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I-O: 作品数：862被引量：1399H指数：14; 导出分析报告; 相关领域：理学更多>>; 相关作者：黄楠刘明冷永祥许晓颖唐子龙更多>>; 相关机构：西南交通大学中国科学院南京大学清华大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金河南省科技攻关计划更多>>

Transcriptome and proteome analysis reveals the characteristics of carbon metabolism in the mycelial development of Gomphus purpuraceus: 《Food Science and Human Wellness》2025年第3期941-957,共17页Yangyang Geng Shixin Zhang Yana Liu Likang Qin; the Science and Technology Program of Guizhou Province(2022-General 112);the Major Scientific and Technological Special Project of Guizhou Province(20193006-2);the Regional Fund Project of National Natural Science Foundation of China(32460795)。; Gomphus purpuraceus is an ancient wild edible mushroom.However,the niche and lignocellulose degradation system of G.purpuraceus have remained cryptic.In the current study,transcriptome and proteome sequencing of G.pur...; 关键词：Gomphus purpuraceus Multi-omics CAZymes Lignocellulose decomposition FUMONISINS

Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis: 《Genes & Diseases》2025年第3期382-396,共15页Kai Huang Linyu Yang Yue Ma Lijian Cao Suwen Li Zhenzhen Zhao Jianwu Zhou Shan Wang; supported in part by research grants from the Key Project of the National Key R&D Plan“Research on Prevention and Control of Major Chronic Non-Communicable Diseases”(China);the Ministry of Science and Technology of the People’s Republic of China,and the National Key R&D Program of China(No.2018YFC1313000,2018YFC1313004).; The pathogenesis of neuroblastoma with bone or bone marrow metastasis (NB-BBM)and its complex immune microenvironment remain poorly elucidated, hampering the advancement of effective risk prediction for BBM and limiti...; 关键词：Bone marrow metastasis Bone metastasis IMMUNOTHERAPY Multi-omics NEUROBLASTOMA Transketolase(TKT)

耳聋左慈丸对HEI-OC1细胞氧化应激治疗作用的机制研究: 《中国药科大学学报》2025年第2期188-195,共8页卢国侠顾云双郑亦文彭英阿基业王广基孙建国; 国家重点研发计划“政府间国际科技创新合作”重点专项资助项目(2017YFE0109600)。; 探究耳聋左慈丸对过氧化氢(H_(2)O_(2))致小鼠耳蜗毛细胞株HEI-OC1氧化应激的保护作用并利用细胞代谢组学的手段研究作用机制。实验具体分组如下:对照组、模型组、耳聋左慈丸提取液低、中、高剂量组及阳性对照抗坏血酸组。以HEI-OC1细...; 关键词：耳聋左慈丸小鼠耳蜗毛细胞株HEI-OC1 过氧化氢氧化应激代谢组学

Multi-omics reveals the associations among the fecal metabolome,intestinal bacteria,and serum indicators in patients with hepatocellular carcinoma: 《World Journal of Gastroenterology》2025年第15期109-130,共22页Jing Feng Jun-Ping Wang Jian-Ran Hu Ping Li Pin Lv Hu-Cheng He Xiao-Wei Cheng Zheng Cao Jia-Jing Han Qiang Wang Qian Su Li-Xin Liu; Supported by the Department of Science and Technology of Shanxi Province,No.20210302124369;the Health Commission of Shanxi Province,No.2021116;Shanxi Administration of Traditional Chinese Medicine,No.2024ZYY2C054.; BACKGROUND Hepatocellular carcinoma(HCC),the predominant form of primary liver cancer,is a key contributor to cancer-related deaths globally.However,HCC diagnosis solely based on blood biochemical markers lacks both s...; 关键词：Hepatocellular carcinoma Fecal metabolomics Intestinal bacteria Correlation analysis Non-targeted liquid chromatography-mass spectrometry

刺五加注射液对顺铂诱导的HEI-OC1细胞自噬、凋亡的影响: 《中国老年学杂志》2025年第6期1485-1490,共6页孙婕刘涛杨琨洪丽李瑞华; 湖北科技学院校内培育科研项目资助(2021-22X16)。; 目的探讨刺五加注射液对顺铂诱导的HEI-OC1细胞自噬凋亡的影响及潜在的作用机制。方法取对数生长期的小鼠耳蜗毛细胞HEI-OC1,将细胞分为4组:对照组(正常培养的HEI-OC1细胞)、刺五加组(3μg/ml)、顺铂组(8μg/ml)、顺铂+刺五加组(8μg/m...; 关键词：刺五加注射液顺铂 PTEN诱导假定激酶1/E3泛素连接酶通路自噬细胞凋亡

Traditional Chinese medicine phenomics research on glycolipid metabolism disorder:a review: 《Digital Chinese Medicine》2025年第1期49-58,共10页Xinyi FANG Linxuan MIAO Yanjiao ZHANG Yuxin ZHANG Runyu MIAO Huifang GUAN Jiaxing TIAN; National Natural Science Foundation of China(82474323);High Level Chinese Medical Hospital Promotion Project(HLCMHPP20230CZ40907);China Academy of Chinese Medical Sciences Outstanding Young Scientific and Technological Talents Program(ZZ13-YQ-026).; Traditional Chinese medicine(TCM)has demonstrated unique advantages in the prevention and treatment of chronic diseases such as glycolipid metabolism disorder.However,its widespread application has been hindered by th...; 关键词：Traditional Chinese medicine(TCM) PHENOMICS Multi-omics Glycolipid metabolism disorder Syndrome

LaB_(6)颗粒对等离子堆焊Inconel625合金涂层显微组织和高温抗氧化性能的影响: 《表面技术》2025年第6期98-107,142,共11页李景奎王瑞超潘琳琳邹晓东杨克; 广州市科技计划项目(2024A04J3442);江门市科技计划项目(2023780200040009603);江门市基础与理论科学研究类科技计划项目(2023JC01025,2023JC01006);广东省科技计划项目(2022A0505050052);国家重点研发计划项目(2020YFE0205300);广东省科学院发展专项资金项目(2020GDASYL-20200301001)。; 目的为保证垃圾焚烧炉换热管在高温环境下的正常服役,常在换热管表面制备一层耐高温Inconel625(IN625)合金涂层,然而,随着换热管服役温度的不断增加,有必要提高IN625涂层的高温抗氧化性能,以提升换热管的使用寿命。方法在IN625合金中引...; 关键词：等离子堆焊 INCONEL625合金 LaB_(6) 高温抗氧化性能 La-Ti-O复合氧化物晶粒细化

乙基碘化胺驱动锂氧气电池溶剂相介导及固体电解质界面原位构筑: 《科学通报》2025年第9期1294-1303,共10页李博华孙雯赖静宁张凤玲陈诺陈人杰; 国家重点研发计划(2022YFB2502102);国家自然科学基金(22209011);北京市卓越青年科学家项目(BJJWZYJH01201910007023)资助。; 可溶性氧化还原介质(redox mediator,RM)具有良好的固-液界面接触与电荷传输能力,可以有效介导锂氧气(Li-O_(2))电池绝缘放电产物的形成与分解,加快氧气正极的反应动力学.然而,RM存在“穿梭效应”问题,会导致RM损耗和锂负极腐蚀,影响电...; 关键词：Li-O_(2)电池碘化物穿梭效应添加剂锂负极

基于I-OBE的智能制造工程专业校企协同育人体系研究: 《中国现代教育装备》2025年第5期144-146,共3页殷磊磊许有熊王建红邵立张建华; 南京工程学院高等教育研究课题“基于I-OBE理念的智能制造工程专业产教融合协同育人体系与机制研究”(编号:2023GJYB10);南京工程学院高等教育研究课题“面向应用型人才培养的智能制造工程专业建设与实践教学体系研究”(编号:2021YB33)。; 作为“朝阳产业”的智能制造行业,涉及的技术不断变革、升级,对本科人才培养提出很高要求。为应对智能制造专业人才短缺、质量不足问题,迫切需要开展校企协同育人。通过构建I-OBE“智造”能力导向的“双轨一体一牵引”协同育人体系,以...; 关键词：智能制造产教融合校企协同育人常态化协同育人机制实践教学框架

Analysis of health insurance reform strategies from a risk-sharing perspective based on the Markov model: 《Journal of Southeast University(English Edition)》2025年第1期118-126,共9页XU Pengyu ZHAO Lindu; The National Natural Science Foundation of China(No.72071042)。; China’s healthcare system faces increasing challenges,including surging medical costs,resource allocation imbalances favoring large hospitals,and ineffective referral mechanisms.The lack of a unified strategy integra...; 关键词：equal coverage for the same disease(ECSD) individualized out-of-pocket(I-OOP) health insurance reform risk sharing Markov model

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