Objective To investigate the effect and mechanism of forkhead box K1 (FOXK1) in acute kidney injury(AKI),and to provide new ideas and targets for preventing and treating AKI.Methods Three models of AKI were establishe...
Objective To investigate the role of immunoglobulinlike domain-containing receptor 2(Ildr2)in renal fibrosis induced by ischemia-reperfusion.Methods Ildr2 knockout mice(KO group)were constructed using CRISPR/Cas9 tech...
Supported by Dutch Gastroenterology and Hepatology Society(MLDS grant WO10-57 to Dejong CHC and Lenaerts K);Career Development Grant CDG(to Derikx JPM);The Netherlands Organisation for Scientific Research(Rubicon grant 825.13.012 to Grootjans J)
Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the patho...
Aim Shengmai injection (SMI) , a Chinese patent medicine deprived from an ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in cl...
supported by Science and Technology Planning Project of Guangdong Province (No.2010B031600017)
Background Heat shock protein 70 (HSP70) has been shown to exert a protective effect in hearts subjected to ischemia-reperfusion and alleviate adverse effects of myocardial ischemia-reperfusion injury (MIRI). Howe...
Supported by University of Tehran,Vice chancellor forresearch and technology
AIM: To investigate the structural and biochemical changes in the early stage of reperfusion in the rat livers exposed to lobar ischemia-reperfusion (IR). METHODS: The median and left lobes of the liver were subje...
Supported by the National Natural Science Foundation of China,No. 30400172, 30230370the National Basic Science and Development programme (973 programme, 2005 CB 522603)
AIM: To detect the effect of acid fibroblast growth factor (aFGF) on P53 and P21WAF-1 expression in rat intestine after ischemia-reperfusion (I-R) injury in order to explore the protective mechanisms of aFGF. MET...
AIM: To study the effects of dl-praeruptorin A (Pd-Ia) on nucleus factor-κB (NF-κB) activativity and tumor necrosis factor-α(TNF-α)expression in ischemia-reperfusion (I/R) myocardium. METHODS: Langendorff's isolat...