supported, in part, Jiangsu UniversityScience Research Project (17KJD310001, S.G.);National Science Foundation in China 816280007(J.H.H. and F.W.);Jiangsu Specially Appointed Professorship Foundation (F.W.);Jiangsu Nature Science FoundationBK20151565 (F.W.);Jiangsu Traditional Chinese Medicine Foundation ZD201501 (F.W.);Jiangsu Six TalentPeak project 2015YY006 (F.W.);the priority academic program development of Jiangsu Higher Education Institute (Integrated Chinese and Western Medicine)~~