TRANSDUCTION

作品数:235被引量:650H指数:13
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Computational prediction and functional analysis of arsenic-binding proteins in human cells
《Quantitative Biology》2019年第3期182-189,共8页Shichao Pang Junchen Yang Yilei Zhao Yixue Li Jingfang Wang 
This work was supported by the National Key R&D Program of China(Nos.2016YFC0901704 and 2017YFA0505500);National High-Tech R&D Program(863 Program,No.2015AA020105);the National Natural Science Foundation of China(Nos.21377085 and 31770070);MOE New Century Excellent Talents in University(No.NCET-12-0354);SJTU Med-Eng Joint Program(No.YG2016MS33)for financial supports.
Background:Arsenic has a broad anti-cancer ability against hematologic malignancies and solid tumors.To systematically understand the biological functions of arsenic,we need to identify arsenic-binding proteins in hum...
关键词:arsenic-binding proteins free energy profile position-specific SCORE matrix signaling TRANSDUCTION 
Cell type specificity of signaling:view from membrane receptors distribution and their downstream transduction networks
《Protein & Cell》2012年第9期701-713,共13页Ying He Zhonghao Yu Dongya Ge Rui Wang-Sattler Hans-Jurgen Thiesen Lu Xie Yixue Li 
kindly funded by National Natural Science Foundation of China(Grant No.31070752);in part supported by the National Basic Research Program(973 Program)(Nos 2011CB910204,2010CB529206 and 2010CB912702);Key Infectious Disease Project(No.2012ZX10002012-014);Research Program of Chinese Academy of Sciences(Nos.KSCX2-EW-R-04,KSCX2-YW-R-190 and 2011KIP204);National Natural Science Foundation of China(Grant No.30900272);Chinese Ministry for Science and Technology Grant(No.2008BAI64B01);the National High Technology Research and Development Program(863 Program)(No.2009AA02Z304).
Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular capabilities.To overview the specificity of cell signaling,we integrated human re...
关键词:plasma membrane receptor cellular signaling transduction network diversity cell type specific spatial expression profile 
Model Transduction for Triangle Meshes
《Journal of Computer Science & Technology》2010年第3期583-594,共12页吴怀宇 潘春洪 查红彬 马颂德 
supported by the National Natural Science Foundation of China under Grant Nos. 60903060 and 60675012;the National High-Tech Research and Development 863 Program of China under Grant No. 2009AA012104;the China Postdoctoral Science Foundation under Grant No. 20080440258
This paper proposes a novel method, called model transduction, to directly transfer pose between different meshes, without the need of building the skeleton configurations for meshes. Different from previous retargett...
关键词:retargetting mesh deformation mean-value manifold operator cross-parameterization model transduction 
The endocrine regulation network of growth hormone synthesis and secretion in fish: Emphasis on the signal integration in somatotropes被引量:12
《Science China(Life Sciences)》2010年第4期462-470,共9页LI WenSheng & LIN HaoRan State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and the Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China 
supported by the National Basic Research Program of China (Grant No. 2010CB126302);the Earmarked Fund for Modern Agro-industry Technology Research System for Tilapia;the Agriculture Research Special Funds of 3-49;the National High Technology Research and Development Program of China (Grant No. 2007AA091404) to Dr. Li WenSheng
In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pitu...
关键词:FISH growth HORMONE RECEPTOR signal TRANSDUCTION 
Regulation of apoptotic signal transduction pathways by the heat shock proteins被引量:8
《Science China(Life Sciences)》2004年第2期107-114,共8页LI Zhengyu1, ZHAO Xia1 & WEI Yuquan2 1. Department of Gynecology and Obstetrics, West China Second Hospital of Sichuan University, Chengdu 610041, China 2. Key Laboratory of Biotherapy of Human Diseases of Ministry of Education, West China Hospital of Sichuan university, Chengdu 610041, China 
supported by the National Natural Science Foundation of China(Grant Nos.30070835&30070294);National 863 Project.
The study about apoptotic signal transductions has become a project to reveal the molecular mechanisms of apoptosis. Heat shock proteins (hsps), which play an important role in cell growth and apoptosis, have attracte...
关键词:heat shock protein  APOPTOTIC signal transduction  MOLECULAR chaperone  caspases. 
Effects of simulated microgravity on nitric oxide level in cardiac myocytes and its mechanism被引量:7
《Science China(Life Sciences)》2003年第3期302-309,共8页熊江辉 李莹辉 聂捷琳 
supported by National Plan of High-Tech Research and Development(863-2-2-2-4).
The depression of cardiac contractility induced by space microgravity is an important issue of aerospace medicine research, while its precise mechanism is still unknown. In the present study, we explored effects of si...
关键词:simulated microgravity  cardiac myocytes  NITRIC oxide  NITRIC OXIDE synthase  protein kinase C  signal transduction. 
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