VARIANTS

作品数：613被引量：1047H指数：14
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Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants
《Acta Pharmaceutica Sinica B》2025年第2期947-962,共16页Yi Wu Xiaoying Jia Namei Wu Xinghai Zhang Yan Wu Yang Liu Minmin Zhou Yanqiong Shen Entao Li Wei Wang Jiaming Lan Yucai Wang Sandra Chiu 
the National Virus Resource Center for kindly providing SARS-CoV-2 Omicron BA.1(CCPM-B-V-049-2112-18)and BA.5(NPRC2.062200006);supported by the National Key R&D Program of China(2020YFA0710700);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0490000,China);the National Natural Science Foundation of China(52025036,51961145109);the Shanghai“Belt and Road”Joint Laboratory Project(22490750200,China);This work was partially carried out at the USTC Center for Micro and Nanoscale Research and Fabrication.
Booster vaccinations are highly recommended in combating the SARS-CoV-2 Omicron variant and its subvariants.However,the optimal booster vaccination strategies and related immune mechanisms with different prior vaccina...
关键词：SARS-CoV-2 Omicron Subvariants Omicron-specific mRNA vaccine Commercial vaccines Booster vaccination Immune response 
COVID-19 vaccine updates for people under different conditions
《Science China(Life Sciences)》2024年第11期2323-2343,共21页Yijiao Huang Weiyang Wang Yan Liu Zai Wang Bin Cao 
supported by the National Natural Science Foundation of China(82241056,82170015,82100009,82030002);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-048);New Cornerstone Science Foundation,National Key R&D Program of China(2023YFC2306300);National Key R&D Program of China(2023YFC2306300).
SARS-CoV-2 has caused global waves of infection since December 2019 and continues to persist today.The emergence of SARS-CoV-2 variants with strong immune evasion capabilities has compromised the effectiveness of exis...
关键词：SARS-CoV-2 VACCINE variants of concern ELDERLY IMMUNOCOMPROMISED 
Trivalent SARS-CoV-2 virus-like particle vaccines exhibit broad-spectrum neutralization and protection against XBB.1 and BA.2.86 variants
《Virologica Sinica》2024年第5期836-839,共4页Lu Zhang Siyu Tian Jun Dai Yuanyuan Li Yu Zhou Yan Li Jiao Xu Shuyun Liu Zhiwei Lin Zhaoyong Zhang Jiantao Chen Peilan Wei Jingxian Zhao Jing Jin Yanqun Wang Jincun Zhao 
supported by a grant from the National Key R&D Program of China(2023YFC3041600 YW,the National Natural Science Foundation of China(82025001 JZ,92369113 YW,82172240 YW);Guangdong Basic and Applied Research Projects(2023B1515020040 YW,2021B1515130005 JZ,2021B1212030016 JD,2021A1111100009 JD);Science and Technology Planning Project of Guangzhou City(2023A04J1279 LZ);ZhongNanShan Medical Foundation of Guangdong Province(ZNSA-2020013 JZ);the Science and Technology Project of General Administration of Customs,P.R.China(2023HK065 LZ);State Key Laboratory of Respiratory Disease(SKLRD-Z-202214,SKLRD-OP-202309 YW,SKLRD-Z-202411 LZ);the Self-supporting Program of Guangzhou Laboratory(GZNL2023A01006,SRPG22-001);Guangzhou Medical University(YP2022005 YW);Korea Institute of Planning and Evaluation for Technology in Food,Agriculture and Forestry(IPET)through Animal Disease Management Technology Advancement Support Program,funded by the Ministry of Agriculture,Food and Rural Affairs(MAFRA)(122012-2,122060-2 JZ);the National Clinical Research Center for Respiratory Disease(BRD-NCRCRD,Guangzhou,Southern China).Patronus Biotech is a company researching virus-like particle display technology and vaccines.Yu Zhou and Jing Jin are named inventors on a patent invention relating to the described novel SARS-CoV-2 virus-like particle vaccine.All BALB/c mouse experiments complied with relevant ethical regulations for animal research and were approved by the LUYE PHARMA Animal Experimentation Ethics Committee.The K18-hACE2 mouse experiment was reviewed and approved by the Institutional Animal Care and Use Committees of Guangzhou Medical University(2023-0451).All authors declare that they have no conflict of interests.
Dear Editor,The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron subvariants(XBB.1,EG.5 and JN.1)and sublineages have been circulating globally with superior growth advantages over othe...
关键词：VACCINE vaccines acute 
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies被引量：2
《Signal Transduction and Targeted Therapy》2024年第6期2359-2361,共3页Xun Wang Shujun Jiang Wentai Ma Yanliang Zhang Pengfei Wang 
supported by funding from the National Natural Science Foundation of China(32270142 to P.W.);the Shanghai Rising-Star Program(22QA1408800 to P.W.);the Program of Science and Technology Cooperation with Hong Kong region,Macao region,and Taiwan region(23410760500 to P.W.);Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine(YBZX2022 to Y.Z.);NATCM’s Project of High-level Construction of Key TCM Disciplines;support from AI for Science project of Fudan University(XM06231724);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(No.SKLGE-2304);Xiaomi Young Talents Program.
Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of s...
关键词：evolve NEUTRALIZATION VARIANTS 
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2312-2323,共12页Xian Li Mengxin Xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen 
National Key R&D program of China(Grant number:2022YFC2304204 to Y.-Q.C.,2021YFC2302602 to J.Y.);National Natural Science Foundation of China(grant number:82341041 to H.Y.and 92169104 to Y.-Q.C.);Shanghai Science and Technology Innovation Action Plan(Grant number:22Y11901000 to Q.W.);Shenzhen Science and Technology Program(Grant number:RCJC20210706092009004,JCYJ2020010914243811,KQTD20200820145822023 to Y.-Q.C.)supported this work in whole or in part.
Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic.Here,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple rece...
关键词：VACCINATION VACCINE SUSTAINED 
Delta(B.1.617.2)inactivated vaccine candidate elicited neutralizing antibodies to SARS-CoV-2 and circulating variants in rhesus macaques
《Virologica Sinica》2023年第4期627-630,共4页Yanjun Zhang Haiyan Mao Ju Li Jianhua Li Chen Huang Jiaxuan Li Minglei Chu Fengbo Xue Linhui Wang Zhongbiao Fang Zhen Wang Jinan Wu Keda Chen 
supported by the Science and Technology Program of Zhejiang Province (#2022C03017);Key Research and Development Program of Zhejiang Province (#2021C03044);Major Health Science and Technology Projects of Zhejiang Province (#WKJ-ZJ-2105);National Key R&D Program of China (#2021YFC2301200).
Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has resulted in 763 million cases and over 6 million deaths as of April 2023.Given the high prevalence and widespread distribution of coronaviruses,the geneti...
关键词：ANTIBODIES VACCINE 
Contamination and Transmission of SARS-CoV-2 Variants in Cold-Chain Food and Food Packaging
《China CDC weekly》2023年第22期485-491,共7页Gang Li Yeru Wang Zhenhua Wang Yibaina Wang Yan Qi Li Bai Zhaoping Liu Ning Li 
National Key Research and Development Program of China(Grant numbers 2022YFF1103100 and 2019YFC1605900);2022 Strategic Research and Consulting Project of Chinese Academy of Engineering.
INTRODUCTION The emergence of coronavirus disease 2019(COVID-19)has posed a significant threat to global health and well-being.Vaccination serves as a vital strategy in preventing and mitigating the severity of clinic...
关键词：ACUTE VACCINE RESPIRATORY 
Real-world effectiveness of mRNA COVID-19 vaccines in the elderly during the Delta and Omicron variants:Systematic review
《World Journal of Meta-Analysis》2023年第5期167-180,共14页Harvey Palalay Riddhi Vyas Barbara Tafuto 
BACKGROUND As of 31 December 2022,there were over 6.6 million coronavirus disease 2019(COVID-19)deaths and over 651 million cases across 200 countries worldwide.Despite the increase in vaccinations and booster shots,C...
关键词：COVID-19 mRNA Vaccine EFFECTIVENESS Elderly DELTA Omicron Systematic review 
Mutated trimeric RBD vaccines:a platform against variants of concern
《Signal Transduction and Targeted Therapy》2023年第5期2038-2040,共3页Belén Aparicio Juan J.Lasarte Pablo Sarobe 
supported by Instituto de Salud Carlos III,Fondo Europeo de Desarrollo Regional"Una manera de hacer Europa"under grant PI20/00260,Gobierno de Navarra under grant 0011-3597-2020-000024 to PS and by Paula&Rodger Riney Foundation to JJL.
He et al.recently reported in Nature Communications1 the development of a protein vaccine against SASR-CoV-2 Omicron variant consisting of a trimer of the spike protein receptor-binding domain(RBD)of the Delta variant...
关键词：VACCINE vaccines 
Evaluation of immunoprotection against coronavirus disease 2019:Novel variants,vaccine inoculation,and complications
《Journal of Pharmaceutical Analysis》2023年第1期1-10,共10页Congshan Jiang Kaichong Jiang Xiaowei Li Ning Zhang Wenhua Zhu Liesu Meng Yanmin Zhang Shemin Lu 
support from the National Natural Science Foundation of China(Grant Nos.:81970029,81974014,82211530115,and 81470452),China Postdoctoral Science Foundation(Project No.:2021M702591),the Natural Science Foundation of Shaanxi Province(Project No.:2021JQ-024),Fundamental Research Funds for the Central Universities(Project No.:xjh012020026),Xi'an Health Commission(COVID-19 special project),Xi'an Talent Program(Project No.:XAYC200023),and research funds of Xi'an Children's Hospital(Project No.:2020A03).
The strikingly rapidly mutating nature of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)genome has been a constant challenge during the coronavirus disease 2019(COVID-19)pandemic.In this study,various...
关键词：COVID-19Etiological diagnosisImmunoprotectionSARS-CoV-2 variantsVaccineComplications 
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