DEVELOPMENTAL

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination
《Neural Regeneration Research》2025年第2期394-401,共8页Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza 
supported by Catalan Government,Nos.2014SGR344(to JT),2017SGR704(to JT),2021SGR01214(to MAL);MCIN/AEI/10.13039/501100011033/by“ERDF A way of making Europe,”Nos.SAF2015-67143(to JT),PID2019-106332GB-I00(to JT and MAL)and PID2022-141252NB-I00(to MAL).
During the development of the nervous system,there is an overproduction of neurons and synapses.Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their el...
关键词：acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB 
Developmental exposure to thyroid disruptors:misprogramming of the brain's stem cells in later life?
《Neural Regeneration Research》2023年第3期527-528,共2页Pieter Vancamp Sylvie Remaud 
supported by the European Union’s Horizon 2020 contract ATHENA(grant No.666869);ENDpoiNTs(grant No.825759);supported by the European Thyroid Association(ETA);the Fondation pour la Recherche Médicale(FRM grant No.SPF201909009111)。
Introduction:Ever since the discovery of neural stem cells(NSCs)in the adult mammalian brain,scientists have been trying to decipher which signals govern their turnover and lineage commitment to generate neurons and g...
关键词：ENDOGENOUS HOMEOSTASIS PROGRAMMING 
Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats被引量：4
《Neural Regeneration Research》2022年第11期2518-2525,共8页Yang Jiao Yue-Tong Sun Nai-Fei Chen Li-Na Zhou Xin Guan Jia-Yi Wang Wen-Juan Wei Chao Han Xiao-Lei Jiang Ya-Chen Wang Wei Zou Jing Liu 
the National Natural Science Foundation of China,No.81471308(to JL);Stem cell Clinical Research Registry Program,No.CMR-20161129-1003(to JL);Liaoning Province Excellent Talent Program Project of China,No.XLYC1902031(to JL);Dalian Innovation Fund of China,No.2018J11CY025(to JL);National Defense Science and Technology New Special Zone Contract,No.19-163-00-kx-003-001-01(to JL)。
Administration of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)is believed to be an effective method for treating neurodevelopmental disorde rs.In this study,we investigated the possibility of hUC-MSCs...
关键词：developmental brain disease model disease-associated astrocytes intranasal administration LIPOPOLYSACCHARIDE maternal immune activation neonatal brain injury neuroplasticity repair polypyrimidine tract-binding protein-1 stem cell therapy umbilical cord-derived mesenchymal stem cells 
Postnatal therapeutic approaches in genetic neurodevelopmental disorders
《Neural Regeneration Research》2021年第3期414-422,共9页Gilad Levy Boaz Barak 
supported by grants from Fritz Thyssen Stiftung,Brain Boost Innovation Center by Sagol School of Neuroscience at TAU,and SPARK Tel Aviv;supported by the Eshkol Fellowship from The Ministry of Science and Technology;the recipient of The Alon Fellowship for outstanding young researchers awarded by the Israeli Council for Higher Education。
Genetic neurodevelopmental disorders are characterized by abnormal neurophysiological and behavioral phenotypes,affecting individuals worldwide.While the subject has been heavily researched,current treatment options r...
关键词：adeno-associated virus CRISPR-Cas9 developmental window genetic therapy mouse models neurodevelopmental disorders non-human primates preclinical studies 
Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult spatial learning ability被引量：7
《Neural Regeneration Research》2020年第5期880-886,共7页Dan Lyu Ning Tang Andrew W. Womack Yong-Jin He Qing Lin 
supported by the National Natural Science Foundation of China,No.81200851(to DL);the National Institutes of Health of the USA,No.NS 040723(to QL)
Ketamine exposure can lead to selective neuroapoptosis in the developing brain.p66ShcA,the cellular adapter protein expressed selectively in immature neurons,is a known pro-apoptotic molecule that triggers neuroapopto...
关键词：caspase-3 DEVELOPMENTAL neuroapoptosis hippocampus KETAMINE MORRIS water MAZE N-METHYL-D-ASPARTATE acid receptors p66ShcA SPATIAL learning 
Developmental dependence for functional eye regrowth in Xenopus laevis
《Neural Regeneration Research》2018年第10期1735-1737,共3页Cindy X.Kha Kelly Ai-Sun Tseng 
supported by grants from the National Institutes of Health(P20GM103440);the University of Nevada,Las Vegas(a Faculty Opportunity Award and a doctoral dissertation graduate assistantship)to KAST
Introduction：A key challenge in designing tissue repair strategies is knowing whether and how developmental mechanisms are used for successful repair of mature/adult tissues.Although it is known that developmental co...
关键词：Developmental dependence for functional eye regrowth in Xenopus laevis FIGURE RI 
Developmental process of the arcuate fasciculus from infancy to adolescence: a diffusion tensor imaging study被引量：3
《Neural Regeneration Research》2016年第6期937-943,共7页Hyeong Jun Tak Jin Hyun Kim Su Min Son 
supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology,No.2012-013997
We investigated the radiologic developmental process of the arcuate fasciculus（AF） using subcomponent diffusion tensor imaging（DTI） analysis in typically developing volunteers. DTI data were acquired from 96 conse...
关键词：tracts tensor younger older developmental maturation typically asymmetry anisotropy fractional 
Developmental transcription factors in age-related CNS disease: a phoenix rising from the ashes?
《Neural Regeneration Research》2016年第1期64-65,共2页Robert B.White Meghan G.Thomas 
Raine Foundation Priming Grant;Australian Research Council Discovery Project Grant(DP772899);Cancer Council WA Suzanne Cavanagh Early Career Research Grant
Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its biology.The temporal and spatial position of a cell from the very earliest stages of ...
关键词：landscape earliest mature doubt exposed developmental substantia nigra hydroxylase dopamine 
Electric stimulation at sciatic nerve evokes long-term potentiation of cornu dorsale medullae spinalis field potential in rats at various developmental phases被引量：1
《Neural Regeneration Research》2007年第7期385-389,共5页Jiang Wu Dan Shu Qisheng Hu 
BACKGROUND： Long-term potentiation of cornu dorsale medullae spinalis field potential in adult rats has already been reported; however, there is lack of correlated researches on naenonate, infant and adult rats which...
关键词：long-term potentiation spinal cord electric stimulation 
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