EPSTEIN-BARR_VIRUS

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An insect cell-derived extracellular vesicle-based gB vaccine elicits robust adaptive immune responses against Epstein-Barr virus
《Science China(Life Sciences)》2025年第3期734-745,共12页Qian Wu Kaiyun Chen Wenhui Xue Guosong Wang Yanbo Yang Shaowei Li Ningshao Xia Yixin Chen 
supported by the National Natural Science Foundation of China(82073756).
Epstein-Barr virus(EBV),the first identified human tumor virus,is implicated in various human malignancies,infectious mononucleosis,and more recently,multiple sclerosis.Prophylactic vaccines have the potential to effe...
关键词：Epstein-Barr virus glycoprotein gB extracellular vesicle humoral immune responses cellular immune responses 
Research landmarks on the 60th anniversary of Epstein-Barr virus
《Science China(Life Sciences)》2025年第2期354-380,共27页Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng 
supported by the National Key Research and Development Program of China(2022YFC3400900);the National Natural Science Foundation of China(82030046,82402614);the Postdoctoral Fellowship Program of CPSF(GZB20230886);the Chinese Postdoctoral Science Foundation(2023M743998,2024T171080);Fundamental Research Funds for the Central Universities(24qnpy278);Shenzhen Medical Research Fund(A2302028)。
Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases...
关键词：EPSTEIN-BARR virus oncovirus IMMUNE response EPIDEMIOLOGY vaccines ANTIBODIES 
Chaetocin reactivates the lytic replication of Epstein-Barr virus from latency via reactive oxygen species
《Science China(Life Sciences)》2017年第1期66-71,共6页Shilun Zhang Juan Yin Jiang Zhong 
Oxidative stress, regarded as a negative effect of free radicals in vivo, takes place when organisms suffer from harmful stimuli. Some viruses can induce the release of reactive oxygen species （ROS） in infected cell...
关键词：Epstein-Barr virus reactive oxygen species chaetocin 
Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas被引量：10
《Science China(Life Sciences)》2014年第3期315-326,共12页ZENG ZhaoYang HUANG HongBin HUANG LiLi SUN MengXi YAN QiJia SONG YaLi WEI Fang BO Hao GONG ZhaoJian ZENG Yong LI Qiao ZHANG WenLing LI XiaYu XIANG Bo LI XiaoLing LI Yong XIONG Wei LI GuiYuan 
supported by the National Natural Science Foundation of China(81172189,81171930,81272298,81272254,91229122,81301757,81372907);the Natural Science Foundation of Hunan Province(14JJ1010);the Fundamental Research Funds for the Central Universities(2011JQ020);the Postdoctoral Science Foundation of Central South University
Epstein-Barr virus(EBV)is associated with nasopharyngeal carcinoma(NPC)tumorigenesis.However,the mechanism(s)connecting EBV infection and NPC remain unclear.Recently,a new class of EBV microRNAs(miRNAs)has been descri...
关键词：Epstein-Barr virus （EBV） microRNA （miRNA） nasopharyngeal carcinoma （NPC） gene regulate network 
Specific cellular immune responses in mice immunized with DNA,adeno-associated virus and adenoviral vaccines of Epstein-Barr virus-LMP2 alone or in combination被引量：10
《Science China(Life Sciences)》2011年第3期263-266,共4页WANG Zhan YANG SongMei ZHOU Ling DU HaiJun MO WuNing ZENG Yi 
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02A229)
Cellular immune responses,particularly those associated with CD3+CD8+ cytotoxic T lymphocytes (CTL),are critical factors in controlling viral infection.Nasopharyngeal carcinoma (NPC) is closely associated with persist...
关键词：EBV-LMP2 DNA vaccine recombinant adenovirus vaccine recombinant adeno-associated virus vaccine combinatorial immunization specific cell-mediated immune responses 
Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers被引量：4
《Science China(Life Sciences)》2005年第4期385-393,共9页SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China 
This work was supported by the StateKey Basic Research Program,Foundational Investigation on Human Carcinogenes is of China(Grant No.G1998051201);National Natural Science Foundat ion for Distinguished Young Scholars of China(Grant No.39525022);National Natural Science Foundation of China(Grant Nos.30300403,30100005&30000087).
In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scan...
关键词：latent membrane protein1  c-Jun  JUN B  heterodimer  cyclin D1  cell cycle. 
Nuclear translocation of EGF receptor regulated by Epstein-Barr virus encoded latent membrane protein 1被引量：2
《Science China(Life Sciences)》2004年第3期258-267,共10页TAO Yongguang1, SONG Xin1, TAN Yunnian1, LIN Xiaofeng2, ZHAO Yan1, ZENG Liang1, TANG Min1, LI Wei1, WU Qiao2 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China 
This work was supported by the National Natural Science Foundation for Distinguished Young Scholar of China(No.3952502);State Key Basic Research Program,Fundamental Investigation on Human Carcinogenesis of China(No.G1998051201);National Natural Science Foundation of China(Grant No.30300407).
Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is considered to be the major oncogenic protein of EBV encoded proteins, and also it has always been the core of the oncogenic mechanism of EBV. Tradit...
关键词：Epstein-Bar virus  LATENT membrane protein 1  EPIDERMAL growth factor receptor  nuclear translocation. 
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