GENE_TRANSFER

作品数：203被引量：509H指数：11
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相关作者：王晶江洪黄从新李庚山李建军更多>>
相关机构：武汉大学中国医学科学院阜外心血管医院大连民族大学青岛大学医学院附属医院更多>>
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An expectation–maximization algorithm for estimating proportions of deletions among bacterial populations with application to study antibiotic resistance gene transfer in Enterococcus faecalis被引量：2
《Marine Life Science & Technology》2023年第1期28-43,共16页Yu Zhang Cong Zhang Wenwen Huo Xinlei Wang Michael Zhang Kelli Palmer Min Chen 
This work was supported by the National Institutes of Health[Grant R15GM131390 to X.W.,Grant R01CA245294 to M.Z.,and Grant R01AI116610 to K.P.]。
The emergence of antibiotic resistance in bacteria limits the availability of antibiotic choices for treatment and infection control,thereby representing a major threat to human health.The de novo mutation of bacteria...
关键词：Bacterial genomes CRISPR-Cas system Antibiotic resistance EM algorithm Proportion estimation 
Phage-mediated horizontal gene transfer and its implications for the human gut microbiome被引量：1
《Gastroenterology Report》2022年第1期78-89,共12页Tatiana Borodovich Andrey N.Shkoporov R.Paul Ross Colin Hill 
financial support from Science Foundation Ireland[grant number SFI/12/RC/2273_P2]and Wellcome Trust under a Wellcome Trust Research Career Development Fellowship[220646/Z/20/Z](A.N.S.);whole,or in part,by the Wellcome Trust[220646/Z/20/Z].
Horizontal gene transfer(HGT)in the microbiome has profound consequences for human health and disease.The spread of antibiotic resistance genes,virulence,and pathogenicity determinants predominantly occurs by way of H...
关键词：gut phageome horizontal gene transfer gene transduction phage-mediated gene transfer 
Horizontal and vertical gene transfer drive sediment antibiotic resistome in an urban lagoon system被引量：5
《Journal of Environmental Sciences》2021年第4期11-23,共13页Hongjie Wang Liyuan Hou Yongqin Liu Keshao Liu Lanping Zhang Fuyi Huang Lin Wang Azhar Rashid Anyi Hu Changping Yu 
supported by the National Natural Science Foundation of China(Nos.31470539 and U1805244);the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(No.2019QZKK0503);the 9th China-Croatia Science and Technology cooperation committee program(No.9–21);supported by the China Scholarship Council(No.201804910668)。
Rapid urbanization has resulted in pervasive occurrence of antibiotic resistance genes(ARGs)in urban aquatic ecosystems.However,limited information is available concerning the ARG profiles and the forces responsible f...
关键词：Urban landscape lagoon Antibiotic resistance genes Heavy metals Horizontal and vertical gene transfer Assembly mechanisms High-throughput quantitative PCR 
Complete genome analysis of bacteriochlorophyll acontaining Roseicitreum antarcticum ZS2-28^(T)reveals its adaptation to Antarctic intertidal environment
《Advances in Polar Science》2021年第1期20-27,共8页ZENG Yinxin YU Yong LI Huirong LUO Wei DING Haitao 
the National Key R&D Program of China(Grant no.2018YFC1406903);the National Natural Science Foundation of China(Grant nos.91851201 and 41476171).
Aerobic anoxygenic phototrophic bacteria(AAPB)are photoheterotrophic prokaryotes able to use both light and dissolved organic matter as energy sources.Roseicitreum antarcticum ZS2-28^(T)was isolated from intertidal se...
关键词：Roseicitreum complete genome ADAPTATION gene transfer strain intertidal sediment ANTARCTIC 
Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine被引量：24
《Genes & Diseases》2017年第2期43-63,共21页Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He 
Research in the authors’laboratories was supported in part by research grants from the National Institutes of Health(AT004418,DE020140 to TCH and RRR);the US Department of Defense(OR130096 to JMW);the Scoliosis Research Society(TCH and MJL);the 973 Program of the Ministry of Science and Technology(MOST)of China(#2011CB707906 to TCH);The reported work was also supported in part by The University of Chicago Cancer Center Support Grant(P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430.
With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become ava...
关键词：ADENOVIRUS Adenoviral vector Cell therapy Gene transfer Gene therapy Oncolytic virus Regenerative medicine Vaccine development 
Non-integrating lentiviral vectors based on the minimal S/MAR sequence retain transgene expression in dividing cells被引量：1
《Science China(Life Sciences)》2016年第10期1024-1033,共10页Zhen Xu Feng Chen Lingling Zhang Jing Lu Peng Xu Guang Liu Xuemin Xie Wenli Mu Yajun Wang Depei Liu 
supported by the Major State Basic Research Development Program of China(2011CB965203)
Safe and efficient gene transfer systems are the basis of gene therapy applications. Non-integrating lentiviral(NIL) vectors are among the most promising candidates for gene transfer tools, because they exhibit high t...
关键词：gene transfer non-integrating lentivirus scaffold/matrix attachment region （S/MAR） episomal vectors 
Inhibition of choroidal neovascularization by lentivirusmediated PEDF gene transfer in rats被引量：8
《International Journal of Ophthalmology(English edition)》2016年第8期1112-1120,共9页Ya-Jie Yu Bin Mo Lu Liu Yan-Kun Yue Chang-Li Yue Wu Liu 
Supported by the National Natural Science Foundation of China(No.81070735)
AIM: To evaluate the effects of lentivirus-mediated pigment epithelium-derived factor (PEDF) gene transfer performed in treatment of rats with established choroidal neovascularization (CNV), and investigates the mecha...
关键词：pigment epithelium-derived factor choroidal neovascularization LENTIVIRUS vascular endothelial growth factor FLK-1 
Human β-NGF gene transferred to cat corneal endothelial cells被引量：2
《International Journal of Ophthalmology(English edition)》2016年第7期937-942,共6页Wen-Juan Luo Min Liu Gui-Qiu Zhao Chuan-Fu Wang Li-Ting Hu Xiang-Ping Liu 
Supported by National Natural Science Foundation(No.30572011);Natural Science Foundation of Shandong Province(No.ZR2010HQ041)
AIM： To transfect the cat corneal endothelial cells （CECs） with recombinant human β-nerve growth factor gene adeno-associated virus （AAV-β-NGF） and to observe the effect of the expressed β-NGF protein on the p...
关键词：nerve growth factor corneal endothelialcell transfect PROLIFERATION 
Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions in both transgenic cells and transgenic mice被引量：1
《Frontiers of Agricultural Science and Engineering》2016年第1期87-96,共10页Xiaoming HU Jing GUO Chunling BAI Zhuying WEI Li GAO Tingmao HU Shorgan BOU Guangpeng LI 
supported by the National Transgenic Breeding Project (2014ZX08007-002)
In the present study, follistatin(FST) gene expression vectors with either a bicistronic gene transfer cassette alone, or a bicistron gene cassette carrying a matrix attachment region(MAR) were constructed and transfe...
关键词：safety of transgenic bicistron gene transfer body transgenic mice muscle development 
Membrane immunoglobulin expressed by retroviral vector gene transfer mimics partial function of the B-cell receptor in vivo被引量：1
《Science China(Life Sciences)》2016年第1期49-58,共10页Jing Lu Feng Chen Zhen Xu Lingling Zhang Peng Xu Depei Liu Chihchuan Liang 
supported by the National Basic Research Program of China(2011CB965203)to Yue Huang
Activation of B-cells is initiated by the ligation of B-cell receptors by its cognate antigen, inducing a series of signal cascades. Understanding the molecular mechanisms of these important events is a crucial goal f...
关键词：BCR membrane immunoglobuUn retroviral vector 
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