Colorectal cancer remains one of the commonest and most lethal malignancies worldwide(1).Up to 80%of patients with colorectal cancer develop liver metastases(CRLM),which are the main factor limiting survival(1,2).Desp...
We extend our gratitude to Dr.Liu and colleagues for their valuable feedback and comments on our article(1).We developed a machine learning model which predicted the outcomes of surgical treatment for colorectal liver...
This work was supported in part by grant NIH-R01CA/DK80982-01 from the National Institutes of Health and a grant the FAMRI.
Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahe...
In patients with definitively unresectable colorectal liver metastases,whether the primary tumor should be resected prior to chemotherapy is an old question.Several retrospective studies(1-5)and a meta-analysis with i...
Life expectancy of patients with colorectal liver metastasis(CRLM)significantly improved over the last decades due to the induction of multimodal effective treatment strategies including perioperative chemotherapy and...
More than 50%of patients will develop colorectal cancer(CRC)liver metastases(CRCLM)during the course of their disease,while 15-25%of patients will have metastatic disease present at the time of initial diagnosis.Resec...
Management of patients with synchronous colorectal liver metastases(SCRLM)has transformed dramatically over the past 2 decades(1-3).A step-by-step,patient tailored approach as orchestrated by a multidisciplinary tumor...
With advancements in surgical techniques,locoregional therapy and systemic therapy,patients suffering from colorectal cancer with liver metastasis now have numerous therapeutic options for local and systemic disease c...
Adenocarcinoma of the colon and rectum(CRC)is the second leading cause of cancer-related mortality.Surgical resection of disease offers the best long-term survival.Unfortunately,>50%of patients have liver metastases a...
Contrary to most solid metastatic cancers,metastatic colorectal cancer could be cured by surgical removal of the metastasis in the context of lung or liver metastases.Large retrospective studies performed 20 years ago...