MAMMALIAN_CELLS

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Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells
《Cell Research》2024年第1期31-46,共16页Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie 
supported by the HRHI program 202209009 of Westlake Laboratory of Life Sciences and Biomedicine,Westlake Education Foundation,Tencent Foundation,the National Natural Science Foundation of China(32071429);the Ministry of Science and Technology of China(2020YFA0909200);supported by China Postdoctoral Science Foundation(2020M671805,2020T130107ZX to J.S.).Some drawings in this manuscript were kindly provided by Scidraw.io.
Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a syntheti...
关键词：TRANSLATIONAL RENDER alone 
ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells被引量：3
《Cell Research》2020年第9期732-744,共13页Xiaojing Liu Tingting Liu Yafang Shang Pengfei Dai Wubing Zhang Brian J.Lee Min Huang Dingpeng Yang Qiu Wu Liu Daisy Liu Xiaoqi Zheng Bo O.Zhou Junchao Dong Leng-Siew Yeap Jiazhi Hu Tengfei Xiao Shan Zha Rafael Casellas X.Shirley Liu Fei-Long Meng 
supported by National Key R&D Program of China(2017YFA0506700,2017YFC0908500);Strategic Priority Research Program of Chinese Academy of Sciences(XDB19030000);National Natural Science Foundation of China(81622022,31670929,31800766);X.L.is supported by China Postdoctoral Science Foundation Grants(2018M632180,2019T120363);GTP center is supported by a Shanghai Municipal Commission for Science and Technology Grant(17411954900).
Programmed DNA recombination in mammalian cells occurs predominantly in a directional manner.While random DNA breaks are typically repaired both by deletion and by inversion at approximately equal proportions,V(D)J an...
关键词：joining typically REPAIR 
Overview of macroautophagy regulation in mammalian cells被引量：70
《Cell Research》2010年第7期748-762,共15页Maryam Mehrpour 
Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis. In this review, we consider macroautophagy in the light...
关键词：AUTOPHAGY cell signaling intracellular trafficking LYSOSOMES PROTEOLYSIS 
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells被引量：18
《Cell Research》2008年第1期27-47,共21页Muralidhar L Hegde Tapas K Hazra Sankar Mitra 
Base excision repair （BER） is an evolutionarily conserved process for maintaining genomic integrity by eliminating several dozen damaged （oxidized or aikylated） or inappropriate bases that are generated endogenous...
关键词：DNA glycosylases AP-endonuclease covalent modification BER subpathways repair complex BER interactome 
Transcription-coupled nucleotide excision repair in mammalian cells： molecular mechanisms and biological effects被引量：11
《Cell Research》2008年第1期73-84,共12页Mafia Fousteri Leon HF Mullenders 
The encounter of elongating RNA polymerase Ⅱ （RNAPⅡo） with DNA lesions has severe consequences for the cell as this event provides a strong signal for P53-dependent apoptosis and cell cycle arrest. To counteract p...
关键词：DNA damage TRANSCRIPTION nucleotide excision repair transcription coupled repair Cockayne syndrome chromatin remodelling 
MAPK signal pathways in the regulation of cell proliferation in mammalian cells被引量：129
《Cell Research》2002年第1期9-18,共10页WEI ZHANG, Hui Tu LIU The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China 
supported by the Major StateBasic Research Project (Grant No. G1999053901).
MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPI(families have been characterized: extracellular si...
关键词：MAPK ER.K JNK/SPAK p38 cell proliferation cross-talk. 
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