MEMBRANE_PROTEIN

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相关机构：湖南医科大学中山医学大学中国农业科学院北京畜牧兽医研究所北京大学更多>>
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Cellular Membrane Protein GRINA is Highly Expressed and Associated with Survival Outcomes in Liver Cancer Patients
《Current Medical Science》2025年第1期122-136,共15页Jun-bo Song Shan-shan Guo Wen-jie Gao Zhi-peng Yang Ze-lin Tian 
supported by the National Natural Science Foundation of China(No.82102512).
Objective Hepatocellular carcinoma(HCC),a lethal cancer with high global mortality,may be targeted through ferroptosis,an iron-dependent form of cell death.Despite its potential,the prognostic value of ferroptosis in ...
关键词：Hepatocellular carcinoma Ferroptosis Prognostic signature NOMOGRAM GRINA 
EMP2 promotes hepatocellular carcinoma proliferation and invasion by activating cellular autophagy
《Oncology Research》2025年第2期443-464,共22页HAIYING PANG FENGBO WU YU ZHANG NAN ZHANG CHUNTING WANG QIU LI GU HE PENG ZHANG 
supported by the Fundamental Research Funds for the National Natural Science Foundation of China(Nos.22177084 and 82104373);the Fundamental Research Funds of Science&Technology Department of Sichuan Province(No.2022YFQ0054).
Background:EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family.EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues,...
关键词：Epithelial membrane protein 2 Hepatocellular carcinoma AUTOPHAGY Integrin pathway 
Real-time analysis of nanoscale dynamics in membrane protein insertion via single-molecule imaging
《Biophysics Reports》2024年第6期369-376,共8页Chenguang Yang Dongfei Ma Shuxin Hu Ming Li Ying Lu 
supported by the Guangdong Basic and Applied Basic Research Foundation(2020A1515110102);the National Natural Science Foundation of China(12022409 and T2221001);the CAS Key Research Program of Frontier Sciences(ZDBS-LY-SLH015)。
Membrane proteins often need to be inserted into or attached to the cell membrane to perform their functions.Understanding their transmembrane topology and conformational dynamics during insertion is crucial for eluci...
关键词：Membrane protein INSERT Real time Single molecule NANOSCALE 
Functional characterization of sensory neuron membrane protein 1a involved in sex pheromone detection of Apolygus lucorum(Hemiptera:Miridae)
《Journal of Integrative Agriculture》2024年第12期4120-4135,共16页Yan Li Xingkui An Shuang Shan Xiaoqian Pang Xiaohe Liu Yang Sun Adel Khashaveh Yongjun Zhang 
supported by the National Natural Science Foundation of China(32150410366,31972338,and32372639);the earmarked fund for China Agriculture Research System(CARS-02-26);the National Key Research and Development Program of China(2021YFD1400700);the Special Grant of China Postdoctoral Science Foundation(2022T150712)。
The mirid bug Apolygus lucorum(Hemiptera:Miridae)is a polyphagous pest that affects a wide range of host plants.Its control remains challenging mainly due to its rapid reproduction,necessitating an understanding of se...
关键词：mirid bug pheromone perception sensory neuron membrane proteins expression profile receptor interaction evolution 
SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis
《Acta Biochimica et Biophysica Sinica》2024年第11期1673-1686,共14页Xiyi He Yunfei Zhang Zenghui Mao Gang Liu Lihua Huang Xiaowen Liu Yuyan Su Xiaowei Xing 
This work was supported by the grants from the open research fund of Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control(No.HPKL2023006);the Hunan Provincial Natural Science Foundation of China(No.2023JJ30854);the Natural Science Foundation of Changsha Municipal,Hunan Province,China(No.kq2208354);the Undergraduate and Graduate Student Independent Exploration Innovation Fund of Central South University(Nos.1053320214303 and 1053320215869).
SUN5,a testis-specific gene,is associated with acephalic spermatozoa syndrome(Ass).Here,we demonstrate that SUN5 is involved in mRNA export.In Sun5-knockout mice(Sun5^(-/-)),poly(A)+RNA accumulates in the nuclei of ge...
关键词：SUN5 hnRNPs Nup93 Nxf1 mRNAexport 
Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice被引量：1
《Journal of Genetics and Genomics》2024年第10期1007-1019,共13页Dapeng Zhou Huan Wu Lingbo Wang Xuemei Wang Shuyan Tang Yiling Zhou Jiaxiong Wang Bangguo Wu Jianan Tang Xuehai Zhou Shixiong Tian Shuang Liu Mingrong Lv Xiaojin He Li Jin Hujuan Shi Feng Zhang Yunxia Cao Chunyu Liu 
This study was supported by the National Key Research and Development Program of China(2021YFC2701400 and 2023YFC2705600);the National Natural Science Foundation of China(32288101,32100480,32370654,82271639,32322017,and32200485).
Oligoasthenoteratozoospermia is an important factor affecting male fertility and has been found to be associated with genetic factors.However,there are stll a proportion of oligoasthenoteratozoospermia cases that cann...
关键词：Male fertility OLIGOASTHENOTERATOZOOSPERMIA MFSD6L ACROSOME ICSI 
Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch
《Virologica Sinica》2024年第4期600-608,共9页Jiao Guo Yi Wan Yang Liu Xiaoying Jia Siqi Dong Gengfu Xiao Wei Wang 
supported by the National Key Research and Development Program of China(2023YFC2605504,2022YFC2303300);the National Natural Sciences Foundation of China(82172273 and 31670165);the Open Research Fund Program of the State Key Laboratory of Virology of China(2023JZZD-01);the Health research project of Shaanxi Province(2022D040);the Science and Technology Planning Project of Shaanxi Provincial Education Department(22JK0545);the Natural Science Basic Research Program of Shaanxi(2024JC-YBQN-0922).
Lassa virus(LASV)is an enveloped,negative-sense RNA virus that causes Lassa hemorrhagic fever.Successful entry of LASV requires the viral glycoprotein 1(GP1)to undergo a receptor switch from its primary receptor alpha...
关键词：Lassa virus(LASV) Lysosome-associated membrane protein 1 (LAMP1) GLYCOPROTEIN Receptor switch Membrane fusion 
An orally administered bacterial membrane protein nanodrug ameliorates doxorubicin cardiotoxicity through alleviating impaired intestinal barrier被引量：2
《Bioactive Materials》2024年第7期517-532,共16页Zhen Li Junyue Xing Xiaohan Ma Wanjun Zhang Chuan Wang Yingying Wang Xinkun Qi Yanhui Liu Dongdong Jian Xiaolei Cheng Yanjie Zhu Chao Shi Yongjun Guo Huan Zhao Wei Jiang Hao Tang 
supported by National Natural Science Foundation of China (No.32100093,and 82100294);Natural Science Foundation of Henan Province (No.232300421175);Medical Science and Technology Project of Henan Province (SBGJ202302032);Henan Provincial Joint Fund of Science and Technology Research and Development Program (225200810075);The Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology (Grant 2024HYTP048).
The cardiotoxicity caused by Dox chemotherapy represents a significant limitation to its clinical application and is a major cause of late death in patients undergoing chemotherapy.Currently,there are no effective tre...
关键词：Doxorubicin cardiotoxicity Intestinal barrier Protein delivery Oral nanodrugs Homeostasis of lymphocytes 
Changes in milk fat globule membrane proteins along lactation stage of Laoshan dairy goat
《Journal of Integrative Agriculture》2024年第5期1737-1748,共12页Chuozi Liang Zhongna Yu Guangming Zhu Yixuan Li Xueheng Sun Hongning Jiang Qijing Du Rongbo Fan Jun Wang Yongxin Yang Rongwei Han 
This work was supportedby theNational KeyR&D Program of China(2022YFD1301005);the Shandong Provincial Natural Science Foundation,China(ZR2022MC184);the High-level Talents Foundation of Qingdao Agricultural University,China(665/1120053,665/1120080).
The milk fat globule membrane(MFGM)is a complex structure with numerous functions,and its composition is affected by many factors.There have been few systematic investigations on goat MFGM proteome profiling during la...
关键词：GOAT milk fat globule membrane protein data-independent acquisition(DIA) data-dependent acquisition(DDA) LACTATION PROTEOMICS 
Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents
《World Journal of Pediatrics》2024年第4期353-370,共18页Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau 
the research grants COVID19F12,COVID19F10 and COVID19F02 awarded to LYL by the Health Bureau of the Government of Hong Kong,whilst TIYS was partly supported by a donation in memory of Ton Lung Quong and Reverend Marion Quong;The research work was supported additionally by grants from the Health and Medical Research Fund Commissioned Research on the Novel Coronavirus Disease(COVID-19);Hong Kong SAR(COVID190115)and the Theme-based Research Scheme of the Research Grants Council of the Hong Kong Special Administrative Region,China(T11-712/19-N and T11-705/21-N);The funding sources were not involved in the study design,data collection,laboratory assays,statistical computation,interpretation,or final conclusions of this project.
Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary.Fractional dosing by intradermal(ID)administration has been shown to be equally immunogenic as int...
关键词：CoronaVac Coronavirus disease 2019 Immunity INTRADERMAL Vaccine 
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