LUPEOL

作品数：15被引量：45H指数：3
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相关领域：医药卫生更多>>
相关作者：刘芬朱永明何艳李云森刘海燕更多>>
相关机构：苏州大学贵阳中医学院中国科学院武汉大学更多>>
相关期刊：《Journal of Coastal Life Medicine》《Systems Microbiology and Biomanufacturing》《Acta Pharmacologica Sinica》《Advances in Biological Chemistry》更多>>
相关基金：国家自然科学基金湖北省自然科学基金广东省科技计划工业攻关项目博士科研启动基金更多>>
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Chemical Constituents from Ethyl Acetate Extract of Graptophyllum glandulosum Turrill and New Semi-Synthetic Derivative with Antimicrobial Activities
《Advances in Biological Chemistry》2025年第1期18-30,共13页Cyrille Ngoufack Tagousop Donald Léonel Feugap Tsamo Arnaud Joseph Nguetse Dongmo Dominique Harakat Laurence Voutquenne-Nazabadioko Jean-de-Dieu Tamokou David Ngnokam 
From the ethyl acetate extract of the medicinal plant Graptophyllum glandulosum Turrill, five known compounds: Lupeol (1), Oleanolic acid (2), Chrysoeriol (3), N-methyl-isonicotinamide (4) and β-sitosterol 3-O-β-D-g...
关键词：Graptophyllum glandulosum Turrill LUPEOL Oxidation Reaction Antimicrobial Activities 
Current advances in the biotechnological synthesis of betulinic acid:new findings and practical applications被引量：1
《Systems Microbiology and Biomanufacturing》2023年第2期179-192,共14页Yawen Wu Zhenbo Yuan Yijian Rao 
supported by the National Key R&D Program of China(2018YFA0901700);the Natural Science Foundation of Jiangsu Province(BK20202002);the Postgraduate Research and Practice Innovation Program of Jiangsu Province(KYCX18_1789).
Betulinic acid(BA),a penta-cyclic triterpenoid found as a ubiquitous secondary metabolite throughout the plant kingdom,has aroused tremendous interests due to its different pharmacological properties,which lead to lar...
关键词：Betulinic acid BIOSYNTHESIS Lupeol synthase CYP716A subfamily 
Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways被引量：12
《Acta Pharmacologica Sinica》2022年第8期1989-2002,共14页Dan Li Ying-ying Guo Xian-feng Cen Hong-liang Qiu Si Chen Xiao-feng Zeng Qian Zeng Man Xu Qi-zhu Tang 
supported by the Key Project from the National Natural Science Foundation(82000229);National Key R&D Program of China(2018YFC1311300);Development Center for Medical Science and Technology National Health and Family Planning Commission of the People’s Republic of China(The prevention and control project of the cardiovascular disease,2016ZX-008-01);Science and Technology Planning Projects of Wuhan(2018061005132295).
Inflammation and apoptosis are main pathological processes that lead to the development of cardiac hypertrophy.Lupeol,a natural triterpenoid,has shown anti-inflammatory and anti-apoptotic activities as well as potenti...
关键词：LUPEOL cardiac hypertrophy pressure overload INFLAMMATION TLR4 PI3K NF-κB 
In silico prediction of phytoconstituents from Ehretia laevis targeting TNF-αin arthritis被引量：2
《Digital Chinese Medicine》2021年第3期180-190,共11页Subhash R.Yende Sapan K.Shah Sumit K.Arora Keshav S.Moharir Govind K.Lohiya 
Objective Rheumatoid arthritis(RA)is an autoimmune disease involving the synovial lining of the major joints.Current therapies have noteworthy side effects.Our study involved in silico evaluation of Ehretia laevis(E.l...
关键词：Rheumatoid arthritis Ehretia laevis In silico Molecular docking Pharmacokinetics Tumor necrosis factor-α(TNF-α) LUPEOL α-Amyrin 
Response surface methodology-based optimization of ultrasound-assisted extraction of β-sitosterol and lupeol from Astragalus atropilosus(roots) and validation by HPTLC method被引量：2
《Asian Pacific Journal of Tropical Biomedicine》2020年第6期281-292,共12页Perwez Alam Nasir A.Siddiqui Ali S.Alqahtani Anzarul Haque Omer A.Basudan Saleh I.Alqasoumi M.U.Khan 
the Researchers Supporting Project Number(RSP-2019/132),King Saud University,Riyadh,Kingdom of Saudi Arabia.
Objective:To optimize the ultrasonication method for efficient extraction ofβ-sitosterol and lupeol from the roots of Astragalus atropilosus using Box-Behnken design of response surface methodology(RSM),and its valid...
关键词：Β-SITOSTEROL LUPEOL Box-Behnken design ASTRAGALUS High performance thin layer CHROMATOGRAPHY 
Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease被引量：1
《Asian Pacific Journal of Tropical Medicine》2017年第12期1117-1122,共6页Prashamsa Koirala Su Hui Seong Hyun Ah Jung Jae Sue Choi 
Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Education(2012R1A6A1028677)
Objective: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against b-site amyloid precursor protein cleaving enzyme 1(BACE1), which serve as a rate limiting step in amyloid beta(A...
关键词：Pueraria lobata BACE1 LUPEOL Lupenone Molecular docking Kinetics 
羽扇豆醇Lupeol通过Wnt／β-连环蛋白信号通路抑制肝癌细胞增殖的机制被引量：2
《中华实验外科杂志》2015年第8期1872-1875,共4页张玲莉 邱振鹏 涂毅 彭燕 
湖北省自然科学基金资助项目（2013CFB239）
目的探讨羽扇豆醇Lupeol通过Wnt／β-连环蛋白（母一catenin）信号通路抑制肝癌细胞增殖的作用机制。方法采用细胞计数试剂盒（CCK-8）法及碘化丙锭（PI）单染法检测Lupeol对肝癌细胞的生长抑制作用及细胞周期的影响；以荧光素酶TOPflas...
关键词：羽扇豆醇 HEPG2细胞株 WNT信号通路 抗增殖 
Phytochemical investigation and simultaneous estimation of bioactive lupeol and stigmasterol in Abutilon indicum by validated HPTLC method
《Journal of Coastal Life Medicine》2014年第5期394-401,共8页Md.Sarfaraj Hussain Sheeba Fareed Mohammad Ali Md.Sarfaraz Alam Md.Akhlakquer Rahman A.K.Srivastava 
Objective:To perform a simultaneous quantitative estimation of two biologically active triterpenoid compounds lupeol and a steroid compound,stigmasterol,in Abutilon indicum(A.indicum)using high-performance thin-layer ...
关键词：Abutilon indicum(Linn)Sweet HPTLC-UV_(530) LUPEOL Stigmasterol Validation 
Lupeol对肝癌SMMC-7721细胞增殖及凋亡的影响
《岭南现代临床外科》2014年第6期624-627,共4页李悦 薛平 曹良启 卢海武 郑强 温子龙 张大伟 
广东省科技计划项目(编号:2012B061700047);广州医科大学博士启动项目(编号:2012C08)
目的探讨羽扁豆醇(lupeol)对人肝癌SMMC-7721细胞生长和凋亡的作用及机制。方法采用MTT法检测lupeol对肝癌细胞SMMC-7721和正常肝细胞L-02的增殖抑制作用,流式细胞法检测细胞凋亡情况,Western blot检测TRAIL受体及抗凋亡蛋白表达变化,...
关键词：羽扁豆醇 肝癌细胞 凋亡 c-FLIPL 
Lupeol:An antioxidant triterpene in Ficus pseudopalma Blanco(Moraceae)
《Asian Pacific Journal of Tropical Biomedicine》2014年第2期109-118,共10页Librado A Santiago Anna Beatriz R.Mayor 
Supported by Grants-in-aid of the Philippine Council for Health Research and Development,Department of Science and Technology(Grant no.120023)
Objective:To assess the antioxidant activity of Ficus pseudopalma Blanco(Moraceae)(F.pseudopalma) and characterize the active components present in it.Methods:Column chromatography of crude ethanol leaf extract of F.p...
关键词：ANTIOXIDANT Oxidative stress Free radical SCAVENGING Reducing power Phenolic acids FICUS pseudopalma Blanco 
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