supported by grants from the National Natural Science Foundation of China(82025020,82230072 and 32270874);the National Key R&D Program of China(2021YFA1100400 and 2021YFC2701400);the Science and Technology Commission of Shanghai Municipality(21140902300 and 22ZR1464000);Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone(ZJ2018-ZD-004);Medical Research Project of Jing’an District,Shanghai(2023ZX03);Shanghai Municipal Health Commission(202240011);Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai;sponsored by Shanghai Blue Cross Brain Hospital Co.,Ltd.,and Shanghai Tongji University Education Development Foundation.
Organ transplantation is the last-resort option to treat organ failure.However,less than 10%of patients benefit from this only option due to lack of major histocompatibility complex(MHC)-matched donor organs and 25%–...