ABERRANT

作品数：201被引量：605H指数：12
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相关领域：医药卫生更多>>
相关作者：杨音杨楠孙鸾张欣孙玉洁更多>>
相关机构：第二军医大学第三军医大学西南医院南京医科大学湖州市第三人民医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation被引量：1
《Signal Transduction and Targeted Therapy》2024年第6期2702-2715,共14页Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim 
supported in part by the National Research Council of Science&Technology grant by the Korea government(CRC-16-01-KRICT);the Korea Research Institute of Chemical Technology(KRICT)(KK2333-20);the National Research Foundation of Korea(NRF-2021M3E5E3080540,RS-2023-00248135);the BK 21 FOUR Program by the Chungnam National University Research Grant,2023.
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan damage.However,knowledge regarding SARS-CoV-2-induced cellular alterations is lim...
关键词：alterations ABERRANT thereby 
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression被引量：2
《Signal Transduction and Targeted Therapy》2024年第1期279-294,共16页Liping Chen Shihao Zhu Tianyuan Liu Xuan Zhao Tao Xiang Xiao Hu Chen Wu Dongxin Lin 
funded by the National Natural Science Foundation of China(81988101 to D.L.and to C.W.);National Key Research and Development Program of China(2021YFC2501000 to D.L.);Medical and Health Technology Innovation Project of Chinese Academy of Medical Sciences(2021-I2M-1-013 to D.L.and to C.W.,2022-I2M-2-003 and 2022-I2M-JB-002 to D.L.);Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023027 to C.W.).
Epithelial-mesenchymal transition(EMT)and proliferation play important roles in epithelial cancer formation and progression,but what molecules and how they trigger EMT is largely unknown.Here we performed spatial tran...
关键词：ESOPHAGEAL TP53 SQUAMOUS 
Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target
《Signal Transduction and Targeted Therapy》2023年第11期5151-5152,共2页Gerrit Wolters-Eisfeld Thilo Hackert Cenap Güngör 
In a recently published Nature article,Lee et al.investigated distinct metabolic dependencies of pancreatic ductal adenocarcinoma(PDA)cells compared to normal tissue,and discovered that PDA cells exhibited a unique re...
关键词：SYNTHESIS DEN depen 
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits被引量：2
《Signal Transduction and Targeted Therapy》2023年第7期3427-3442,共16页Liying Chen Yingwei Xu Heming Cheng Zhongxia Li Nanxi Lai Menghan Li Yeping Ruan Yang Zheng Fan Fei Cenglin Xu Jiao Ma Shuang Wang Yan Gu Feng Han Zhong Chen Yi Wang 
This project was supported by grants from the National Natural Science Foundation of China(82022071,81973298 and 82204350);the National Key Research and Development Program of China(2020YFA0803902);the Natural Science Foundation of Zhejiang Province(LD22H310003).
Temporal lobe epilepsy(TLE),one common type of medically refractory epilepsy,is accompanied with altered adult-born dentate granule cells(abDGCs).However,the causal role of abDGCs in recurrent seizures of TLE is not f...
关键词：EPILEPSY seizures MAINTAIN 
p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer被引量：4
《Signal Transduction and Targeted Therapy》2020年第1期1792-1803,共12页Xiaoli Wen Jing Wan Qizhi He Mengfei Wang Shuangdi Li Mei Jiang Zhen Qian Binya Liu Wen Lu Kai Wang Kun Gao Xiaoping Wan 
supported by the National Natural Science Foundation of China(numbers 91954106 and 81872109 to K.G.,number 81672574 to X.W.,and number 81601247 to B.L.);the Shanghai Municipal Medical and Health Discipline Construction Projects(number 2017ZZ02015 to X.W.);the Natural Science Foundation of Shanghai(number 18ZR1430100 to K.G.);the Shanghai Clinical Medicine Field Project of Science and Technology Innovation Action Program(number 17411951600 to X.W.).
The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins(GAPs)that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases.p190A is a potent and widely ex...
关键词：ENDOMETRIAL MALIGNANT cancer 
Lyn prevents aberrant inflammatory responses to Pseudomonas infection in mammalian systems by repressing a SHIP-1-associated signaling cluster被引量：2
《Signal Transduction and Targeted Therapy》2016年第1期10-20,共11页Rongpeng Li Lizhu Fang Qinqin Pu Ping Lin Austin Hoggarth Huang Huang Xuefeng Li Guoping Li Min Wu 
This work was supported by National Institute of Health(AI109317-01A1 and AI109373-01).
The pleiotropic Src kinase Lyn has critical roles in host defense in alveolar macrophages against bacterial infection,but the underlying mechanism for Lyn-mediated inflammatory response remains largely elusive.Using m...
关键词：SHIP INFLAMMATORY STAT3 
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