the National Key Technology Research and Development Program of China(2018YFA0900300 and 2022YFA0911800);the National Natural Science Foundation of China(21978071 and U1932141);the Key Science and Technology Innovation Project of Hubei Province(2021BAD001);2022 Joint Projects between Chinese and CEEC’s Universities(202004);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Province(2018R01014);the Innovation Base for Introducing Talents of Discipline of Hubei Province(2019BJH021)。
High-quality genome-scale metabolic models(GEMs)could play critical roles on rational design of microbial cell factories in the classical Design-Build-Test-Learn cycle of synthetic biology studies.Despite of the const...