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POTENT: 作品数：426被引量：902H指数：13; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘俊义梁健程颖刘永锋刘全海更多>>; 相关机构：北京大学中国医科大学附属第一医院上海医药工业研究院中国科学院上海生命科学研究院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

A novel generation of potent gamma-secretase modulators: Combat Alzheimer's disease and Down syndrome–associated Alzheimer's disease: 《Neural Regeneration Research》2026年第1期316-317,共2页Xu-Qiao Chen; Alzheimer's disease and Down syndrome:Down syndrome(DS)is a genetic disorder caused by the presence of an extra complete or partial chromosome 21.Over the past few decades,significant advancements in medical treatment...; 关键词：ALZHEIMER DOWN NURSING

Lactic acid bacteria act as potent interventions in improving hyperuricemia:a review: 《Food Science and Human Wellness》2025年第4期1212-1223,共12页Qingling Wu Xiaodong Pei Tiantian Gao Xiaoling Liu Chenghua Wang; funded by National Natural Science Foundation of China(32360564);the Natural Science and Technology Innovation Development Multiplication Plan of Guangxi University(2022BZRC010)。; Hyperuricemia(HUA)is characterized by elevated levels of uric acid(UA)in the bloodstream,resulting from either excessive production or insufficient excretion of UA within the body.If left untreated,progressive or pers...; 关键词：HYPERURICEMIA GOUT Lactic acid bacteria Uric acid-lowering mechanism

Mild photothermal therapy-enhanced nano-ferroptosis inducer for potent treatment of advanced prostate cancer: 《Nano Research》2025年第4期375-387,共13页Xiao Hu Fei Li Xin-Hang Qian Yu-Sen Zhang Shuai Ke Yun-Xia Jin Shuai Yuan Yuan-Yuan Zhang Rui Li Lei Cao Lang Rao Xian-Tao Zeng Ling-Ling Zhang; supported by the National Natural Science Foundation of China(Nos.12204358 and 62204214);the Young Top-notch Talent Cultivation Program of Hubei Province(X.-T.Z.);the Fundamental Research Funds for the Central Universities(No.2042023kf0091);the Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(No.ZNQNJC2022005).; Androgen deprivation therapy(ADT)and androgen receptor signaling inhibitors(ARSis)often have limited efficacy in patients with advanced prostate cancer(PCa)(especially AR-negative).Inducing ferroptosis in PCa cells is...; 关键词：prostate cancer ferroptosis mild photothermal therapy chemodynamic therapy mesoporous polydopamine

Erratum to"Pt-Se Hybrid Nanozymes with Potent Catalytic Activities to Scavenge ROS/RONS and Regulate Macrophage Polarization for Osteoarthritis Therapy": 《Research》2025年第1期477-478,共2页Hong Wei Hongjun Huang Haoqiang He Yuanming Xiao Lu Chun Zhiqiang Jin Hanyang Li Li Zheng Jinmin Zhao Zainen Qin; In the Research Article“Pt–Se hybrid nanozymes with potent catalytic activities to scavenge ROS/RONS and regulate macrophage polarization for osteoarthritis therapy”[1],the authors made an inadvertent error where 2...; 关键词：hybrid nanozymes erratum figure assembly processthe osteoarthritis therapy regulate macrophage polarization ROS macrophage polarization

ON POTENT ELEMENTS AND PSEUDO CLEAN RINGS: 《数学杂志》2025年第1期39-47,共9页DING Yan GAO Han-peng LIU Xin-yi YAN Zi-yi ZHANG Ting; Supported by National Natural Science Foundation of China(12301041)。; In this paper,potent index of an element and pseudo clean rings are considered.Some properties and examples of pseudo clean rings are given.We also show that Zm is pseudo clean for every 2≤m∈Z and pseudo clean rings...; 关键词：clean rings strongly J-clean rings pseudo clean rings potent elements

Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents: 《Chinese Chemical Letters》2025年第2期1-3,共3页Mianling Yang Meehyein Kim Peng Zhan; Despite the availability of effective antibacterial drugs,the increasing prevalence of antibiotic-resistant bacteria is primarily attributed to their excessive and inappropriate utilization.Antimicrobial resistance(AM...; 关键词：holds SYNTHESIS attributed

N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers:Design,structure-activity relationships and biological evaluations: 《Chinese Chemical Letters》2025年第2期228-233,共6页Jian Song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang; supported by the National Natural Science Foundation of China(Nos.82273782 and U2004123);Training Program for Young Key Teachers of Colleges and Universities in Henan Province(No.2023GGJS008)。; In this work,we employed a ring-opening strategy to develop a series of novel N-benzyl arylamide derivatives as tubulin polymerization inhibitors.Notably,13n(MY-1388)exhibited remarkable antiproliferative potency on f...; 关键词：TUBULIN Colchicine binding site CA-4 N-Benzyl arylamide Antiproliferative activities

Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one: 《World Journal of Diabetes》2025年第1期222-225,共4页Zi-Yu Zhao Pei-Li Luo Xia Guo Zheng-Wei Huang; Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes pathology.This condition could be protected by the upregulation of t...; 关键词：Polycytosine RNA-binding protein 1 Protein nanoparticle OSTEOBLAST Ferroptosis DIABETES

Pt–Se Hybrid Nanozymes with Potent Catalytic Activities to Scavenge ROS/RONS and Regulate Macrophage Polarization for Osteoarthritis Therapy被引量：1: 《Research》2024年第4期365-380,共16页Hong Wei Hongjun Huang Haoqiang He Yuanming Xiao Lu Chun Zhiqiang Jin Hanyang Li Li Zheng Jinmin Zhao Zainen Qin; supported by the Guangxi Science and Technology Major Project(grant no.GuikeAA19254002);the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(grant no.2023GXNSFBA026291);the National Natural Science Foundation of China(grant nos.81972120 and 81960414).; The activation of pro-inflammatory M1-type macrophages by overexpression of reactive oxygen species(ROS)and reactive nitrogen species(RONS)in synovial membranes contributes to osteoarthritis(OA)progression and cartila...; 关键词：Polarization CATALYTIC SYNERGISTIC

MicroRNAs as potent regulators in nitrogen and phosphorus signaling transduction and their applications: 《Stress Biology》2024年第1期221-242,共22页Yuzhang Yang Yanting Liang Chun Wang Yanwei Wang; supported by the National Natural Science Foundation of China(32371577 and 32071504);Beijing Natural Science Foundation(6232030).; Nitrogen(N)and phosphorus(Pi)are essential macronutrients that affect plant growth and development by influencing the molecular,metabolic,biochemical,and physiological responses at the local and whole levels in plants...; 关键词：miRNA NCRNA Plant Nitrogen PHOSPHORUS SIGNALING

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