Polymyxins are a class of last-resort antibiotics used to treat infections caused by multidrug-resistant bacteria. Mobile resistance determinants for polymyxins, including mcr-1 to mcr-10 genes, have previously been r...
supported by the National Key Research and Development Programof China(2019YFC0840600,2019YFC0840609 and 2020YFE0204300);the National Natural Science Foundation of China(82072314);the Zhejiang Province Natural Science Foundation of China(LHDMZ22H190002 and LY19H160060);the Shandong Provincial Laboratory Project(SYS202202);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022011B),the Fundamental Research Funds for the Central Universities(2022ZFJH003);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-045).
It is critical to acknowledge that the coexistence of genes related to carbapenem and polymyxin resistance can exacerbate challenges in antimicrobial therapy.In this study,we identified Klebsiella pneumoniae isolate L...
the National Key Research and Development Program of China(2021YFD1801000 and 2018YFA0903400);the National Natural Science Foundation of China(32222084,32172907,and 32002331);Jiangsu Agricultural Science and Technology Innovation Fund(CX(21)2010);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),and 111 Project D18007.
The emergence of antibiotic tolerance,characterized by the prolonged survival of bacteria following antibiotic exposure,in natural bacterial populations,especially in pathogens carrying antibiotic resistance genes,has...
provided by the National Key Research and Development Program of China(Grant No.2022YFC2303900);along with the National Natural Science Foundation of China(Grant Nos.32141001 and 32225048).
The emergence of mobilized colistin resistance(mcr)genes has raised significant concerns as they pose a public health issue.The prevalence of mcr genes,particularly the newly discovered mcr-9 gene,in non-typhoidal Sal...