MECHANISTIC

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Mechanistic insight on nanomaterial-induced reactive oxygen species formation
《Journal of Environmental Sciences》2025年第5期200-210,共11页Jianzhong Cao Qingchun Wu Xuting Liu Xiangyu Zhu Chunfeng Huang Xinyu Wang Yang Song 
supported by the National Natural Science Foundation of China(No.22176206).
Reactive oxygen species(ROS)are closely related to cell death,proliferation and inflammation.However,excessive ROS levels may exceed the cellular oxidative capacity and cause irreversible damage.Organisms are often in...
关键词：NANOMATERIALS Reactive oxygen species(ROS) TOXICITY MITOCHONDRIA Oxidative stress 
Mechanistic Insights into N-Oleoylethanolamide-Mediated Hepatoprotection via PPAR-α
《BIOCELL》2025年第4期607-627,共21页Darya Ivashkevich Arina Ponomarenko Igor Manzhulo Inessa Dyuizen 
supported by the Russian Science Foundation(project 24-75-00072).
The high prevalence of obesity and associated nonalcoholic fatty liver disease(NAFLD)in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these p...
关键词：NAFLD liver inflammation N-Oleoylethanolamide OEA PPAR-Α 
Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications
《Neural Regeneration Research》2025年第4期1087-1089,共3页Nazaret Gamez Rodrigo Morales 
supported by grants from NIH(RF1AG072491 and R01AI132695)to RM.
Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)patients.Moreover,Aβdeposits have been identified in peripheral tissues.However,the relevance of peri...
关键词：therapeutic AMYLOID latter 
Mechanistic insights into“Three Methods and Three Acupoints”Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats
《Journal of Traditional Chinese Medical Sciences》2025年第1期125-134,共10页Hanyu Zhang Yingqi Zhang Hourong Wang Jiayue Liu Jiawei Sun Jinping Chen Zhifeng Liu Tianyuan Yu Jian Shu 
supported by the National Natural Science Foundation of China(82274675&82074573);the Beijing Natural Science Foundation(7232278).
Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to ...
关键词：Three Methods and Three Acupoints TUINA Spinal cord MICROCIRCULATION PI3K/Akt 
Mechanistic insights into the amelioration effects of diabetic cardiomyopathy by berberine:an integrated systems pharmacology study and experimental validation
《Traditional Medicine Research》2025年第3期42-55,共14页Hui-Min Ji Wen Yang Yu Hua Yi-Xuan Sun Ao-Di Li Yue Jiang Zi-Qi Ye Min Lei Xi-Ying Guo Xiu-Fen Liu Ning-Hua Wu Huan-Bo Cheng Qing-Jie Chen 
supported by the National Natural Science Foundation of China(Grant No.82270892);Natural Science Foundation of Hubei Province(Grant No.2022CFB287);Xianning City Science and Technology Plan Project(Grant No.2022ZRKX052);School projects of Hubei University of Science and Technology(Grant No.2022T01,2021WG05,2021TNB01);Hubei University of Science and Technology School-level Fund(Grant No.BK202122).
Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary a...
关键词：BERBERINE APOPTOSIS integrated systems pharmacology diabetic cardiomyopathy 
Mechanistic insights into the formation of hydroxides with unconventional coordination environments to achieve their cost-effective synthesis
《National Science Review》2025年第3期318-330,共13页Zongkun Chen Qiqi Fan Xingkun Wang Liqun Kang Wenchao Wan Jonathan Thomas Avaro Siyuan Zhang Christina Scheu Jian Zhou Serena DeBeer Saskia Heumann Minghua Huang Heqing Jiang Helmut Cölfen 
supported by the National Natural Science Foundation of China(52261145700 and 22279124);the Taishan Scholars Program of Shandong Province(tstq20221151);the Deutsche Forschungsgemeinschaft(CO 194/19-1);the Max Planck Society for funding.L.K.acknowledges Alexander von Humboldt Foundation for a postdoctoral fellowship and funding support.
Transition metal hydroxides,comprising metal-centered polyhedra,are abundant in nature and have a broad range of applications.Although the intercalation/deintercalation of polyhedra with unconventional coordination nu...
关键词：metal hydroxide formation mechanism in situ characterization coordination geometry oxygen evolution reaction 
Progress of mechanistic pathways involved in electrochemical CO_(2)reduction
《Journal of Energy Chemistry》2025年第3期745-767,共23页Jing-Wen DuanMu Xue-Peng Yang Fei-Yue Gao Masoud Atapour Min-Rui Gao 
financially supported by the National Natural Science Foundation of China(Grants 22225901,21975237 and 51702312);the Fundamental Research Funds for the Central Universities(Grant WK2340000101);the USTC Research Funds of the Double First-Class Initiative(Grant YD2340002007 and YD9990002017);the Open Funds of the State Key Laboratory of Rare Earth Resource Utilization(Grant RERU2022007);the China Postdoctoral Science Foundation(Grants 2023M733371,2024M750006 and 2023T160617);Postdoctoral Fellowship Program(Grade C)of China Postdoctoral Science Foundation(GZC20230008);the Natural Science Foundation Youth Project of Anhui Province(2408085QB065);the Postdoctoral Research Funding Project of Anhui Province(2023B727)。
The electrochemical reduction of carbon dioxide(CO_(2))into value-added chemicals and fuels has been extensively studied as a promising strategy for mitigating environmental issues and achieving sustainable energy con...
关键词：CO_(2)reduction reaction Reaction pathways Faradaic efficiency Catalytic mechanism Cataly ststructure 
Enhancing solid-state lithium metal battery performance via indium-based modification of electrolytes and lithium metal surfaces:mechanistic insights and optimization
《Science China Chemistry》2025年第3期1144-1158,共15页Zhongkai Wu Chen Liu Ziling Jiang Lin Li Siwu Li Chaochao Wei Qiyue Luo Xia Chen Long Zhang Shijie Cheng Chuang Yu 
supported by the National Key Research and Development Program (2021YFB2500200);the National Natural Science Foundation of China (52177214,52222703);The Basic Science Research Fund in Xidian University (ZYTS24132);the Postdoctoral Science Research Program of Shaanxi (30102230001)。
Argyrodite-based solid-state lithium metal batteries exhibit significant potential as next-generation energy storage devices.However,their practical applications are constrained by the intrinsic poor stability of argy...
关键词：Li_(5.5)PS_(4.5)Cl_(1.5)solid electrolyte In_(2)O_(3)dual-doping InF_(3)surface-modification chemical/electrochemical stability electrochemical performance 
Biphasic glucose-stimulated insulin secretion over decades:a journey from measurements and modeling to mechanistic insights
《Life Metabolism》2025年第1期5-15,共11页Xiaohong Peng Kai Wang Liangyi Chen 
the National Center for Protein Sciences at Peking University in Beijing,China;supported by the National Natural Science Foundation of China(81925022,T2288102,and 32227802);the National Key Research and Development Program of China(2022YFC3400600);the Beijing Natural Science Foundation(Z20J00059 and 7244366);the Fundamental Research Funds for the Central Universities(PKU2024XGK011);supported by the New Cornerstone Science Foundation;the High-performance Computing Platform of Peking University.
Glucose-stimulated insulin release from pancreaticβ-cells is critical for maintaining blood glucose homeostasis.An abrupt increase in blood glucose concentration evokes a rapid and transient rise in insulin secretion...
关键词：glucose-stimulated insulin secretion vesicle pools readily releasableβ-cells β-cell heterogeneity 
Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases:Mechanistic insights and therapeutic implications
《World Journal of Cardiology》2025年第2期9-21,共13页Hong-Ni Wang Ye Wang Si-Yao Zhang Lan Bai 
Supported by Ganzhou City’s“Light of the Soviet Area”Talent Project,No.GZSQZG202301009。
Metabolic diseases have emerged as a leading cause of mortality from non-communicable diseases,posing a significant global public health challenge.Al-though the association between ceramides(Cers)and metabolic disease...
关键词：Acid sphingomyelinase CERAMIDE Metabolic and cardiovascular diseases Glycolipid metabolism Inflammation Mitochondrial homeostasis 
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