the National Natural Science Foundation of China(No.30970706,81700784,81974145);the Fundamental Research Funds for the Central Universities(China)(No.D5000210746);the Key Research and Development Project of Shaanxi Province(China)(No.2021SF-293,2021SF-242);the Talent Introduction Project of Sichuan University of Science and Engineering(No.2022RC01);the Guangdong Basic and Applied Basic Research Foundation(China)(No.2023A1515030047).
Tooth mineralization is a ubiquitous and tightly regulated process involving complicated interactions between dental epithelium and mesenchyme.Key molecules in tooth mineralization remain poorly identified.Microtubule...
supported by the National Key Research and Development Program of China(2023YFB3813000);the National Natural Science Foundation of China(T2121004,92268203,32371411).
Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstand...
supported by Beijing Natural Science Foundation(L212010);the National Natural Science Foundation of China(T2125003,52372174);the New Cornerstone Science Foundation,Major Instrument Project of the National Natural Science Foundation of China(22027810);the National Key Research and Development Program of China(2022YFB3804703,2022YFE0111700,2021YFA1200900,2021YFB3201204,2022YFB3205602)。
Orderly hierarchical structure with balanced mechanical,chemical,and electrical properties is the basis of the natural bone microenvironment.Inspired by nature,we developed a piezocatalytically-induced controlled mine...
The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo trials.However,there were studies indicating negative effects of high dose Mg intake and susta...
supported by National Natural Science Foundation of China (31971326);Science and Technology Project of Suzhou (ZXT2022007).
Bone fractures are common occurrence in clinical settings,creating a high demand for effective repair material.Unfortunately,limited graft availability,donor site morbidities,unpredictable clinical outcomes,immunologi...
supported by the National Natural Science Foundation of China(No.82073799);the Natural Science Foundation of Hunan Province in China(2021JJ20084);the Science and Technology Innovation Program of Hunan Province in China(2021RC3020).
Autologous cancer vaccine that stimulates tumor-specific immune responses for personalized immunotherapy holds great potential for tumor therapy.However,its efficacy is still suboptimal due to the immunosuppressive tu...
supported by the National Natural Science Foundation of China (Grant numbers 11932014 and 31971239);the Sichuan Science and Technology Program (Grant numbers 2022NSFSC0765 and 2022ZYD0079)。
Matrix vesicles(MVs)have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle cha...
funded by National Natural Science Foundation of China(Grant No.82001094 and 21905094);Guangzhou Science and Technology Program(Grant No.202102020519 and 202201010912);Guangdong Financial Fund for High-Caliber Hospital Construction(Grant No.174-2018-XMZC-0001-03-0125/D-20);Open Funding of Guangdong Provincial Key Laboratory of Stomatology(No.KF2022120104);Guangdong Basic and Applied Basic Research Foundation(Grant No.2019A1515110379 and 2021A1515010782).
Lamellar bone,compactly and ingeniously organized in the hierarchical pattern with 6 ordered scales,is the structural motif of mature bone.Each hierarchical scale exerts an essential role in determining physiological ...
The authors regret the incorrect publication of Fig.5,which was not identified during the proofing stage.During a self-check,we unfortunately found that the insets(250μg/mL,1 day)in Fig.5b/c and the image(1000μg/mL,...
National Natural Science Foundation of China(General Program),No.31870971;Medical Health Science and Technology Project of Zhejiang Province,No.2023KY155.
BACKGROUND Accumulating evidence suggests that the maxillary process,to which cranial crest cells migrate,is essential to tooth development.Emerging studies indicate that Cd271 plays an essential role in odontogenesis...