supported by the National Key Research and Development Program of China(2019YFA0508900);the National Natural Science Foundation of China(32330021,31991162,32200477);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37010100)。
Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin str...
National Natural Science Foundation of China(81972341,81900158,81772663,81874078,82072896);Shanghai Municipal Science and Technology Commission(201409002700,19JC1413500,21XD1403100);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20161310);Pudong New Area Science&Technology Development Fund(PKJ2018-Y47).
Tumor relapse is the major cause of treatment failure in childhood acute lymphoblastic leukemia(ALL),yet the underlying mechanisms are still elusive.Here,we demonstrate that phosphoribosyl pyrophosphate synthetase 2(P...
supported by the National Natural Science Foundation of China (Grant No. 12090054)。
Cryo-electron microscopy(cryo-EM) provides a powerful tool to resolve the structure of biological macromolecules in natural state. One advantage of cryo-EM technology is that different conformation states of a protein...
In multiple sclerosis(MS),human endogenous retrovirus W family(HERV-W)envelope protein,pHERV-W ENV,limits remyelination and induces microglia-mediated neurodegeneration.To better understand its role,we examined the so...
supported by the National Basic Research Program of China(No.2016YFA0200700);the National Natural Science Foundation of China(Nos.21773041 and 21972031);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)。
Here,the selective adsorption behaviors of guest molecule COR in two hexamer host grids were investigated by means of scanning tunnelling microscope(STM).The assembled structures of small functional organic molecules ...
supported by the Ministry of Science and Technology (Nos.2018YFA0306003,2017YFA0205003);National Natural Science Foundation of China (No.21972002);supported by High-performance Computing Platform of Peking University
The self-assembly of L-tryptophan on Cu(111) is investigated by an ultrahigh vacuum scanning tunneling microscope(STM) at 4.4 K.When deposited onto the substrate at around 120 K with a coverage of 0.1 monolayer,molecu...
the financial support from the National Natural Science Foundation of China(21171135);Hubei Provincial Science & Technology Department(2011BFA020);Hubei Independent Innovation Base(HBIR07)
A polymer, [NiL(bipy)·2H2O]n(1, bipy = 4,4ˊ-bipyridine), has been acquired by the reaction of Ni(OAc)2·4H2O with N,Nˊ-bis(2-hydroxyl-5-fluorobenzyl)-2-hydrxylpropane dii- mine in the presence of 4,4ˊ-bipy...
The murine peptidylarginine deiminase (PAD) has five isoforms encoded by different genes and participates in a variety of cellular functions through the citrullination of target proteins. The crystal structure of huma...
Supported by the National Natural Science Foundation of China under Grant No 10032040, and the CNPC Innovation Fund.
From discussion of the structure of liquid water, we deduce that water under ambient condition is mainly composed of ice Ih-like molecular dusters and clathrate-like molecular clusters. The water molecular dusters rem...
Single crystals of destripeptide (B28-B30) insulin (DTRI) in three forms were obtained by hanging-drop vapor diffusion method. Form 1 belongs to P21 space group with cell parameters a-4.77 nm, b=6.19 nm, c=6.12 nm, β...