LUNG_CANCER

作品数：1119被引量：2734H指数：22
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A nanoplatform self-assembled by coordination delivers siRNA for lung cancer therapy被引量：2
《Rare Metals》2023年第5期1483-1493,共11页Zi-Yao Wang Jie Mei Dong-Qi Ni Sheng-Mei Li Jin-Min Ye Shi-Lin Li Ya-Ling Wang Ying Liu 
financially supported by the Program for International S and T Cooperation Projects of the Ministry of Science and Technology of China (No.2018YFE0117200);the National Natural Science Foundation of China (No.31971318);the Special Project for Research and Development in Key Areas of Guangdong Province (No.2020B0101020001);the StrategicPriority Research Program of Chinese Academy of Sciences (No.XDB36000000)。
The high incidence and mortality of lung cancer have present threaten in front of people all over the world.Researches in clinical trials find that mutations of some genes influence progress of lung cancer directly or...
关键词：Lung cancer SIRNA COORDINATION NANOPARTICLES Drug delivery 
Placebo effect in the treatment of non-small cell lung cancer:a meta-analysis被引量：1
《Journal of Bio-X Research》2022年第3期132-140,共9页Siyuan Ren Mengyao Ma Chuan He Yuhui Deng Xiaoyun Chen Yonglin Liu Yangyang Jin Yansong Liu Lei Cai Lin He 
Natural Science Foundation of Shanghai(No.19ZR1427700);Ministry of Science and Technology of China(No.2017YFC1001302);Shanghai Key Laboratory of Psychotic Disorders(13dz2260500)in Shanghai Mental Health Center,China(No.19-K02).
Objective:The majority of non-small cell lung cancer(NSCLC)cases remain undiagnosed until advanced stages of the disease.Accumulating studies have highlighted the utility of palliative care as an effective treatment o...
关键词：lung cancer META-ANALYSIS NSCLC palliative care placebo effect 
Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages
《Cancer Biology & Medicine》2022年第7期1047-1060,共14页Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue Yanlei Liu Jesús M.de la Fuente Daxiang Cui 
supported by the National Key Basic Research Program(973 Project)(Grant Nos.2015CB931802 and 2017FYA0205301);the Special Fund for Science and Technology Innovation of Shanghai Jiao Tong University(Grant Nos.YG2017MS70,YG2015MS62,and AF0300179);the Shanghai Municipal Bureau of Economy and Information Technology(Grant No.XC-ZXSJ-02-2016-05);the National Natural Scientific Foundation of China(Grant Nos.8202010801,81921002,81225010,81028009,and 31170961);the 863 Project of China(Grant No.2014AA020700);and the Shanghai Science and Technology Fund(Grant No.13NM1401500)。
Objective:Although great progress has been made in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA therapeutics.Methods:We developed an up-conversion n...
关键词：Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery 
QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer被引量：6
《Journal of Molecular Cell Biology》2021年第5期347-360,共14页Jin-Zhu Wang Xing Fu Zhaoyuan Fang Hui Liu Feng-Yang Zong Hong Zhu Yan-Fei Yu Xiao-Ying Zhang Shen-Fei Wang Ying Huang jingyi Hui 
This work was supported by the National Natural Science Foundation of China(31661143035,31770881,and 32071288);the National Basic Research Program of China(2017YFA0504400)to J.H.
Accumulating evidence indicates that the alternative splicing program undergoes extensive changes during cancer develop-ment and progression.The RNA-binding protein QKI-5 is frequently downregulated and exhibits anti-...
关键词：ADD3t alternative splicing RNA-binding protein QKI lung cancer 
Lung stem cells in regeneration and tumorigenesis
《Journal of Genetics and Genomics》2021年第4期268-276,共9页Yuting Chen Yun Xue Yujuan Jin Hongbin Ji 
supported by the National Natural Science Foundation of China(81402371 to Y.J.,82030083 to H.J.,91731314 H.J.,81872312 to H.J.,82011540007 to H.J.,31621003 to H.J.);the National Basic Research Program of China(2017YFA0505501 to H.J.;2020YFA0803300 to H.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19020201 to H.J.);the Basic Frontier Scientific Research Program of Chinese Academy of Science(ZDBS-LY-SM006 to H.J.);the International Cooperation Project of Chinese Academy of Sciences(153D31KYSB20190035 to H.J.)。
Adult lung is a highly quiescent organ,with extremely low cell turnover frequency.However,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various injuries.Lun...
关键词：Lung stem cells Lung cancer REGENERATION TUMORIGENESIS Pathological transition 
Radiomics model for distinguishing tuberculosis and lung cancer on computed tomography scans被引量：5
《World Journal of Clinical Cases》2020年第21期5203-5212,共10页E-Nuo Cui Tao Yu Sheng-Jie Shang Xiao-Yu Wang Yi-Lin Jin Yue Dong Hai Zhao Ya-Hong Luo Xi-Ran Jiang 
Supported by Youth Science and Technology Innovation Leader Support Project,No.RC170497;Shenyang Municipal Science and Technology Project,No.F16-206-9-23;Natural Science Foundation of Liaoning Province of China,No.201602450;National Key R&D Program of Ministry of Science and Technology of China,No.2016YFC1303002;National Natural Science Foundation of China,No.81872363;Major Technology Plan Project of Shenyang,No.17-230-9-07;Supporting Fund for Big data in Health Care,No.HMB201903101;2018 Key Research and Guidance Project of Liaoning Province,No.2018225038.
BACKGROUND Pulmonary tuberculosis(TB)and lung cancer(LC)are common diseases with a high incidence and similar symptoms,which may be misdiagnosed by radiologists,thus delaying the best treatment opportunity for patient...
关键词：Pulmonary tuberculosis Lung cancer Radiomics Computed tomography Computer–aided diagnosis NOMOGRAM 
Pathological transition as the arising mechanism for drug resistance in lung cancer被引量：11
《Cancer Communications》2019年第1期469-481,共13页Yueqing Chen Waiying Yvonne Tang Xinyuan Tong Hongbin Ji 
This work was supported by the National Basic Research Program of China(Grant No.2017YFA0505501);Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB19020201);National Natural Science Foundation of China(Grant Nos.81430066,91731314,31621003,81872312,81871875,81802279).
Despite the tremendous efforts for improving therapeutics of lung cancer patients,its prognosis remains disappoint-ing.This can be largely attributed to the lack of comprehensive understanding of drug resistance leadi...
关键词：Lung cancer Drug resistance Pathological transition 
5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer被引量：7
《Genomics, Proteomics & Bioinformatics》2018年第3期187-199,共13页Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian 
supported by grants from the Ministry of Science and Technology of China (Grant No. 2016YFC0900300);National Natural Science Foundation of China (Grant Nos. 31670895, U1504831, 31430022, 31670824, 31400672, and 81703598);Major Science and Technology Project of Henan Province (Grant No. 161100310100);Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB14030300);Foundation for University Young Key Teacher of Henan Province (Grant No. 2015GGJS-162);Science and Technology Project of Henan Province (Grant No.162102310199), China
Non-small-cell lung cancer （NSCLC）, the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymetbylcy...
关键词：5-Hydroxymethylcytosine Lung cancer Cell-free DNA BIOMARKER 5hmC-Seal 
Chromatin remodeling factor lymphoid.specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression被引量：6
《Chinese Journal of Cancer》2017年第12期669-671,共3页Yiqun Jiang Yuchen He Shuang Liu Yongguang Tao 
supported by the National Natural Science Foundation of China[81372427 and 81672787(Y.Tao);81271763 and 81672991(S.Liu)];the National Basic Research Program of China[2015CB553903(Y.Tao)]
Ferroptosis, a novel mode of non-apoptotic cell death,involves a metabolic dysfunction that results in the production of iron-dependent reactive oxygen species (ROS),an iron carrier protein (transferrin), intracellula...
关键词：Ferroptosis  a novel mode of non-apoptotic cell DEATH 
Adjuvant Effects of Fermented Red Ginseng Extract on Advanced Non-Small Cell Lung Cancer Patients Treated with Chemotherapy被引量：8
《Chinese Journal of Integrative Medicine》2017年第5期331-337,共7页JIANG Shu-long LIU Hong-jie LIU Zhao-chun LIU Ning LIU Rui Young-Reep Kang Joong-Gu Ji ZHANG Chao HUA Bao-jin Shin-Jyung Kang 
Supported in part by a grant from the Major Projects for"Creation of Major New Drugs"of the Ministry of Science and Technology of China(No.2010ZX09102-216);the Korea Joongbu University Research Fund
Objective： To investigate the adjuvant therapeutic effects of fermented red ginseng（FRG） extract on non-small cell lung cancer（NSCLC） patients treated with chemotherapy. Methods： A total of 60 patients with adva...
关键词：lung cancer Korean red ginseng fermented red ginseng extract chemotoxicity tumor adjuvant therapy Chinese medicine 
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