MICROVESICLE

作品数：18被引量：336H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：李润生赵茹茜杨晓静贾逸敏张辰宇更多>>
相关机构：南京大学南京农业大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《分子诊断与治疗杂志》《Genes & Diseases》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金更多>>
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Tumor-secreted miR-214 induces regulatory T cells： a major link between immune evasion and tumor growth被引量：36
《Cell Research》2014年第10期1164-1180,共17页Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang 
We thank ProfAlexander Rudensky （Memorial Sloan-Kettering Cancer Center, New York） for diphtheria toxin-treated Foxp3DrR mice. We thank Drs Zheng-Gang Liu （Cancer Research Institute, NIH） and Dan Wu （Yale University） for their comments on the manuseirpt. This work was supported by grants from the National Basic Research Program of China （973 Program; 2014CB542300）, the National Natural Science Foundation of China （81101330, 31271378 and 81250044）, the Natural Science Foundation of Jiangsu Province （BK2011013 and BK2012014） and the Research Special Fund for Public Welfare Industry of Health （201302018）. This work was also supported by the program for New Century Excellent Talents in University from the Ministry of Education of China （NCET- 12-0261）.
An increased population of CD4＋CD25highFoxp3＋ regulatory T cells （Tregs） in the tumor-associated microenvi- ronment plays an important role in cancer immune evasion. However, the underlying mechanism remains uncle...
关键词：secreted microRNA regulatory T cell PTEN MICROVESICLE immune evasion TUMOR 
Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF,and the neutralization of miR-150 attenuate tumor development被引量：19
《Protein & Cell》2013年第12期932-941,共10页Yuchen Liu Luming Zhao Dameng Li Yuan Yin Chen-Yu Zhang Jing Li Yujing Zhang 
This work was supported by grants from the National Basic Research Program(973 Program)(No.2014CB542300);the National Natural Science Foundation of China(Grant Nos.31200969,31200874,81101330,31271378,and 81250044);the National Science Fund for Distinguished Young Scholars(81025019);the Natural Science Foun-dation of Jiangsu Province(BK2011013 and BK2012014);the Research Fund for the Doctoral Program of Higher Education of China(20120091120044).
Tumor-associated macrophages(TAMs)mostly exhibit M2-like(alternatively activated)properties and play posi-tive roles in angiogenesis and tumorigenesis.Vascular en-dothelial growth factor(VEGF)is a key angiogenic facto...
关键词：MICROVESICLE miR-150 TUMORIGENESIS VEGF NEUTRALIZATION ATTENUATION 
Moving RNA moves RNA forward被引量：2
《Science China(Life Sciences)》2013年第10期914-920,共7页PENG LiNa LI YuJiao ZHANG Lan YU WenQiang 
supported by the National Basic Research Program of China(2009CB825603,2012CB517605);National Natural Science Foundation of China(81272392)
Cell communication affects all aspects of cell structure and behavior,such as cell proliferation,differentiation,division,and coordination of various physiological functions.The moving RNA in plants and mammalian cell...
关键词：cell communication moving RNA MICROVESICLE 
Exogenous plant MIR168a specifically targets mammalian LDLRAPI： evidence of cross-kingdom regulation by microRNA被引量：167
《Cell Research》2012年第1期107-126,共20页Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang 
We thank Dr Daniel Wu （Yale University, USA） and Dr Zheng- Gang Liu （Cancer Research Institute, NIH, USA） for critical reading of the manuscript and discussion of data. This work was supported by grants from the National Natural Science Foundation of China （90813035, 30890044, 30771036, 30772484, 30725008, 30890032, 31071232, 31000323, and 90608010）, the National Basic Research Program of China （973 Program 2006CB503909, 2007CB815701, 2007CB815703, 2007CB815705, and 2007CB815804; 863 Program 2006AA02Z177 and 2006AA10A121）, and the Natural Science Foundation of Jiangsu Province （BK2008021）.
Our previous studies have demonstrated that stable microRNAs （miRNAs） in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as ...
关键词：MICRORNA MIR168a LDLRAP1 low-density lipoprotein MICROVESICLE cross-kingdom 
一种细胞间通信的新的信号分子——Microvesicle运输的microRNA被引量：5
《分子诊断与治疗杂志》2010年第6期417-423,共7页梁宏伟 陈熹 曾科 张辰宇 
国家重点基础研究发展计划(973计划)(2006CB503909);国家自然科学基金(30950100)
Microvesicle（MV）是机体内的细胞在正常和病理状态下都会分泌的直径在30~1000nm之间的微小囊泡。细胞把特异的生物活性分子如蛋白质、mRNA等包裹到MV中，这些生物活性分子会通过MV被运输到相应的受体细胞以调节受体细胞的生物功能。...
关键词：MICROVESICLE MICRORNA 细胞间通信 外泌体 
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