云南高校图书馆联盟文献共享服务平台- CYTOCHROME

CYTOCHROME_P450: 作品数：271被引量：809H指数：13; 导出分析报告; 相关作者：汤致强周江泉李燕陆宏崔景荣更多>>; 相关机构：中国医学科学院肿瘤医院中南大学湖州市第三人民医院台湾大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Design and engineering of logic genetic-enzymatic gates based on the activity of the human CYP2C9 enzyme in permeabilized Saccharomyces cerevisiae cells: 《Synthetic and Systems Biotechnology》2024年第3期406-415,共10页Rana Azeem Ashraf Matthias Bureik Mario Andrea Marchisio; Gene circuits allow cells to carry out complex functions such as the precise regulation of biological metabolic processes.In this study,we combined,in the yeast S.cerevisiae,genetic regulatory elements with the enzyma...; 关键词：Cytochrome P450 Drug metabolism Budding yeast DICLOFENAC Synthetic biology CORM-401 Boolean gates

Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst被引量：1: 《Synthetic and Systems Biotechnology》2023年第4期741-748,共8页Chixiang Sun Baodong Hu Yanchun Li Zhimeng Wu Jingwen Zhou Jianghua Li Jian Chen Guocheng Du Xinrui Zhao; supported by the National Key Research and Development Program of China(2019YFA0906400);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-08);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_2486);We thank Prof.Shengying Li(Shandong University,China)for providing plasmids pET28a-SelFdx1499 and pET28a-SelFdR0978.; Deoxycholic acid(DCA)has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat.The hydroxylated product(6β-OH DCA)was developed to improve the solubility and pharmaceutic proper...; 关键词：OleP Deoxycholic acid HYDROXYLATION Redox partners Whole-cell catalysis

Enzymatic synthesis of indigo derivatives by tuning P450 BM3 peroxygenases: 《Synthetic and Systems Biotechnology》2023年第3期452-461,共10页Li Ma Tianjian Sun Yunjie Liu Yue Zhao Xiaohui Liu Yuxuan Li Xinwei Chen Lin Cao Qianqian Kang Jiawei Guo Lei Du Wei Wang Shengying Li; the National Key Research and Development Program of China(2019YFA0905100);the National Natural Science Foundation of China(32025001,32071266 and 32170088);the Shandong Provincial Natural Science Foundation(ZR2019ZD20);the State Key Laboratory of Microbial Technology Open Projects Fund(Project NO.M2022-01).; Indigoids,a class of bis-indoles,have long been applied in dyeing,food,and pharmaceutical industries.Recently,interest in these‘old’molecules has been renewed in the field of organic semiconductors as functional bui...; 关键词：Cytochrome P450 enzymes P450 BM3 peroxygenase Indigoids DYESTUFF Organic electronics

Applications of protein engineering in the microbial synthesis of plant triterpenoids: 《Synthetic and Systems Biotechnology》2023年第1期20-32,共13页Yan Luo Yaozhu Jiang Linhao Chen Chun Li Ying Wang; support from the National Key Research and Development Program of China (2019YFA0905700,2018YFA0901800);the National Natural Science Foundation of China (22078020);Young Elite Scientists Sponsorship Program by CAST (2019QNRC001).; Triterpenoids are a class of natural products widely used in fields related to medicine and health due to their biological activities such as hepatoprotection,anti-inflammation,anti-viral,and anti-tumor.With the advan...; 关键词：Oxidosqualene cyclase Cytochrome P450 UDP-Glycosyltransferase TRITERPENOIDS Protein engineering

Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae: 《Synthetic and Systems Biotechnology》2022年第4期1142-1147,共6页Lan Jiang Kangjie Lv Guoliang Zhu Zhi Lin Xue Zhang Cuiping Xing Huanting Yang Weiyan Zhang Zhixin Wang Chengwei Liu Xudong Qu Tom Hsiang Lixin Zhang Xueting Liu; the financial support from the National Key Research and Development Program of China(2020YFA0907800 and 2019YFA0906200);the National Natural Science Foundation of China(21907031,81903529,21977029,31720103901,21877124);the Open Project Funding of the State Key Laboratory of Bioreactor Engineering;the 111 Project(B18022);Genome sequencing and assembly of strain DV17020 were supported by funding from the Natural Science and Engineering Research Council of Canada to Prof.T.Hsiang.; The chemical diversity of terpenoids is typically established by terpene synthase-catalyzed cyclization and diversified by post-tailoring modifications.Fungal bifunctional terpene synthase(BFTS)associated P450 enzymes...; 关键词：Bifunctional terpene synthases Norditerpenoids Cytochrome P450 Aspergillus oryzae Heterologous expression

Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation: 《Synthetic and Systems Biotechnology》2022年第3期887-899,共13页Yu Yan Jing Wu Guipeng Hu Cong Gao Liang Guo Xiulai Chen Liming Liu Wei Song; supported by the National Key R&D Program of China(Grant No.2021YFC2100100 and 2021YFC2102000);the General Program of National Natural Science Foundation of China(Grant No.22178146).; Cytochrome P450 enzymes(CYPs)catalyze a series of C-H and C=C oxygenation reactions,including hydroxylation,epoxidation,and ketonization.They are attractive biocatalysts because of their ability to selectively introdu...; 关键词：BIOCATALYSIS P450 enzymes C-H and C=C oxygenation

PCPD:Plant cytochrome P450 database and web-based tools for structural construction and ligand docking被引量：3: 《Synthetic and Systems Biotechnology》2021年第2期102-109,共8页Hui Wang Qian Wang Yuqian Liu Xiaoping Liao Huanyu Chu Hong Chang Yang Cao Zhigang Li Tongcun Zhang Jian Cheng Huifeng Jiang; supported by grants from the National Key R&D Program of China(2020YFC1316400 and No.2019YFA0905700);the National Natural Science Foundation of China(NSFC,Grant Nr.31670100);as well as grants by the NSFC(81560621);the National Science Fund for Excellent Young Scholars(31922047).; Plant cytochrome P450s play key roles in the diversification and functional modification of plant natural products.Although over 200,000 plant P450 gene sequences have been recorded,only seven crystalized P450 genes s...; 关键词：Plant P450 database Homologous modeling Ligand docking DATABASE Web service

Discovery and modification of cytochrome P450 for plant natural products biosynthesis被引量：4: 《Synthetic and Systems Biotechnology》2020年第3期187-199,共13页Xiaonan Liu Xiaoxi Zhu Hui Wang Tian Liu Jian Cheng Huifeng Jiang; This work was supported by grants from the National Key R&D Program of China(No.2019YFA0905700)to J.C.;the National Natural Science Foundation of China(NSFC;Grant No.31901026);the China Postdoctoral Science Foundation(Grant No.2019M661032)to X.L;Tianjin Science and technology plan project(Grant No.19PTZWHZ00060);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-007&TSBICIP-KJGG-002)to H.J.; Cytochrome P450s are widespread in nature and play key roles in the diversification and functional modification of plant natural products.Over the last few years,there has been remarkable progress in plant P450s ident...; 关键词：P450 enzymes Plant natural products Synthetic biology

Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana被引量：2: 《Synthetic and Systems Biotechnology》2020年第3期236-243,共8页Fengwei Li Li Ma Xingwang Zhang Jingfei Chen Feifei Qi Yinyue Huang Zepeng Qu Lishan Yao Wei Zhang Eung-Soo Kim Shengying Li; This work was supported by the National Key Research and Development Program of China(2019YFA0905100 to S.L.);the National Natural Science Foundation of China(31800664 to F.L.,31872729 to S.L.and 31600045 to L.M.);General Support from China Postdoctoral Science Foundation(Grant No.2017M622293 to F.L.);Shandong Provincial Natural Science Foundation,China(ZR2019ZD22 to S.L.and ZR2016CQ05 to L.M.);the Applied Basic Research Programs of Science and Technology of Qingdao(17-1-1-60-jch to L.M.);National Research Foundation of Korea(No.NRF-2017R1A2A2A05069859 to E.-S.K.).; The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A(CsA)primarily at the 4th N-methyl leucine(MeLeu4),giving r...; 关键词：Cytochrome P450 monooxygenase Crystal structure Cyclosporine A Regioselectivity Hair growth stimulator

Rational and semi-rational engineering of cytochrome P450s for biotechnological applications被引量：5: 《Synthetic and Systems Biotechnology》2018年第4期283-290,共8页Lian-Hua Xu Yi-Ling Du; fundamental research funds from the National Natural Science Foundation(grant number 81402810)。; The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism.Due to their broad substrate scope and catalytic versatility...; 关键词：Cytochrome P450 Protein engineering Rational design Crystal structure

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