VARIANTS

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A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity
《Cell Research》2023年第12期975-978,共4页Yunping Ma Qiyu Mao Yingdan Wang Zhaoyong Zhang Jiali Chen Aihua Hao Palizhati Rehati Yanqun Wang Yumei Wen Lu Lu Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang 
supported by the National Natural Science Foundation of China(32370995 and 31771008 to J.H.and 3197014 to Z.C.);the Shanghai Municipal Science and Technology Major Project(ZD2021CY001 to J.H.);the Ministry of Science and Technology of China(2021YFC2302500 to L.S.);the National Youth Talent Support Program(2022 to F.W.);the“Shuguang Program”of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(22SG16 to F.W.);Guangzhou Laboratory(SRPG22-003 to L.S.);the National Science and Technology Major Projects of China(2017ZX10202102 to J.H.and 2018ZX10301403 to F.W.).
Dear Editor,Since the start of the COVID-19 pandemic,thousands of neutralizing antibodies(NAbs)targeting different epitopes of the spike protein have been identifed and characterized.1-3 However,the emergence of the O...
关键词：NEUTRAL sized HARBOR 
Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection被引量：3
《Cell Research》2023年第3期258-261,共4页Bo Gao Liheng He Yujie Bao Yingying Chen Guanzhu Lu Yu Zhang Yingjie Xu Bing Su Jie Xu Ying Wang Leng-Siew Yeap 
This work was supported by funds from the National Key R&D Program of China(2021YFA1301400 to B.S.,Y.X.,L.-S.Y.,and 2021YFC2301500 to Y.W.);the National Natural Science Foundation of China(31722020 to L.-S.Y.,31930035,91942311 and 32061143028 to B.S.);Shanghai Science and Technology Commission(20410714000,20JC410100 and 22JC1402600 to B.S.).
Dear Editor,Since the emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019,the virus has continued to evolve resulting in new waves of infection and immune escape in the vaccinated populatio...
关键词：VACCINATION ANTIBODIES INFECTION 
Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron被引量：2
《Cell Research》2022年第9期831-842,共12页Huan Ma Xinghai Zhang Peiyi Zheng Peter H.Dube Weihong Zeng Shaohong Chen Qingyu Cheng Yunru Yang Yan Wu Junhui Zhou Xiaowen Hu Yan Xiang Huajun Zhang Sandra Chiu Tengchuan Jin 
SARS-CoV-2 variants with adaptive mutations have continued to emerge,causing fresh waves of infection even amongst vaccinated population.The development of broad-spectrum antivirals is thus urgently needed.We previous...
关键词：prevention spectrum continued 
Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants,including Omicron sublineages被引量：1
《Cell Research》2022年第7期691-694,共4页Lei Wang Wangjun Fu Linlin Bao Zijing Jia Yuxia Zhang Yunjiao Zhou Wei Wu Jianbo wu Qianqian Zhang Yidan Gao Kang Wang Qiao Wang Chuan Qin Xiangxi Wang 
supported by Ministry of Science and Technology of China(CPNL2022A-03-03,CPNL-1233,EKPG21-09),CAS(YSBR-010),the Strategic Priority Research Program(XDB29010000,XDB37030000);the National Key R&D Program(2020YFA0707500,2018YFA0900801,2021YFA1301400);the National Natural Science Foundation of China(31872730,32070947);Beijing Municipal Science and Technology Project(Z201100005420017);supported by Ten Thousand Talent Program and the NSFS Innovative Research Group(81921005).
Dear Editor,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to the lineage B of the genus Betacoronavirus in the Coronaviridae family,is the causative agent of the C0VID19 pandemic,1 which ha...
关键词：HAS BASES NEUTRAL 
Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo被引量：1
《Cell Research》2022年第6期589-592,共4页Mengjiao Li Zi-Wei Ye Kaiming Tang Liang Guo Wenwen Bi Yuyuan Zhang Yan-dong Tang Guoguang Rong Mohamad Sawan Xin Yin Ren Sun Shuofeng Yuan Bobo Dang 
supported by the Westlake Education Foundation and Tencent Foundation,the Key R&D Program of Zhejiang Province(2021C03040);the National Natural Science Foundation of China(22077104,32120103013);supported by funding to The University of Hong Kong:the Health and Medical Research Fund(COVID1903010-Project 15 and 20190732,20190692);the Food and Health Bureau,the Government of the Hong Kong Special Administrative Region;the Theme-Based Research Scheme of the Research Grants Council(T11-709/21-N).
Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has resulted in a severe global pandemic that has lasted for more than two years.1 Several vaccines were developed at an unprecedented speed to protect bil...
关键词：ACE2 VACCINE immunity 
Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern被引量：25
《Cell Research》2022年第1期103-106,共4页Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang 
supported by the National Natural Science Foundation of China(82041010);the Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response(20dz2260100);the Key Discipline Construction Plan from Shanghai Municipal Health Commission(GWV-10.1-XK01).
Dear Editor,As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decre...
关键词：RBD protective neutral 
Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants被引量：2
《Cell Research》2021年第10期1126-1129,共4页Hua Xu Bo Wang Tian-Ning Zhao Zi-Teng Liang Tian-Bo Peng Xiao-Hui Song Jia-Jing Wu You-Chun Wang Xiao-Dong Su 
We thank the National Center for Protein Sciences at Peking University in Beijing,China,for assistance with SPR assay.We thank the staff of the Shanghai Synchrotron Radiation Facility(beamline BL17U)and the National Facility for Protein Science Shanghai(beamline BL19U)for assistance with X-ray data collection.We thank the KEK Photon Factory(beamline BL1A)and staff members for their assistance in X-ray data collection.We thank the Core Facilities at the School of Life Sciences,Peking University,for help with negative-staining EM.This project was supported by the Ministry of Science and Technology of China(2020YFC0848700)and the Qidong-SLS Innovation Fund to X.-D.S.This project was also supported by the Beijing Science and Technology Project(Z211100002521018);the National Natural Science Foundation of China(82073621,32070678);the National Key R&D Program of China(2021YFC0863300)to Y.-C.W.Special thanks to Drs.Sunney Xie,Junyu Xiao,Yunlong Cao for providing plasmids and IgG samples of the antibodies.
Dear Editor,SARS-CoV-2 variants are developing rapidly among COVID-19 patients,likely resulting in higher transmissibility at the population level.^(1,2,3,4,5) Mutations in the spike proteins(S proteins)of these varia...
关键词：invasion alterations RBD 
Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants被引量：4
《Cell Research》2021年第10期1130-1133,共4页Shuo Du Pulan Liu Zhiying Zhang Tianhe Xiao Ayijiang Yasimayi Weijin Huang Youchun Wang Yunlong Cao Xiaoliang Sunney Xie Junyu Xiao 
We thank the Core Facilities at the School of Life Sciences, Peking University for help with negative-staining EM;the Cryo-EM Platform of Peking University for help with data collection;the High-performance Computing Platform of Peking University for help with computation. We also thank Shuimu BioSciences Ltd. and Chuan Liu for the help with some data collection and processing. The work was supported by the National Key R&D Program of China (2020YFC0848700, 2017YFA0505200);the National Natural Science Foundation of China (31822014), and the Qidong-SLS Innovation Fund.
Dear Editor,The spread of the SARS-CoV-2 variants,especially the global variants of concern(VOCs),could seriously dampen our efforts to tackle the COVID-19 pandemic.The SARS-CoV-2 spike protein recognizes the host ang...
关键词：ACE2 concerning NEUTRAL 
Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines被引量：21
《Cell Research》2021年第7期732-741,共10页Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie 
supported by Beijing Advanced Innovation Center for Genomics at Peking University and the Ministry of Science and Technology of China(2020YFC0848700).
SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B...
关键词：vaccines doses markedly 
Author Correction:Threshold for neural tube defect risk by accumulated singleton loss-of-function variants
《Cell Research》2021年第4期488-488,共1页
Correction to:Cell Research https://doi.org/10.1038/s41422-018-0061-3,published online 05 July 2018 We apologize for missing Competing interests for the original article.ADDITIONAL INFORMATION Competing interests:R.H....
关键词：neural defect TRAVEL 
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