MACHINERY

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  • 期刊=Signal Transduction and Targeted Therapyx
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Commanding the Commander:structure of a key protein machinery in endosomal trafficking
《Signal Transduction and Targeted Therapy》2023年第9期3877-3879,共3页Xin Yong Chunzhuang Zhou Daniel D.Billadeau Da Jia 
This work was supported by Natural Science Foundation of China(NSFC#32200559,#92254302);National Key Research and Development Program of China(2022YFA1105200);National Science Fund for Distinguished Young Scholars(#32125012);National Institutes of Health grant DK107733 to D.D.B.
In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microsc...
关键词：COMMANDER COMMAND SORTING 
RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle
《Signal Transduction and Targeted Therapy》2023年第2期321-322,共2页Xiaocui Wei Junxia Li Yang Li 
This work was supported by the National Natural Science Foundation of China(32192423).
Two emerging studies published in Nature back to back reported the cryo-electron microscopy(cryo-EM)structures of Dicer complexes in the double-stranded RNA(dsRNA)-processing cycle,providing detailed mechanistic insig...
关键词：INSIGHT COMPLEXES CYCLE 
SARS-CoV-2 N protein potentiates host NPM1-snoRNA translation machinery to enhance viral replication
《Signal Transduction and Targeted Therapy》2022年第11期4003-4006,共4页Hui Wang Danrong Shi Penglei Jiang Zebin Yu Yingli Han Zhaoru Zhang Peihui Wang He Huang Hangping Yao Pengxu Qian 
National Key Research and Development Program of China,Stem Cell and Translation Research[2018YFA0109300 to P.Q.];National Natural Science Foundation of China[82222003,81870080,91949115,82161138028 to P.Q.;31900815 to H.W.];Natural Science Foundation of Zhejiang Province[LR19H080001 to P.Q.];Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang[2020R01006 to P.Q.];Zhejiang Provincial Key Research and Development Program[2021C03043 to H.Y.].We are grateful to W.P.H.(Shandong University)for providing original SARS-CoV-2 protein expressing plasmids.
Dear Editor,COVID-19(Coronavirus Disease 2019)is causing an unprecedented public health crisis.Protein translation is crucial for virus lifecycle.Nucleocapsid(N)protein is among the most abundant SARS-CoV-2 proteins a...
关键词：TRANSLATION MACHINERY among 
ESCRT machinery:role of membrane repair mechanisms in escaping cell death
《Signal Transduction and Targeted Therapy》2022年第8期2655-2657,共3页Lisa Gregor Sophia Stock Sebastian Kobold 
supported by the Else Kröner-Fresenius Clinician Scientist Program Cancer Immunotherapy,the Munich Clinician Scientist Program(MCSP);the DKTK School of Oncology.This work was supported by the Marie Sklodowska-Curie Program Training Network for Optimizing Adoptive T Cell Therapy of Cancer funded by the H2020 Program of the European Union(Grant 955575,to S.K.);the Hector Foundation(to S.K.);the International Doctoral Program i-Target:Immunotargeting of Cancer funded by the Elite Network of Bavaria(to S.K.);Melanoma Research Alliance Grants 409510(to S.K.);the Else Kröner-Fresenius-Stiftung(2021_EKFK_01,to S.K.);the German Cancer Aid(to S.K.);the Ernst-Jung-Stiftung(to S.K.);the LMU Munich’s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative(to S.K.);the Bundesministerium für Bildung und Forschung(to S.K.);the Go-Bio Initiative(to S.K.);the m4 award of the Bavarian Ministry for Economical Affairs(to S.K.);the European Research Council Grant 756017,ARMOR-T(to S.K.);the German Research Foundation(DFG)(to S.K.);the SFB-TRR 338/12021-452881907(to S.K.);the Fritz-Bender Foundation(to S.K.);the Deutsche José-Carreras Leukämie-Stiftung(to S.K.).
A recent research article published in Science by Ritter et al.reported that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming ...
关键词：al. CYTOTOXICITY DEATH 
Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery
《Signal Transduction and Targeted Therapy》2021年第8期2331-2333,共3页Lili Cai Lihui Li Xihui Chen Lijun Jia 
This work was supported by the following funds:The Chinese Minister of Science and Technology grant(2016YFA0501800);National Natural Science Foundation of China(Grants 81625018,81802743,and 81820108022);Program of Shanghai Academic/Technology Research Leader(18XD1403800);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056);National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001).
Dear Editor,S phase kinase-associated protein 2(SKP2),a substrate recognition component of the SCFSKP2 ubiquitin ligase complex,plays an oncogenic role in tumorigenesis by targeting a variety of tumor suppressors(e.g....
关键词：SKP2 SUPPRESSOR shock 
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