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作品数：235被引量：650H指数：13
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相关机构：首都医科大学中国科学院上海生命科学研究院四川大学中国农业大学更多>>
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Atorvastatin induces autophagy of mesenchymal stem cells underhypoxia and serum deprivation conditions by activating the mitogen-activated protein kinase/extracellular signal-regulatedkinase pathway被引量：7
《Chinese Medical Journal》2014年第6期1046-1051,共6页
This work was supported by grants from the National Natural Science Foundation of China （No. 81170129 and No. 81000091）, the China Health Medical Development Foundation （No. 2011-H25）, the Research Fund of Capital Medical Development （No. 2007-2018）, 863 Program of China （No. 2011AA020110）, and the Postgraduates＇ Innovative Research Foundation of Peking Union Medical College （2012-1002-31）.
Background The survival ratio of implanted mesenchymal stem cells （MSCs） in the infarcted myocardium is low.Autophagy is a complex self-eating process and can be utilized for cell survival. We have found that atorva...
关键词：mesenchymal STROMAL cells myocardial infarction AUTOPHAGY hydroxymethylglutaryl-CoA REDUCTASE inhibitors signal TRANSDUCTION 
Transduction of mesenchymal stem cells with multidrug resistance gene provides protection for bone marrow toxicity after being transplanted into a nude mice model被引量：1
《Chinese Medical Journal》2012年第18期3246-3250,共5页HAN Li-ying LIYa-ping YE Ming-zhu WANG Bo-wei WANG Qiang ZHAO Shu-hua LI He-lian 
This study was supported by a grant from the National Natural Science Foundation of China
Background Myelosuppression is the main dose-related toxicity of many chemotherapeutic drugs. The human multidrug resistance （mdrl） gene is well-known for its ability to confering drug resistance. In this study, we ...
关键词：stem cells transfer  drug resistance  nude mouse  chemotherapy 
Adenoviral transduction of PTEN induces apoptosis of cultured hepatic steUate cells被引量：3
《Chinese Medical Journal》2009年第23期2907-2911,共5页HAO Li-sen ZHANG Xiao-lan AN Jun-yan YAO Dong-mei Justin Karlin FANG Shu-ming JIANG Hui-qing BAI Wen-yuan CHEN Shuang 
This study was supported by a grant from the National Natural Science Foundation of China （No. 30872513）.
Hepatic fibrosis is the liver＇s wound healing response to virtually all forms of chronic liver injury： toxic insult, viral infection, immunological conditions and metabolic diseases. Uncontrolled liver fibrosis even...
关键词：PTEN protein hepatic stellate cells FIBROSIS APOPTOSIS 
Upregulation of drug sensitivity of multidrug resistant SGC7901/VCR human gastric cancer cells by bax gene transduction被引量：10
《Chinese Medical Journal》2000年第11期17-20,共4页赵燕秋 肖冰 陈宝军 乔泰东 樊代明 
To investigate the role of bax in a vincristine (VCR) induced multidrug resistant (MDR) human gastric cancer cell line, SGC7901/VCR, in which the Bax protein expression level was significantly lower compared with th...
关键词：bax  · gastric cancer  · multidrug resistance  · gene transduction  · apoptoH 
Some changes of receptor and postreceptor signal transduction regulated by somatostatin in pituitary hGH-secreting adenomas
《Chinese Medical Journal》1997年第9期22-25,共4页邓洁英 史轶蘩 尹娟娟 
Objective To investigate the disturbance in the function of SRIF receptor, Gi protein and Ca 2+ channel in hGH adenoma cells and to evaluate their significance in the pathogenesis of pituitary hGH adenomas. Met...
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