress: AMini Review
《Phyton-International Journal of Experimental Botany》2025年第4期1029-1045,共17页Saif Ullah Izhar Ali 
Nitrogen(N)assimilation is crucial for the growth and development of C3 plants,as it converts inorganic N into organic forms,important for protein synthesis,nucleic acids and other vital biomolecules.However,abiotic s...
关键词：C3 plants abiotic stress nitrogen metabolism transcription factors 
Transcriptional activation of MdDEF30 by MdWRKY75 enhances apple resistance to Cytospora canker
《Journal of Integrative Agriculture》2025年第3期1108-1125,共18页Hongchen Jia Youwei Du Yuanyuan Liu Shuanghong Wang Yan Wang Sadia Noorin Mark LGleason Rong Zhang Guangyu Sun 
funded by the National Key R&D Program of China(2023YFD1401401);the China Agriculture Research System(CARS27)。
Defensin,an essential component of plant development,is indispensable in pathogen resistance.However,the molecular function of defensins under pathological conditions of Cytospora canker has not been characterized in ...
关键词：apple calli DEFENSIN gene family Cytospora mali induced resistance antifungal activity weighted correlation network analysis(WGCNA) transcription factors 
Time-course transcriptomic analysis reveals transcription factors involved in modulating nitrogen sensibility in maize
《Journal of Genetics and Genomics》2025年第3期400-410,共11页Mingliang Zhang Yuancong Wang Qi Wu Yangming Sun Chenxu Zhao Min Ge Ling Zhou Tifu Zhang Wei Zhang Yiliang Qian Long Ruan Han Zhao 
supported by the National Natural Science Foundation of China(32272133);the“JBGS”Project of Seed Industry Revitalization in Jiangsu Province(JBGS(2021)012);Jiangsu Agriculture Science and Technology Innovation Fund(CX(21)1003);Anhui Provincial Major Science and Technology Project(202003a06020004);Jiangsu Funding Program for Excellent Postdoctoral Talent(JB23058,2023ZB422).
Nitrogen(N)serves both as a vital macronutrient and a signaling molecule for plants.Unveiling key regulators involved in N metabolism helps dissect the mechanisms underlying N metabolism,which is essential for develop...
关键词：MAIZE GENOTYPE N response DiffCoEx network MADS26 
Identification of transcription factors contributing to vitamin C synthesis during Rosa roxburghii fruit development by integrating transcriptomics and metabolomics
《Horticultural Plant Journal》2025年第1期123-132,共10页Liyao Su Tian Zhang Zong-Ming(Max)Cheng 
supported in part by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the State Key Laboratory of Crop Genetics and Germplasm Enhancement (Grant No. ZW201813);supported by the high-performance computing platform at the Bioinformatics Center of Nanjing Agricultural University。
Ascorbic acid, also referred to as vitamin C(Vc), is an important nutrient found in fruits and vegetables that promotes produce quality and human health. Rosa roxburghii is an underutilized natural fruit that contains...
关键词：Rosa roxburghii Vitamin C WGCNA TRANSCRIPTOME METABOLOME 
Zinc finger transcription factors BnaSTOP2s regulate sulfur metabolism and confer Sclerotinia sclerotiorum resistance in Brassica napus
《Journal of Integrative Plant Biology》2025年第1期101-116,共16页Lihong Dai Zhaoqi Xie Tianxu Ai Yushun Jiao Xiaoyi Lian Angchen Long Jinyun Zhang Guangsheng Yang Dengfeng Hong 
supported by the National Key Research and Development Program of China(2022YFD1200400);the Program for Modern Agricultural Industrial Technology System(CARS-12)。
Rapeseed(Brassica napus L.)exhibits high-sulfur requirements to achieve optimal growth,development,and pathogen resistance.Despite the importance of sulfur,the mechanisms regulating its metabolism and disease resistan...
关键词：BnaSTOP2 Brassica napus CRISPR/Cas9 GLUCOSINOLATE Sclerotinia sclerotiorum sulfur metabolism 
An enhancer–promoter-transcription factor module orchestrates plant immune homeostasis by constraining camalexin biosynthesis
《Molecular Plant》2025年第1期95-113,共19页Ying Zhang Meng Tang Yi Zhang Qinglin Cheng Lijiang Liu Wei Chen Jiatao Xie Jiasen Cheng Yanping Fu Bo Li Daohong Jiang Xiao Yu 
This research was supported by the National Natural Science Foundation of China(grant no.32200242 to X.Y.);funds from the National Key Laboratory of Agricultural Microbiology(grant no.AML2023B07 to X.Y.);the National Natural Science Foundation of China(grant no.32130087 to D.J.);the Earmarked Fund for CARS-12(to D.J.);Fundamental Research Funds for the Central Universities(grant no.2662023PY006 and2662023ZKPY001toB.L).
Effective plant defense against pathogens relies on highly coordinated regulation of immune gene expression.Enhancers,as cis-regulatory elements,are indispensable determinants of dynamic gene regulation,but the molecu...
关键词：plant innate immunity ENHANCERS antifungal resistance transcriptional regulation cis-regulatory elements transcription factors 
Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny
《Cell Regeneration》2024年第1期287-304,共18页Yazhou Cuiand Guangjin Pan Fei Li Yanling Zhu Tianyu Wang Jun Tang Yuhua Huang Jiaming Gu Yuchan Mai Mingquan Wang Zhishuai Zhang Jiaying Ning Baoqiang Kang Junwei Wang Tiancheng Zhou Yazhou Cui Guangjin Pan 
National Key Research and Development Program of China,Stem Cell and Translational Research(2022YFA1105001);Research Funds from Health@InnoHK Program launched by Innovation Technology Commission of the Hong Kong SAR,P.R.China;National Natural Science Foundation of China(31971374,32171451);Science and Technology Planning Project of Guangdong Province,China(2023B1212060050,2023B1212120009);Youth Innovation Promotion Association of the Chinese Academy of Sciences(to Y.Z.2023373);China Postdoctoral Science Foundation Funded Project(2023M733516);Fountain-Valley Life Sciences Fund of University of Chinese Academy of Sciences Education Foundation(ZXXM202201);Guangzhou Key Research and Development Program(202206010041);Guangzhou Science and Technology Program General project(2024A04J3801);Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine(2020B1212060052);Guangdong Province Special Program for Outstanding Talents(to G.P.,2019JC05Y463).
Human hematopoiesis starts at early yolk sac and undergoes site-and stage-specific changes over development.The intrinsic mechanism underlying property changes in hematopoiesis ontogeny remains poorly understood.Here,...
关键词：Hematopoietic stem cell Transcription factors Lineage potential Gene regulatory networks Human induced pluripotent stem cells Hematopoietic differentiation 
JAZ proteins:Key regulators of plant growth and stress response
《The Crop Journal》2024年第6期1505-1516,共12页Xiaoqian Zhao Yongqi He Yuxin Liu Zhoufei Wang Jia Zhao 
funded by the National Natural Science Foundation of China (32372156,32201838,32272157);the Natural Science Foundation of Guangdong Province (2024A1515011084,2023A1515012052,2023A1515012092);the Science and Technology Project of Guangzhou (2023A04J0749,2023A04J1452).
The jasmonate ZIM-domain(JAZ)family of proteins serves as co-receptors and transcriptional repressors of jasmonic acid(JA)in plants.Their functional diversity and multiple roles make them important components of the r...
关键词：Jasmonate ZIM-domain proteins Transcription factors Plant growth Stress tolerance 
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