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作品数:268被引量:567H指数:10
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相关领域:理学医药卫生更多>>
相关作者:李致家王洪伦张珂孙备姜洪池更多>>
相关机构:深圳市烨达科技有限公司中国科学院河海大学哈尔滨医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划福建省自然科学基金更多>>
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Effect of cholesterol metabolism on hepatolithiasis
《World Journal of Gastroenterology》2025年第1期157-162,共6页Lin Zheng Zi-Yu Ye Jun-Ji Ma 
Supported by Hebei Natural Science Foundation,No.H2022206539;Hebei Provincial Government Funded Clinical Talents Training Project,No.ZF2023143.
Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after surgery.Cholesterol metabolism seems to play an impo...
关键词:HEPATOLITHIASIS Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct 
基于不同目标函数的WRF-Hydro模型参数敏感性研究
《中国农村水利水电》2025年第1期61-69,共9页谷黄河 石怀轩 孙敏涛 丁震 顾苏烨 
国家自然科学基金资助项目(42271020);浙江省水利防灾减灾重点实验室开放基金(FZJZSYS21008)。
水文与气象预报相结合可以有效提高洪水预报的精度和延长预见期,陆气耦合模型已成为水文气象学者研究的重点。WRF-Hydro模型作为新一代分布式陆气耦合模型在多尺度洪水预报中具有广阔的应用前景,但由于各物理过程参数化方案复杂,模型计...
关键词:WRF-Hydro模型 Morris法 敏感性分析 多目标函数 洪水预报 
Laboratory-scale studies on the effect of promoters on CO_(2) capture and sequestration via hydrate method:A comprehensive review
《Energy Reviews》2024年第4期18-34,共17页Guangjun Gong Jingru Zhang Ying Teng Qingping Li Mingjun Yang Jia-nan Zheng Bingbing Chen Yongchen Song 
supported by the National Natural Science Foundation of China(52206076,51822603,U19B2005,52306205,52304098);Liao Ning Revitalization Talents Program(XLYC1907096);National Key Research and Development Plan of China(2021YFC2800902);the and the Fundamental Research Funds for the Central Universities of China(DUT21ZD103);Ph.D.Programs Foundation of Liao Ning(2023-BS-060);Study on the marine solidification technology of CO_(2) hydrate(KJGG-2022-12-CCUS-0302);Natural Science Foundation of Guangdong Province(2023A1515012761,2023A1515012316,2022A1515110338);Shenzhen Science and Technology Program(JCYJ20220530113011027,JCYJ20220818095605012).
CO_(2) capture and sequestration via the hydrate method has attracted much attention because of its high sequestration density and energy density.However,the influencing mechanism of the promoters on the formation of ...
关键词:CO_(2)hydrate Promoters CO_(2)capture CO_(2)sequestration 
2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway
《Journal of Traditional Chinese Medicine》2024年第6期1104-1110,共7页WU Shuang LI Qiao ZHU Xieying ZHANG Taoyuan 
Natural Science Basic Research Plan in Shannxi Province of China,the Intervention and Mechanism of Developmentalendotheliallocus-1 Regulating Macrophage Efferocytosis on Airway Inflammation in Chronic Obstructive Pulmonary Disease (No. 2020JQ-543);the Function and Mechanism of New Tumor Suppressor TSC22D2 in Cancer Glycometabolism (No. 2020JQ-927);Fundamental Research Funds for The Central University:the Role of TSC22D2-centered Protein Interaction Map in Cancer Glycometabolism and Cell Growth (No. xzy012019129)。
OBJECTIVE: To investigate the anti-liver cancer effect of 2-hydroxy-3-methyl anthraquinone(HMA) and the specific mechanism based on nicotinamide adenine dinucleotidedependent protein deacetylase sirtuin-1(SIRT1)/cellu...
关键词:2-hydroxy-3-methylanthraquinone carcinoma hepatocellular apoptosis INVASION sirtuin 1 genes p53 
Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia
《Food Science and Human Wellness》2024年第6期3083-3094,共12页Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro 
funded by Consejería de Salud, Junta de Andalucía (PC-0111-2016-0111);PEMP-0085-2020 (cofinanciado con fondos FEDER, convocatoria Resolución de 7 de julio de 2021 de la Secretaría General de Investigación, Desarrollo e Innovación en Salud, que convoca subvenciones para financiar la investigación, el desarrollo y la innovación en Biomedicina y Ciencias de la Salud en Andalucía, para 2021);the Programa PAIDI from the Junta de Andalucía (CTS160);supported by a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/02339);supported by the VI Program of Inner Initiative for Research and Transfer of the University of Seville (VIPPIT2020-II.4);by a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University (DOC_00587/2020);funded by Andalusian Government Ministry of Health (PI-0136-2019);supported by the VI Program of Inner Initiative for Research and Transfer of University of Seville
Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease burden.Statins are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent CVDs.The biochemical mechanism o...
关键词:Functional foods Cholesterol Cardiovascular diseases STATINS 3-Hydroxy-3-methylglutaryl-coenzyme A 
Vision-based docking system for an aromatic-hydrocarbon-inspired reconfigurable robot
《Science China(Technological Sciences)》2024年第6期1798-1816,共19页XING FangYi XU Cheng LIU JinGuo XUE ZhiHui 
supported by the National Key R&D Program of China(Grant No.2018YFB1304600);the CAS Interdisciplinary Innovation Team(Grant No.JCTD-2018-11);the National Natural Science Foundation of China(Grant No.51775541)。
Aromatic hydrocarbons generally refer to compounds containing benzene rings.Many types of isomers can be formed by replacing hydrogen atoms on the benzene ring.In this paper,an aromatic-hydrocarbon-inspired modular ro...
关键词:modular robot reconfiguration aromatic hydrocarbon autonomous docking visual identification 
Mechanistic insight into Cr(Ⅵ)retention by Si-containing ferrihydrite被引量:1
《Journal of Environmental Sciences》2024年第5期217-225,共9页Ying Hu Qiang Xue Honghan Chen Huaming Guo Kenneth C.Carroll Song Wang 
supported by the National Natural Science Foundation of China(Nos.42130509 and 42177061);the National Key Research and Development Program of China(No.2020YFC1808300);Jilin Province Science and Technology Development Projects(No.20190303056SF)。
Hexavalent chromium[Cr(Ⅵ)]causes serious harm to the environment due to its high toxicity,solubility,and mobility.Ferrihydrites(Fh)are the main adsorbent and trapping agent of Cr(Ⅵ)in soils and aquifers,and they usu...
关键词:Hexavalent chromium FERRIHYDRITE Si/Fe ratio Cr(Ⅵ)Adsorption 
miR-1202 regulates BPH-1 cell proliferation,apoptosis,and epithelial-to-mesenchymal transition through targeting HMGCL
《Acta Biochimica et Biophysica Sinica》2024年第5期675-687,共13页Zhenting Wang Xianlai Yin Peng Yang Binghao Gong Haifang Liu 
supported by the grants from the Natural Science Foundation of Hainan Province,China(No.822MS199);the Hainan Provincial Health Commission Project(No.20A200032);the Key Science and Technology Project of Haikou City(No.2022-031);the Finance Science and Technology Project of Hainan Province(No.ZDYF2019112).
Benign prostatic hyperplasia(BPH)is the expansion of the prostategland that results in urinary symptoms.Both the epithelial-to-mesenchymaltransition(EMT)and the Wnt signaling pathway are associated with BPHpathology.I...
关键词:benign prostate hyperplasia(BPH) epithelial-to-mesenchymal transition(EMT) Wnt/β-catenin pathway miR-1202 3-hydroxy-3-methylglutaryl-CoA lyase(HMGCL) 
Recent Advances in Mn,Fe,Co,and Ni-Catalyzed Organic Reactions被引量:2
《CCS Chemistry》2024年第3期537-584,共48页Lu-Jie Li Yuli He Yunhui Yang Jun Guo Zhan Lu Congyang Wang Shaolin Zhu Shou-Fei Zhu 
the National Key R&D Program of China(grant no.2021YFA1500200);the National Natural Science Foundation of China(grant nos.92256301,22221002,22025109,21831008,22101286,and 22271249);the Fundamental Research Funds for the Central Universities(grant nos.226-2022-00224 and 226-2023-00115)for financial support.
This paper reviewed the recent research progress of organic reactions catalyzed by four typical earthabundant and 3d metal catalysts:Mn,Fe,Co,and Ni complexes and mainly focused on the reactions in which these 3d meta...
关键词:Earth-abundant metal catalysts sustainable organic synthesis structure-function relationships organometallic intermediates hydrocarbon transformations 
基于雷达估测降雨及WRF-Hydro模型的典型山洪模拟研究被引量:3
《高原气象》2024年第1期254-263,共10页胡迎春 陈耀登 高玉芳 彭涛 
国家自然科学基金面上项目(42075148)。
受复杂地形与基础气象水文资料缺乏限制,山区小尺度流域的水文预警预报技术较为薄弱,利用高分辨率雷达观测资料驱动分布式水文模型是提高山区小流域洪水预报性能的有效途径之一。本文以位于重庆中部的山区小流域二河流域为研究区域,开...
关键词:WRF-Hydro模型 山区小流域 雷达估测降雨 洪水预报 新安江模型 
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