supported by the Natural Science Foundation of Hebei Province (H2020206226);Hebei Province Science and Technology Support Program (18277756D);the Science and Technology Research Project of Hebei Higher Education Institutions (ZD2022010);High-level Talent Funding Project of Hebei (C20231141) to W.W。
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanor...
supported by grants from the National Natural Science Fund of China(32072834,31972665);Special fund support for Taishan Scholar Project(H.H,tspd20181207);Shandong Provincial Natural Science Foundation,China(ZR2021MC050),and Jinan Innovation Team(202228060).
The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in metabolism.However,its function in the antiviral innate immune response remains to be determined.In this st...
Acknowledgements This study was supported by the National Natural Science Foundation of China (No 21372238 and 21572244 to Wei HUANG). Gao-jie SONG was supported by a State Education Ministry grant for Returned Overseas Chinese Scholars (No X-0801-15-020). We thank the staff at Beamline BL19U2 of the National Center for Protein Science Shanghai (NCPSS) at the Shanghai Synchrotron Radiation Facility (SSRF) for help with SAXS data collection. We would also like to thank colleagues at the iHuman Institute for providing technical support and helpful discussions, and Jack SKINNER for his critical reading of this manuscript.
CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a spli...
Supported by National Natural Science Foundation of China,No.81101837;Research Fund for the Doctoral Program of Higher Education of China,No.20110101120129;Zhejiang Medical Health Science and Technology Plan,No.2013KYB124
AIM: To investigate the mechanism underlying the promoting role of CD97 in gastric cancer cell proliferation and invasion. METHODS: Two types of exosomes released by gastric cancer cells with high(SGC/wt) or low(SGC/k...