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作品数：218被引量：717H指数：11
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Endothelial FOSL1 drives angiotensin Ⅱ-induced myocardial injury via AT1R-upregulated MYH9
《Acta Pharmacologica Sinica》2025年第4期922-939,共18页Wen-jing Zhao Yi Qian Yi-feng Zhang Ai-hua Yang Jia-xin Cao Hong-yan Qian Yi Liu Wei-zhong Zhu 
funded by grants(82102784 and 81770440)from the National Natural Science Foundation of China;funded by Health Committee of Nantong(MS2023055 and MSZ2023041);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_3440).
Vascular remodeling represents a pathological basis for myocardial pathologies,including myocardial hypertrophy and myocardial infarction,which can ultimately lead to heart failure.The molecular mechanism of angiotens...
关键词：angiotensinⅡ myocardial ischemia-reperfusion FOS like-1(FOSL1) myosin heavy chain 9(MYH9) endothelial cell transcription activation 
mTOR pathway:A key player in diabetic nephropathy progression and therapeutic targets
《Genes & Diseases》2025年第2期202-215,共14页Jingxuan Shi Xinze Liu Yuanyuan Jiao Jingwei Tian Jiaqi An Guming Zou Li Zhuo 
supported by the Elite Medical Professionals Project of China-Japan Friendship Hospital (No.ZRJY2021-BJ07);the National High Level Hospital Clinical Research Funding (China) (No.2023-NHLHCRF-PY-07);the National Natural Science Foundation of China (No.81870495).
Diabetic nephropathy is a prevalent complication of diabetes and stands as the pri-mary contributor to end-stage renal disease.The global prevalence of diabetic nephropathy is on the rise,however,due to its intricate ...
关键词：BIBLIOMETRICS Diabetic nephropathy Glomerular endothelial cell Immune cell Mesangial cell mTOR PODOCYTE Renal tubular epithelial cell 
Overexpression of Circ-Astn1 Suppresses Hyperglycemia-Induced Endothelial Cell Damage via the miR-138-5p/SIRT1 Axis
《Current Medical Science》2025年第1期93-103,共11页Hong-bin Yu Li-yun Wang Xiao-ning Yan Xue-yan Wu Jian-long Wu Da-wei Liu Si-yang Liu 
supported by grants from the National Natural Science Foundation of China(No.81770483);Shanghai Tenth Hospital’s improvement plan for NSFC(No.04.03.17.070).
Objective To elucidate the regulatory mechanism of circRNAs in diabetic retinopathy.Methods Next-generation sequencing(NGS)was employed to identify circRNAs that are abnormally expressed in endothe-lial progenitor cel...
关键词：Circ-Astn1 Endothelial cell HYPERGLYCEMIA miR-138-5p SIRT1 
New insights into the endothelial origin of hematopoietic system inspired by“TIF”approaches
《Blood Science》2024年第4期27-35,共9页Siyuan Hou Xia Guo Junjie Du Xiaochen Ding Xiaowei Ning Haizhen Wang Haifeng Chen Bing Liu Yu Lan 
supported by the National Key R&D Program of China(2022YFA110350 and 2020YFA0112400);State Key Laboratory of Experimental Hematology Research Grant(ZK23-04);the National Natural Science Foundation of China(82000111).
Hematopoietic stem progenitor cells(HSPCs)are derived from a specialized subset of endothelial cells named hemogenic endothelial cells(HECs)via a process of endothelial-to-hematopoietic transition during embryogenesis...
关键词：Endothelial-to-hematopoietic transition Genetic lineage tracing Hematopoietic stem progenitor cells Hemogenic endothelial cell Single-cell technology 
Polyethylenimine-modified graphene quantum dots promote endothelial cell proliferation
《Regenerative Biomaterials》2024年第6期50-59,共10页Qirong Xu Chen Li Xiangyan Meng Xinghong Duo Yakai Feng 
supported by the National Natural Science Foundation of China(NSFC 51963018);the‘Chunhui Plan’cooperative scientific research project of the Ministry of Education(Z2015049);the High-level Talents Project of Qinghai University for Nationalities(2019XJG01).
Endothelial cell proliferation plays an important role in angiogenesis and treatment of related diseases.The aim of this study was to evaluate the effect of polyethylenimine(PEI)-modified graphene quantum dots(GQDs)ge...
关键词：graphene quantum dots POLYETHYLENIMINE ZNF580 gene endothelial cell PROLIFERATION 
β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury by activating transcription factor 6 in diabetic nephropathy被引量：2
《World Journal of Diabetes》2024年第12期2322-2337,共16页Jiang Liu Xiao-Yun Song Xiu-Ting Li Mu Yang Fang Wang Ying Han Ying Jiang Yu-Xin Lei Miao Jiang Wen Zhang Dong-Qi Tang 
Supported by Key Research and Development Program of Shandong Province,No.2021CXGC011101;Special Fund for Taishan Scholars Project,No.tsqn202211324;National Natural Science Foundation of China,No.81900669;Natural Science Foundation of Shandong Province,China,No.ZR2018PH007;the Multidisciplinary Innovation Center for Nephrology of the Second Hospital of Shandong University.
BACKGROUND Glomerular endothelial cell(GENC)injury is a characteristic of early-stage diabetic nephropathy(DN),and the investigation of potential therapeutic targets for preventing GENC injury is of clinical importanc...
关键词：Diabetic nephropathy Glomerular endothelial cell β-Arrestin-2 Activating transcription factor 6 Endoplasmic reticulum stress 
Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts
《Bioactive Materials》2024年第11期127-136,共10页Zihao Wang Mengxue Zhou Mengyu Li Jinyu Li Shengmin Zhang Jianglin Wang 
National Key Research and Development Program of China(2022YFA1105100);National Natural Science Foundation of China(32301102;32171323);Fundamental Research Funds for the Central Universities(YCJJ20230215);Science,Technology and Innovation Commission of Shenzhen Municipality(KCXFZ20211020164544008);Sanming Project of Medicine in Shenzhen(SZSM201812055).
Current gold standard for the replacement of small-diameter blood vessel(ID<4 mm)is still to utilize the autologous vessels of patients due to the limitations of small-diameter vascular grafts(SDVG)on weak endothelial...
关键词：Small-diameter vascular grafts Tailored endothelialization Endothelial cell vesicles Click chemistry Vascular remodeling 
Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor:a randomized double-blind trial
《Cancer Biology & Medicine》2024年第10期951-962,共12页Cuicui Zhang Tianqing Chu Qiming Wang Ying Cheng Yongxiang Zhang Ruili Wang Leilei Ma Chaonan Qian Baohui Han Kai Li 
Objective:The possible enhancing effect of anlotinib on programmed death receptor ligand(PD-L1)antibody and the efficacy-predicting power of PD-L1 in micro-conduit endothelium,including lymphatic endothelial cells(LEC...
关键词：PD-L1 lymphatic endothelial cell blood endothelial cell anlotinib progression-free survival 
Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration被引量：1
《Regenerative Biomaterials》2024年第5期49-58,共10页Kui Wang Yongmei Ge Yongshuai Yang Zhenjian Li Jiayi Liu Yizebang Xue Yuanjun Zhang Xiangchao Pang A.H.W.Ngan Bin Tang 
supported by the National Key Research and Development Program of China grants(Project No.2019YFA0906004);the National Foundation of Science,Technology(Project No.11872200);Guangdong Provincial Key Laboratory of Advanced Biomaterials(Project No.2022B1212010003);the Shenzhen Science and Technology Innovation Committee(Project No.KCXFZ20211020174805009,JSGG20200225151916021);Presidential Foundation of Zhujiang Hospital(yzjj2022 ms08).
Diabetes is one of the most prevalent diseases worldwide.The tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction,and this leads to various clinical complications...
关键词：endothelial cell HYPERGLYCEMIA STIFFNESS MIGRATION CDC42 
Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancers
《National Science Review》2024年第9期123-138,共16页Jinhu Li Dongfang Wang Fei Tang Xinnan Ling Wenjie Zhang Zemin Zhang 
supported by the National Key Research and Development Program of China(2023YFF1204700,2023YFF1204704,2023YFF1204702 and 2022YFC2505005);the National Natural Science Foundation of China(81988101,62203019,31991171,91959000,92159305 and 92259205);the Beijing Municipal Science and Technology Commission(Z221100007022002).
Therapeutics targeting tumor endothelial cells(TECs)have been explored for decades,with only suboptimal efficacy achieved,partly due to an insufficient understanding of the TEC heterogeneity across cancer patients.We ...
关键词：tumor endothelial cell pan-cancer single-cell RNA-seq immunotherapy 
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