This work was supported by the National Natural Science Foundation of China (NSFC 81672547, 81402110, and 81272820); Science and Technology Support Program of Sichuan Province (2015SZ0142); and the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University.
Even in the era of novel targeted agents, switching to a second-line nonsteroidal antiandrogen (NSAA) is still widely used in treating metastatic castration-resistant prostate cancer (mCRPC), especially in undevel...
The aim of the study was to assess the effects of androgen receptor antagonists on the physical working capacity and activity of some of the key muscle enzymes for the energy supply in rats. Young adult male Wistar ra...
Aim: To determine whether testosterone is involved in morphine withdrawal syndrome (WS). Methods: In order to induce dependency, rats were treated with subcutaneous injection of morphine (days 1-2, 5 mg/kg; days ...
Aim: To identify flutamide regulated genes in the rat ventral prostate. Methods: Total RNA from ventral prostates of control and flutamide treated rats were isolated. Differentially expressed transcripts were identi...
This project was granted by the National Nature Science Foundation of China(No.30100185).
Aim: To explore the effect of androgen receptor (AR) on the expression of the cell cycle-related genes, such as CDKNIA and BTG1, in prostate cancer cell line LNCaP. Methods: After AR antagonist flutamide treatment...