GENE_TRANSFER

作品数：204被引量：510H指数：11
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相关作者：王晶江洪黄从新李庚山李建军更多>>
相关机构：武汉大学中国医学科学院阜外心血管医院大连民族大学青岛大学医学院附属医院更多>>
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Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine被引量：24
《Genes & Diseases》2017年第2期43-63,共21页Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He 
Research in the authors’laboratories was supported in part by research grants from the National Institutes of Health(AT004418,DE020140 to TCH and RRR);the US Department of Defense(OR130096 to JMW);the Scoliosis Research Society(TCH and MJL);the 973 Program of the Ministry of Science and Technology(MOST)of China(#2011CB707906 to TCH);The reported work was also supported in part by The University of Chicago Cancer Center Support Grant(P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430.
With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become ava...
关键词：ADENOVIRUS Adenoviral vector Cell therapy Gene transfer Gene therapy Oncolytic virus Regenerative medicine Vaccine development 
Membrane immunoglobulin expressed by retroviral vector gene transfer mimics partial function of the B-cell receptor in vivo被引量：1
《Science China(Life Sciences)》2016年第1期49-58,共10页Jing Lu Feng Chen Zhen Xu Lingling Zhang Peng Xu Depei Liu Chihchuan Liang 
supported by the National Basic Research Program of China(2011CB965203)to Yue Huang
Activation of B-cells is initiated by the ligation of B-cell receptors by its cognate antigen, inducing a series of signal cascades. Understanding the molecular mechanisms of these important events is a crucial goal f...
关键词：BCR membrane immunoglobuUn retroviral vector 
IL-37b gene transfer enhances the therapeutic efficacy of mesenchumal stromal cells in DSS- induced colitis mice被引量：13
《Acta Pharmacologica Sinica》2015年第11期1377-1387,共11页Wei-qiang WANG Kui DONG Lu ZHOU Guo-hui JIAO Cong-zhong ZHU Wen-wen LI Gang YU Wan-tong WU Song CHEN Zhi-na SUN Yu-ming WANG Wen-tian LIU Jie ZHANG Bang-mao WANG Xiao-ming FENG 
Acknowledgements This work was supported by the National Basic Research Pro-gram of China （2013CB966904 and 2015CB964402）, the National Natural Science Foundation of China （81200282, 81273217, 81322007, 81170007, and 81370104）, and the Recruitment Program of Global Youth Experts.
Aim： To investigate whether the transfer of the IL-37b gene, a newly identified inhibitor of both innate and adaptive immunity, could improve the therapeutic efficacy of mesenchumal stromal cells （MSCs） in inflamma...
关键词：inflammatory bowel disease COLITIS dextran sulfate sodium-induced colitis mice mesenchymal stromal cells IL-37b regulatory T cells myeloid-derived suppressor cells inflammatory cytokines 
Optimized human factor IX expression cassettes for hepaticdirected gene therapy of hemophilia B被引量：2
《Frontiers of Medicine》2015年第1期90-99,共10页Ru Zhang Qiang Wang Lin Zhang Saijuan Chen 
Gene therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed gene transfer mediated by adeno-associated viral vectors. Recent clinical trials involving the use ...
关键词：factor IX hemophilia B liver-specific regulatory elements hydrodynamic gene transfer 
Immunological tolerance of human hepatocyte xenograft induced by adenovirus vector-mediated CTLA4Ig gene transfer被引量：2
《Hepatobiliary & Pancreatic Diseases International》2012年第2期148-153,共6页Yao-Kai Chen,Xiao-Cong Liu,Jun-Gang Li,Guo-Dong Liu,Yan Guo,Ling Cheng and Yu-Ming Wang Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China and Department of Digestive Diseases, General Hospital of Chengdu Military Command, Chengdu 610083, China 
supported by a grant from the National Basic Research of China(973 Program 2007CB512903)
BACKGROUND:Systemic administration of CTLA4Ig has been applied in inducing immunological tolerance of hepatocyte implants,but has potential for systemic immune inhibition.This study was designed to induce hepatocyte i...
关键词：CTLA4IG adenovirus vectors hepatocyte transplantation immune tolerance graft rejection 
Production of Transgenic Mice by Type-A Spermatogonia-Mediated Gene Transfer
《Agricultural Sciences in China》2011年第3期431-437,共7页JU Hui-ming BAI Li-jing REN Hong-yan MU Yu-lian YANG Shu-lin LI Kui 
supported by the National Transgenic Breeding Project (2008ZX08010-004);the National Natural Science Foundation of China (30830080);the National 973 Program of China (G2006CB102105,2009CB941604);the National 863 Program of China (20060110Z1039, 2008AA10Z143)
Type-A spermatogonia first appear at between 3-7 d postnatally in mice and are the only immortalized diploid cells that reproduce in adulthood in these animals. In our current study, we explored the feasibility of pro...
关键词：type-A spermatogonia transgenic mice enhanced green fluorescent protein type-A spermatogonia-mediated gene transfer 
Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect被引量：3
《Cellular & Molecular Immunology》2010年第4期296-305,共10页Guili Hu Yang Liu Hong Li Dekuang Zhao Liuqing Yang Jiangen Shen Xuejun Hong Xuetao Cao Qingqing Wang 
supported by grants from the National Natural Science Foundation of China(30328011 and 30872377);the National Basic Research Program of China(2004CB518802);the Science and Technology Department of Zhejiang Province(2008C23044).
Here,we investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT,the tumor-necrosis factor(TNF)superfamily member also known as TNFSF14,in the murine A20 B-cell lymphoma.LIGHT gene modification ...
关键词：ADENOVIRUS B lymphoma gene transfer LIGHT/TNFSF14 
Construction and identification of recombinant lentivirus-mediated gene transfer system for rat transducer of regulated CREB activity 1
《Journal of Nanjing Medical University》2008年第5期304-307,共4页Ying Shi Shigang Cheng Xu Chen Chuanguo Xiao 
National Basic Research Program of China(No.2003CB515304)
Objective： To construct a recombinant lentivirus vector which carries SD rat transducer of regulated CREB activity-1（TORC1） gene and examine its ability to express the TORC 1 gene in vitro. Methods： The coding seq...
关键词：TORC1 lentivirus vector spinal cord injury 
Gene transfer of heat-shock protein 20 protects against ischemia/reperfusion injury in rat hearts被引量：5
《Acta Pharmacologica Sinica》2005年第10期1193-1200,共8页Yan-hui ZHU Tie-min MA Xian WANG 
Project supported by the National Basic Research Program of China (№ G2000056908) awarded to Xian WANG.
Aim： To explore whether overexpression of HSP20 in the myocardium could protect against ischemia/reperfusion injury in rats. Methods： Rat hearts were injected with vector, recombinant adenovirus encoding green fluor...
关键词：reperfusion injury ADENOVIRUS APOPTOSIS myocardial infarction heat-shock proteins 
Protective effect of liposome-mediated glial cell line-derived neurotrophic factor gene transfer in vivo on motoneurons following spinal cord injury in rats被引量：6
《Chinese Journal of Traumatology》2004年第5期275-279,共5页鲁凯伍 陈哲宇 侯铁胜 
ThisworkwassupportedbyNationalNaturalScienceFoundationofChina (30 0 0 0 0 4 8)andtheNationalBasicResearchProgram (G 19990 5 4 0 0 0 )ofChina
Objective: To investigate the effect of liposome-mediated glial cell line-derived neurotrophic factor (GDNF) gene transfer in vivo on spinal cord motoneurons after spinal cord injury (SCI) in adult rats. Methods: Sixt...
关键词：Spinal cord injury Motor neurons LIPOSOME Gene therapy 
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