VARIANTS

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  • 期刊=Signal Transduction and Targeted Therapyx
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Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants
《Signal Transduction and Targeted Therapy》2024年第12期5752-5764,共13页Hong Lei Weiqi Hong Jingyun Yang Cai He Yanan Zhou Yu Zhang Aqu Alu Jie Shi Jian Liu Furong qin Danyi Ao Xiya Huang Zimin Chen Hao Yang Yun Yang Wenhai Yu Cong Tang Junbin Wang Bai Li Qing Huang Hongbo Hu Wei Cheng Haohao Dong Jian Lei Lu Chen Xikun Zhou Jiong Li Li Yang Zhenling Wang Wei Wang Guobo Shen Jinliang Yang Zhiwei Zhao Xiangrong Song Guangwen Lu Qiangming Sun Youchun Wang Shuaiyao Lu Xiawei Wei 
supported by the National Science Foundation for Excellent Young Scholars(32122052,X.W.);National Natural Science Foundation Regional Innovation and Development(No.U19A2003,X.W.);National Natural Science Foundation of China(32300743,H.L.);the Project of the Science and Technology Department of Sichuan Province(NO.2024NSFSC1757,H.L.);National Natural Science Foundation of China Young Student Basic Research Program(323B2050,W.H.)。
The mucosal immune response plays a crucial role in the prevention of respiratory viruses.Given the risk of recurrent SARS-CoV-2 infections in the population,the rapid development of next-generation intranasal COVID-1...
关键词：NASAL IMMUNITY protective 
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies被引量：2
《Signal Transduction and Targeted Therapy》2024年第6期2359-2361,共3页Xun Wang Shujun Jiang Wentai Ma Yanliang Zhang Pengfei Wang 
supported by funding from the National Natural Science Foundation of China(32270142 to P.W.);the Shanghai Rising-Star Program(22QA1408800 to P.W.);the Program of Science and Technology Cooperation with Hong Kong region,Macao region,and Taiwan region(23410760500 to P.W.);Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine(YBZX2022 to Y.Z.);NATCM’s Project of High-level Construction of Key TCM Disciplines;support from AI for Science project of Fudan University(XM06231724);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(No.SKLGE-2304);Xiaomi Young Talents Program.
Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of s...
关键词：evolve NEUTRALIZATION VARIANTS 
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2312-2323,共12页Xian Li Mengxin Xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen 
National Key R&D program of China(Grant number:2022YFC2304204 to Y.-Q.C.,2021YFC2302602 to J.Y.);National Natural Science Foundation of China(grant number:82341041 to H.Y.and 92169104 to Y.-Q.C.);Shanghai Science and Technology Innovation Action Plan(Grant number:22Y11901000 to Q.W.);Shenzhen Science and Technology Program(Grant number:RCJC20210706092009004,JCYJ2020010914243811,KQTD20200820145822023 to Y.-Q.C.)supported this work in whole or in part.
Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic.Here,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple rece...
关键词：VACCINATION VACCINE SUSTAINED 
Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge
《Signal Transduction and Targeted Therapy》2023年第10期4914-4926,共13页Qianyun Liu Haiyan Zhao Zhiqiang Li Zhen Zhang Rui Huang Mengxue Gu Ke Zhuang Qing Xiong Xianying Chen Weiyi Yu Shengnan Qian Yuzhen Zhang Xue Tan Muyi Zhang Feiyang Yu Ming Guo Zhixiang Huang Xin Wang Wenjie Xiang Bihao Wu Fanghua Mei Kun Cai Limin Zhou Li Zhou Ying Wu Huan Yan heng Cao Ke Lan Yu Chen 
This study was supported by the National Natural Science Foundation of China(32188101 to K.L.,32122008 to Y.W.,32270164 to H.Y.,and 32070160 to H.Y.);National Science and Technology Major Project(2022YFC2604100 to H.Z.and L.Z.,2021YFC2300702 to L.Z.,and 2021YFF0702004 to Y.C.);Fundamental Research Funds for the Central Universities(2042023kf0191 and 2042022kf1188 to H.Y.);Hubei Provincial Natural Science Foundation(2023AFA015 to H.Y.),China Postdoctoral Science Foundation(2023M732705 to Q.L.);Hubei Provincial Public Health Outstanding Young Talents Project(to K.C.).
Coronavirus disease 2019(COviD-19)was first reported three years ago,when a group of individuals were infected with the original SARS-CoV-2 strain,based on which vaccines were developed.Here,we develop six human monoc...
关键词：antibodies MONOCLONAL neutral 
Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants
《Signal Transduction and Targeted Therapy》2023年第8期3567-3569,共3页Aihua Hao Wenping Song Cheng Li Xiang Zhang Chao Tu Xun Wang Pengfei Wang Yanling Wu Tianlei Ying Lei Sun 
This work was supported by grants from the Ministry of Science and Technology of China(2019YFA0904400 to TY,2021YFC2302500 to LS);National Natural Science Foundation of China(32270984,32270142);Shanghai Municipal Science and Technology Major Project(ZD2021CY001);by R&D Program of Guangzhou Laboratory(SRPG22-003 to LS).
Dear Editor,In recent months,additional Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),including the BA.5 sublineage BF.7 and BQ.1.1 and the BA.2 linage recombination XBB,XBB.1.5 and X...
关键词：ACUTE VARIANTS CONSERVED 
Correction To:Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARSCoV-2 variants被引量：4
《Signal Transduction and Targeted Therapy》2023年第6期3184-3184,共1页Qian Wang Chenchen Yang Li Yin Jing Sun Wei Wang Hengchun Li Zhengyuan Zhang Si Chen Bo Liu Zijian Liu Linjing Shi Xiaolin Liu Suhua Guan Chunhua Wang Linbing Qu Ying Feng Xuefeng Niu Liqiang Feng Jincun Zhao Pingchao Li Ling Chen Nanshan Zhong 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-023-01423-6,published online 17 April 2023 After online publication of the article^(1),the authors noticed two inadvertent mistakes...
关键词：IMMUNITY MISTAKE noticed 
Evolutionary characteristics of SARS-CoV-2 Omicron subvariants adapted to the host
《Signal Transduction and Targeted Therapy》2023年第6期2478-2480,共3页Haijun Tang Yun Shao Yi Huang Shigang Qiao Jianzhong An Ruhong Yan Xin Zhao Fang Meng Xiaohong Du F.Xiao-Feng Qin 
The National Natural Science Foundation of China(Grant 31800726,81773058);CAMS Innovation Fund for Medical Sciences(2022-12M-2-004,2016-12M-1-005);National Grand Foreign Experts Projects(G20190001633,G20190001639,G2021016012L);Zhejiang Provincial Science and Technology Department(Grant 2021C03198);Jinhua Municipal Science and Technology Department(Grant2021-3-033).
Dear Editor,As the COVID-19 epidemic proceeds,new variants of SARS-CoV-2 continue to emerge.^(1)Particularly the B.1.1.529(Omicron)variant emerged and spread globally,surpassing the previously dominant B.1.617.2(Delta...
关键词：adapted VARIANTS globally 
Mutated trimeric RBD vaccines:a platform against variants of concern
《Signal Transduction and Targeted Therapy》2023年第5期2038-2040,共3页Belén Aparicio Juan J.Lasarte Pablo Sarobe 
supported by Instituto de Salud Carlos III,Fondo Europeo de Desarrollo Regional"Una manera de hacer Europa"under grant PI20/00260,Gobierno de Navarra under grant 0011-3597-2020-000024 to PS and by Paula&Rodger Riney Foundation to JJL.
He et al.recently reported in Nature Communications1 the development of a protein vaccine against SASR-CoV-2 Omicron variant consisting of a trimer of the spike protein receptor-binding domain(RBD)of the Delta variant...
关键词：VACCINE vaccines 
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants被引量：1
《Signal Transduction and Targeted Therapy》2023年第5期2345-2353,共9页Qian Wang Chenchen Yang Li Yin Jing Sun Wei Wang Hengchun Li Zhengyuan Zhang Si Chen Bo Liu Zijian Liu Linjing Shi Xiaolin Liu Suhua Guan Chunhua Wang Linbing Qu Ying Feng Xuefeng Niu Liqiang Feng Jincun Zhao Pingchao Li Ling Chen Nanshan Zhong 
supported by the National Natural Science Foundation of China (92269201,82061138006);Youth Innovation Promotion Association of CAS (2022361);National Key R&D Program of China (2021YFC2301700);Guangdong Provincial Key R&D Program (2021A1111090004,2022B1111070001);Science and Technology Planning Project of Guangdong Province (2009A081000003);Guangdong Basic and Applied Basic Research Foundation (2022B1515020059);Emergency Key Program of Guangzhou Laboratory (EKPG21-20,EKPG21-30-3);Talent program of Huangpu District (2021-2036).
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains administered via intramuscular injection.In this study,we...
关键词：NASAL IMMUNITY MUCOSAL 
A new generation M^(pro)inhibitor with potent activity against SARS-CoV-2 Omicron variants被引量：3
《Signal Transduction and Targeted Therapy》2023年第4期1970-1982,共13页Chong Huang Huiping Shuai Jingxin Qiao Yuxin Hou Rui Zeng Anjie Xia Lingwan Xie Zhen Fang Yueyue Li Chaemin Yoon Qiao Huang Bingjie Hu Jing You Baoxue Quan Xiu Zhao Nihong Guo Shiyu Zhang Ronggang Ma Jiahao Zhang Yifei Wang Ruicheng Yang Shanshan Zhang Jinshan Nan Haixing Xu Falu Wang Jian Lei Hin Chu Shengyong Yang 
National Natural Science Foundation of China[82130104,81930125,T2221004(S.Y.);22107081(B.Q.)],National Key R&D Program of China[2022YFC2303701 and 2021YFF0702004(J.L.)],1.3.5 project for disciplines of excellence;West China Hospital,Sichuan University[ZYXY21001(S.Y.);ZYYC21008(J.L.)],the fast-track grants of SARS-CoV-2 research,West China Hospital,Sichuan University[HX-2019-nCoV-053(S.Y.)];National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University[Z2021JC008(J.L.)];National Natural Science Foundation of China Excellent Young Scientists Fund(Hong Kong and Macao)[32122001(H.C.)];the Health and Medical Research Fund[CID-HKU1-5,COVID1903010-14,and 20190652(H.C.)];the Food and Health Bureau,The Government of the Hong Kong Special Administrative Region;the General Research Fund[17118621,17123920 and 17119122(H.C.)]of Research Grants Council,the Government of the Hong Kong Special Administrative Region;the National Program on Key Research Project of China[2020YFA0707500 and 2020YFA0707504(H.C.)].
Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health.Small molecule antivirals are an effective treatment strategy to fight against the viru...
关键词：treatment predominant POTENT 
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