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Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant: 《Signal Transduction and Targeted Therapy》2022年第11期3973-3975,共3页Ivan Odak Reinhold Förster Berislav Bošnjak; Research in the Förster lab gets supported by the German Center for Infection Research TTU 01.938(grant no 80018019238);German Center for Lung Research(grant 82DZL002B1);Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Excellence Strategy EXC 2155“RESIST”(Project ID39087428);SFB 900/3(Project B1,158989968)and FO334/7-1(all to RF).; Sokal et al.reported recently in Immunity that the SARS-CoV-2 Omicron variant evades recognition by 70%of anti-spike protein antibodies generated by memory B cells(MBCs)from mRNA vaccine-immunized individuals that wer...; 关键词：vaccine ANTIBODIES

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2被引量：7: 《Signal Transduction and Targeted Therapy》2020年第1期733-744,共12页Fei Yu Rong Xiang Xiaoqian Deng Lili Wang Zhengsen Yu Shijun Tian Ruiying Liang Yanbai Li Tianlei Ying Shibo Jiang; supported by grants from the National Natural Science Foundation of China(81974302,82041025,and 81630090);a starting grant from Hebei Agricultural University(YJ201843).; The outbreaks of severe acute respiratory syndrome(SARS)and Coronavirus Disease 2019(COVID-19)caused by SARS-CoV and SARS-CoV-2,respectively,have posed severe threats to global public health and the economy.Treatment ...; 关键词：ANTIBODIES MONOCLONAL PREVENTION

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding被引量：27: 《Cell Research》2017年第1期119-129,共11页Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang XinquanWang; We thank the Cryo-EM and Computing Platforms of the Tsinghua University Branch of the National Center for Protein Sciences （Beijing） for facility support. This work was supported by the National Key Plan for Scientific Research and Development of China （2016YFD0500307 and 2016YFA0501100）, the National Natural Science Foundation of China （81471929, U1405228, 31470721 and 81550001） and the Beijing Advanced Innovation Center for Structural Biology.; The global outbreak of SARS in 2002-2003 was caused by the infection of a new human coronavirus SARS- CoV. The infection of SARS-CoV is mediated mainly through the viral surface glycoproteins, which consist of S1 and ...; 关键词：SARS-COV spike glycoprotein receptor-binding active state CRYO-EM

Structure and receptor-binding properties of an airborne transmissible avian infl uenza A virus hemagglutinin H5(VN1203mut)被引量：11: 《Protein & Cell》2013年第7期502-511,共10页Xishan Lu Yi Shi Wei Zhang Yanfang Zhang Jianxun Qi George F Gao; the National Basic Research Program(973 Program)(No.2011CB504703);the National Natural Sci-ence Foundation of China(Grant No.81290342);.G.F.G.is a leading principal investigator of the NSFC Innovative Research Group(Grant No.81021003)。; Avian infl uenza A virus continues to pose a global threat with occasional H5N1 human infections,which is em-phasized by a recent severe human infection caused by avian-origin H7N9 in China.Luckily these viruses do no...; 关键词：AIRBORNE transmission H5 avian infl uenza STRUCTURE receptor binding

Identification of Dual Receptor-binding Specific Strains of Human H5N1 Viruses in China: 《Biomedical and Environmental Sciences》2012年第1期104-108,共5页ZHOU Jian Fang ZOU Shu Mei LI Zi WANG Min DONG Jie GUO Jun Feng WEI He Jiang WEN Le Ying XU Hong SHU Yue Long; supported by the Ministry of Science and Technology (project No.2007AA02Z417); Objective Both the 2, 6 linkage and its topology on target cells are critical for the recognition by human influenza virus. The binding preference of avian flu virus H5N1 HA to the 2, 3-1inked sialylated glycans is co...; 关键词：Receptor-binding specificity Human H5N2 virus China

Pharmacokinetic-Pharmacodynamic modeling of the analgesic effect of bupredermTM, in mice被引量：1: 《Health》2010年第8期824-831,共8页Min-Hyuk Yun Seung-Wei Jeong Chaul-Min Pai Sun-Ok Kim; Purpose: BupredermTM-Buprenorphine transdermal delivery system (BTDS) was developed for the treatment of post-operative and chronic pains. This study examined the relationship between the plasma concentration of bupre...; 关键词：Pharmacokinetic-Pharmacodynamic Modeling BupredermTM BUPRENORPHINE TRANSDERMAL System SLOW RECEPTOR-BINDING Model

Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers被引量：1: 《World Journal of Gastroenterology》2005年第38期6014-6017,共4页Kawin Leelawat Surang Engprasert Supathip Tujinda Cheepsumon Suthippintawong Munechika Enjoji Manabu Nakashima Takeshi Watanabe Vijittra Leardkamolkarn; Supported by the Thailand Research Fund in the Royal Golden Jubilee Program; AIM： To investigate the expression of receptor-binding cancer antigen expressed on SiSo cells （RCAS1） in metastatic lymph nodes from gastrointestinal cancer. METHODS： Metastatic lymph nodes from gastrointestina ca...; 关键词：RCAS1 Gastrointestinal cancer Lymph node metastasis

Research for SIPI0856 in receptor-binding of the 5-HT: 《Acta Pharmacologica Sinica》2004年第11期1552-1552,共1页Wen-xinDONG Jian-qiLI Xiang-lianNI Feng-huaGU Li-yingHUANG Chao-fengHUANG; AIM: Using the radio ligand-receptor binding assay to study the combined effect of SIPI0856 with 5-HT1 and 5-HT2 receptors,then, to study the bio-effect of SIPI0856 using isolated organ.METHODS: Using [^3H]-5-HT as th...

Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region被引量：3: 《Chinese Science Bulletin》2003年第11期1115-1117,共3页LU Yun CHEN Yinghua; This work was supported by the Anti-SARS Fund of Ministry of Educaton and the National Natural Science Foundation for Outstanding Young Scientist of China(Grant No.30025038).; Coronavirus has been determined to be the cause of the recent outbreak of severe acute respiratory syndrome (SARS). Human coronavirus 229E had been studied well and its receptor-binding domain was restricted to aa417...; 关键词：非典型性肺炎冠状病毒鼠类肝炎病毒 SARS 蛋白质抗过滤性病源体药物疫苗异体同形

Crystal structural studies of destripeptide (B28-B30) insulin: 《Science China Chemistry》2000年第2期178-186,共9页叶军茅毓新桂璐璐常文瑞梁栋材; Single crystals of destripeptide (B28-B30) insulin (DTRI) in three forms were obtained by hanging-drop vapor diffusion method. Form 1 belongs to P21 space group with cell parameters a-4.77 nm, b=6.19 nm, c=6.12 nm, β...; 关键词：destripeptide INSULIN CRYSTAL STRUCTURE HEXAMER RECEPTOR-BINDING potency.

RECEPTOR-BINDING