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作品数：424被引量：1091H指数：17
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相关机构：中国气象科学研究院中国科学技术大学吉林大学北京师范大学更多>>
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Aging and aging-related diseases:from molecular mechanisms to interventions and treatments被引量：18
《Signal Transduction and Targeted Therapy》2023年第1期77-116,共40页Jun Guo Xiuqing Huang Lin Dou Mingjing Yan Tao Shen Weiqing Tang Jian Li 
supported by funds from the National Key R&D Program of China(2018YFC2000100 and 2021YFE0114200);the National Natural Science Foundation of China(81770228,81770858,81600618,and 82271597);the Beijing Natural Science Foundation(7212086);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-050).
Aging is a gradual and irreversible pathophysiological process.It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases,including neurodegenerativ...
关键词：DISEASES alterations AGING 
Hypocretin neuron hyperexcitability in the hypothalamus:a newly discovered culprit in aging-related sleep impairment被引量：1
《Signal Transduction and Targeted Therapy》2022年第8期2648-2649,共2页Tianbai Li Congcong Jia Weidong Le 
supported by the National Natural Science Foundation of China(NSFC 82001483 and 82101560).
The recent research published in Science by Li et al.1 provides compelling evidence that the hyperexcitability of arousalpromoting hypocretin(Hcrt,also called orexin)neurons is closely associated with sleep instabilit...
关键词：SLEEP IMPAIRMENT al. 
MtDNA mutations and aging--not a closed case after all?
《Signal Transduction and Targeted Therapy》2021年第3期555-556,共2页Alexander M.Wolf 
In a recent paper in Nature Cancer,Smith et al.demonstrate that mitochondrial DNA(mtDNA)mutations can confer a growth advantage to intestinal tumors by remodeling cell metabolism,particularly toward elevated de novo s...
关键词：al. METABOLISM ELEVATED 
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