云南高校图书馆联盟文献共享服务平台- INSULIN

INSULIN: 作品数：996被引量：2788H指数：21; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张强陈薇贾伟平张大卫平其能更多>>; 相关机构：中国药科大学中国人民解放军总医院北京大学北京协和医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家教育部博士点基金更多>>

Self-assembled nanochaperones enable the disaggregation of amyloid insulin fibrils被引量：1: 《Science China Chemistry》2022年第2期353-362,共10页Hui Wang Ang Li Menglin Yang Yu Zhao Linqi Shi Rujiang Ma; supported by the National Natural Science Foundation of China(51773099,51933006)。; The deposition of highly ordered amyloid fibrils is recognized as a hallmark of amyloidosis diseases such as Alzheimer’s disease and Parkinson’s disease.Disaggregating the amyloid fibrils is considered as one of the...; 关键词：amyloid fibrils INSULIN nanochaperones DISAGGREGATION

Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery被引量：5: 《Science China Chemistry》2019年第5期637-648,共12页Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi; supported by the National Natural Science Foundation of China(51603105,51773099,51390483,91527306,21620102005);the Program for Changjiang Scholars and Innovative Research Team in University(IRT1257); For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insuli...; 关键词：glucose-responsive hydrogel-micelle COMPOSITE phenylboronic acid BASAL and prandial INSULIN delivery controlled release

Studies on the refolding of the reduced-denatured insulin with size exclusion chromatography: 《Science China Chemistry》2005年第z1期55-59,共5页BAI Quan KONG Yu DONG Cuihua GENG Xindu; supported by the National Natural Science Foundation of China(Grant Nos.29675017&39880003);the Foundation of the Young Teacher in the University of Ministry of Education,China(Grant No.DF00308);the Natural Science Foundation in Shaanxi Province(Grant No.2001H02);the Foundation of the Committee of Education in Shaanxi Province(Grant No.99JK101).; The refolding of the reduced-denatured insulin from bovine pancreas was investigated with the size exclusion chromatography(SEC).It was shown that the reduced-denatured insulin originally denatured with 7.0 mol·L-1 g...; 关键词：protein folding size exclusion chromatography reduced-denaturation disulfide bonding INSULIN

Changes of conformation and aggregation state induced by binding of lanthanide ions to insulin: 《Science China Chemistry》2002年第4期349-357,共9页程驿李荣昌王夔; This work was supported by the National Natural Science Foundation of China (Grant No.29890280).; To clarify the mechanism of lanthanide ions (Ln3+) on the across-membrane transport of insulin and subsequent reducing blood glucose, the interactions of Ln3+ with Zn-insulin and Zn-free insulin are investigated by sp...; 关键词：INSULIN LANTHANIDE CONFORMATION aggregation.

Crystal structural studies of destripeptide (B28-B30) insulin: 《Science China Chemistry》2000年第2期178-186,共9页叶军茅毓新桂璐璐常文瑞梁栋材; Single crystals of destripeptide (B28-B30) insulin (DTRI) in three forms were obtained by hanging-drop vapor diffusion method. Form 1 belongs to P21 space group with cell parameters a-4.77 nm, b=6.19 nm, c=6.12 nm, β...; 关键词：destripeptide INSULIN CRYSTAL STRUCTURE HEXAMER RECEPTOR-BINDING potency.

The crystal structure of deshexapeptide(B25-B30)insulin at 0.25 nm resolution被引量：1: 《Science China Chemistry》1995年第9期1094-1100,共7页常文瑞江涛任重万柱礼徐英博梁栋材朱尚权张友尚; the Foundation of Chinese Academy of Sciences;the National Natural Science Foundation of China.; The determination of deshexapeptide(B25-B30)insulin(DHI)was divided into two steps.At the first step,the rough structure model of DHI molecule was determined by using the molecularreplacement method associated with th...; 关键词：deshexapeptide insulin(DHI) molecular close-packing method.

Phase Relationship in Phenol-Insulin Crystal Growth System: 《Science China Chemistry》1994年第8期948-954,共7页梁栋材宋浪舟万柱礼常文瑞; the Foundation of Chinese Academy of Sciences;the National Natural Science Foundation of China; Based on the crystal growth system of rhombohedral 2Zn-insulin,the phase transition ofinsulin crystals has been investigated with the phenol concentration as an independent component.The dia-gram of the phase relation...; 关键词：DIAGRAM of phase relationship phenol-insulin crystal structural STATES of INSULIN HEXAMER

Studies on Long-acting Insulin:Crystal Structure of Arg-B31 Human Insulin at 2.0 Resolution: 《Science China Chemistry》1993年第12期1501-1509,1529-1530,共11页任斌王大成常文瑞张英 R.Obermeier; Project supported by UNIDO Grant (91/048) and the High-Technology Program of China.; The crystal structure of 2 Zn porcine insulin has been refined at 1.2 resolution. The reciprocal space refinement was restrained by the incorporation of extensive chemical observations into the least squares equations...; 关键词：LONG-ACTING INSULIN INSULIN MODIFIER Arg-B31 human INSULIN erystal structure.

SCIENCE IN CHINA (SCIENTIA SINICA) Series B SUBJECT INDEX TO VOLUME 35 (1992): 《Science China Chemistry》1992年第12期1531-1538,共8页; 关键词：Transformation INVERSION Configuration Electron QUARTZ BEAN STEREO INSULIN Correlation Criterion

MOLECULAR CLOSE-PACKING METHOD AND ITS APPLICATION TO CRYSTAL STRUCTURE DETERMINATION OF DESHEXAPEPTIDE (B25--B30) INSULIN: 《Science China Chemistry》1992年第7期783-790,共8页任重梁栋材; Project supported by the Foundation of Chinese Academy of Sciences and the National Natural Science Foundation of China.; Based on the molecule-packing theory, we defined a molecule-packing function express-ing the compatibility of packing among the symmetry-related molecules in a unit cell. Acomputer program imitating the close-packing ...; 关键词：MOLECULAR close-packing METHOD deshexapeptide INSULIN

INSULIN