CYTOCHROME_P450

作品数：271被引量：809H指数：13
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  • 期刊=Chinese Journal of Natural Medicinesx
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Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III
《Chinese Journal of Natural Medicines》2024年第4期291-292,共2页DU Jinfa LIAO Pan LU Xu 
Paclitaxel,a tetracyclic diterpenoid,has garnered attention for its potent anti-cancer properties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its...
关键词：Paclitaxel biosynthesis Baccatin III Cytochrome P450 Taxane oxetanase 1 Heterologous reconstitution 
Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza被引量：2
《Chinese Journal of Natural Medicines》2023年第12期938-949,共12页REN Li LUO Linglong HU Zhimin MA Ying WANG Jian CHENG Yatian JIN Baolong CHEN Tong TANG Jinfu CUI Guanghong GUO Juan HUANG Luqi 
This work was supported by the National Key R&D Program of China(Nos.2020YFA0908000,2018YFA0900600);the National Natural Science Foundation of China(Nos.82003904,81822046);the Fundamental Research Funds for the Central public welfare research institutes(No.ZZ13-YQ-083);a Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A04110);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202005);a key project at central government level(the ability to establish sustainable use of valuable Chinese medicine resources;2060302,China).
Danshen,the dried roots and rhizomes of Salvia miltiorrhiza Bunge(S.miltiorrhiza),is widely used in the treatment of cardiovascular and cerebrovascular diseases.Tanshinones,the bioactive compounds from Danshen,exhibit...
关键词：Salvia miltiorrhiza TANSHINONE Biosynthetic pathway Cytochrome P450 HYDROXYLATION Neocryptotanshinone 
Identification of a cytochrome P450 from Tripterygium hypoglaucum(Levl.)Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis被引量：2
《Chinese Journal of Natural Medicines》2022年第9期691-700,共10页CHEN Xiao-Chao LU Yun LIU Yuan ZHOU Jia-Wei ZHANG Yi-Feng GAO Hai-Yun LIDan GAO Wei 
supported by the National Key R&D Program of China(No.2020YFA0908000);the National Natural Science Foundation of China(Nos.81773830 and 81973418);the Key Project at Central Government Level:the ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302-1806-03),and the National Program for Special Support of Eminent Professionals.
Tripterygium hypoglaucum(Levl.)Hutch,a traditional Chinese medicinal herb with a long history of use,is widely distributed in China.One of its main active components,celastrol,has great potential to be developed into ...
关键词：Tripterygium hypoglaucum Cytochrome P450 Polpunonic acid CELASTROL BIOSYNTHESIS 
Advances in biosynthesis of triterpenoid saponins in medicinal plants被引量：13
《Chinese Journal of Natural Medicines》2020年第6期417-424,共8页YAO Lu LU Jun WANG Juan GAO Wen-Yuan 
the Central Significant Increase or Decrease Program of China(No.2060302-1604-05);NSFC(No.81703639)。
In recent years, biosynthesis of triterpenoid saponins in medicinal plants has been widely studied because of their active ingredients with diverse pharmacological activities. Various oxidosqualene cyclases, cytochrom...
关键词：Medicinal plant Cytochrome P450 monooxygenases Uridine diphosphate glucuronosyltransferases Transcription factor Triterpenoid saponins 
Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus被引量：11
《Chinese Journal of Natural Medicines》2019年第11期858-870,共13页ZHOU Qi-Hang ZHU Ya-Di ZHANG Feng SONG Yun-Qing JIA Shou-Ning ZHU Liang FANG Sheng-Quan GE Guang-Bo 
supported by the NSF of China(Nos.81922070,81973286,81773687);the National Key Research and Development Program of China(No.2017YFC1700200,2017YFC1702000);Program of Shanghai Academic/Technology Research Leader(No.18XD1403600);Shuguang Program(No.18SG40);Program for applied basic research of Qinghai Provincial Science and Technology Department(No.2017-ZJ-713);Program for Innovative Leading Talents of Qinghai Province(2018&2019)
Psoraleae Fructus(the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psorale...
关键词：Psoraleae Fructus Cytochrome P450 enzymes(CYPs) Uridine diphosphate-glucuronosyltransferases(UGTs) Herb-drug interactions(HDI) Herb-endobiotic interactions(HEI) 
Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines
《Chinese Journal of Natural Medicines》2017年第9期695-702,共8页ZHUANG Xiao-Mei CHEN Lin TAN Yan YANG Hai-Ying LU Chuang GAO Yue LI Hua 
supported by Chinese National Science & Technology Major Special Project on Major New Drug Innovation(Nos.2008ZXJ09006001 and 2015ZX09J15104);National Natural Science Foundation of China(No.81130067)
Ferulic acid(FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. ...
关键词：Ferulic acid Herb-drug interaction Reaction phenotyping Human liver microsomes 
Effects of Ziziphus jujuba fruit extracts on cytochrome P450(CYP1A2) activity in rats被引量：1
《Chinese Journal of Natural Medicines》2015年第8期588-594,共7页JING Xin-Yue PENG Yun-Ru WANG Xin-Min DUAN Jin-Ao 
supported by the National Basic Research Program of China(973 Program)(Nos.2011CB505300 and 2011CB505303);Natural Science Foundation of China(No.81303018);Natural Science Foundation for Colleges and Universities in Jiangsu Province(No.13KJB360006);Natural Science Foundation of Nanjing University of Chinese Medicine(No.12XZR17)
Drug-drug interactions have become a serious problem in the clinic, since plant-based medicines are extensively used. The present study investigated the effects of Ziziphusjujuba fruit （Z J） extract on the pharmacok...
关键词：Ziziphusjujuba CYP1A2 PHENACETIN Aeetaminophen Hepatic microsomes Plant drug-drug interactions 
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