云南高校图书馆联盟文献共享服务平台- 袁霞

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Effects and mechanism of proteasome inhibitor YSY01--A alone or in combination with cisplatin against A549 cells in vitro被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2015年第9期607-616,共10页孙婷袁霞黄薇郭维葛泽梅李润涛崔景荣; Eleventh Five-Year Plan for National Science and Technology Major Project(Grant No.2009ZX0930010);National Science Foundation of China(Grant No.81172915);a grant from Major New Drug Research and Development Platform of Peking University(GrantNo.2009ZX09301010); YSY01-A, as a novel proteasome inhibitor, has shown remarkable proliferation inhibitory effect on certain types of tumor cells. However, few studies have reported its effect on non-small cell lung cancer （NSCLC）, an...; 关键词：Proteasome inhibitor A549 Cisplatin combination PTEN CTR1 ANTITUMOR

Effects of compound YSY-01A, a novel proteasome inhibitor, on MGC-803 cells and its related mechanism: 《Journal of Chinese Pharmaceutical Sciences》2014年第9期601-609,共9页陈溢欣袁霞葛泽梅冉福香吴军李润涛崔景荣; Eleventh Five-Year Plan for National Science and Technology Major Project(Grant No.2009ZX0930-010);National Science Foundation of China(Grant No.81172915);a grant from Major New Drug Research and Development Platform of PekingUniversity(Grant No.2009ZX09301-010); As a novel proteasome inhibitor, remarkable proliferation inhibitory effect of compound YSY-01A was shown on tumor cells in previous studies. However, few studies has reported its effect on gastric cancer and related ...; 关键词：Proteasome inhibitor YSY-01A MGC-803 cell line NF-KB ANTI-TUMOR

A new proteasome inhibitor YSY-01A induced autophagy in PC-3M cells被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2014年第8期565-571,共7页王喆袁霞葛泽梅冉福香吴军李润涛崔景荣; Eleventh Five-Year Plan for National Science and Technology Major Project(Grant No.2009ZX0930-010);National Science Foundation of China(Grant No.81172915);a grant from Major New Drugs Research and Development Platform of Peking University(Grant No.2009ZX09301-010); YSY-01A has shown proliferation inhibitory activity to certain types of tumor cells by inhibiting proteasome. How- ever, its effect on autophagy, which is related with the ubiquitin proteasome pathway （UPP）, remains...; 关键词：Proteasome inhibitor YSY-01 A PC-3M AUTOPHAGY

蛋白酶体抑制剂YSY01A不依赖NF-κB通路抑制乳腺癌细胞增殖及诱导凋亡研究被引量：2: 《中国药理学通报》2014年第3期34-39,共6页张梅袁霞徐波冉福香吴军葛泽梅李润涛崔景荣; 国家科技部"重大新药创制"科技专项基金(No2009ZX0930010);国家自然科学基金资助项目(No81172915); 目的研究YSY01A对乳腺癌的增殖抑制作用及其抗癌机制。方法荧光底物法检测蛋白酶体活性;蛋白酶体荧光探针法研究YSY01A与蛋白酶体β催化亚基结合;Annexin V-FITC、JC-1探针检测YSY01A对细胞凋亡和线粒体膜电位的影响;用蛋白免疫印迹法...; 关键词：蛋白酶体抑制剂增殖凋亡 NF-ΚB 乳腺癌

DNA damaging effect of SLXM-2, a derivative of cyclophosphamide, on hepatocarcinoma H_(22) cells in vivo: 《Journal of Chinese Pharmaceutical Sciences》2014年第1期16-21,共6页楚明明袁霞贾璇孙婷郭维蒋晓刘敬弢李润涛崔景荣; Eleventh Five Year Plan for National Science and Technology Major Project(Grant No.2009ZX0930010); Compound SLXM-2, a derivative of cyclophosphamide （CTX）, has shown potent growth-inhibitory effect on tumor cells with low toxicity in previous studies. However, the mechanism of its anti-tumor effect, especially on...; 关键词：SLXM-2 H22 DNA damage SCGE DNA damage-related proteins

新型蛋白酶体抑制剂YSY-01A对肿瘤细胞促血管生成作用的抑制及其机制初探被引量：11: 《生物化学与生物物理进展》2013年第8期748-756,共9页刘敬弢袁霞徐波冉福香楚明明贾璇陈溢欣王哲李润涛崔景荣; 国家“十一五”科技重大专项:北京大学综合性创新药物研究开发技术大平台(2009ZX09301-010)~~; YSY-01A是一种新型蛋白酶体抑制剂,前期研究已经证实其对肿瘤细胞的增殖有抑制作用.但是它对肿瘤血管生成是否有影响尚不明确.本研究旨在探明YSY-01A阻碍肿瘤细胞促进血管生成的作用及机制.我们首先将磺酰罗丹明B(sulforhodamine B,SRB...; 关键词：蛋白酶体抑制剂血管生成人脐静脉内皮细胞 HT-29细胞高内涵筛选 YSY-01A

Cell cycle arrest effect of compound YSY-01A, a new proteasome inhibitor,on SK-OV-3 cells被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2013年第6期483-490,共8页贾璇袁霞楚明明冉福香李润涛崔景荣; Eleventh Five-Year Plan for National Science and Technology Major Project(Grant No.2009ZX0930-010);National Science Foundation of China(Grant No.81172915);a grant from Major New Drugs Research and Development Platform of Peking University(Grant No.2009ZX09301-010); Compound YSY-01A, a recently synthesized proteasome inhibitor, has shown potent growth-inhibitory effect on tumor cells in previous researches. However, the mechanism of its inhibitory effects, especially on cell cycl...; 关键词：Proteasome inhibitor YSY-01A SK-OV-3 Cell-cycle related protein High content screening

Effects of compound 209 on colorectal cancer cell HT-29 in vivo and in vitro: 《Journal of Chinese Pharmaceutical Sciences》2013年第1期89-94,共6页蒋晓袁霞楚明明郭维刘敬弢冉福香葛泽梅李润涛崔景荣; China International Science and Technology Cooperation Program for Key Projects (Grant No. 2008DFA31070); Compound 209 is a newly synthesized dithiocarbamate derivative with antiproliferation activity in vitro, however, its antitumor effect in vivo and the underlying mechanisms have yet to be identified. We explored the a...; 关键词：DITHIOCARBAMATE Compound 209 Cell cycle Cell cycle-related proteins HT-29 cell line

Cell cycle arrest effect of compound YSY-01A, a new proteasome inhibitor, on HT-29 cells in vitro被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2012年第5期448-458,共11页佟侃刘敬弢袁霞徐波郭维韩利强姚书扬葛泽梅李润涛崔景荣; Eleventh Five-Year Plan for National Science and Technology Major Project (Grant No.2009ZX0930-010);National Science Foundation of China (NSFC81172915);A grant from Major New Drugs Research and Development Platform of Peking University (Grant No.2009ZX09301-010); Compound YSY-01A, a recently synthesized proteasome inhibitor, has shown potent growth-inhibitory effect on tumor cells in previous researches. However, the mechanism of its inhibitory effects, especially on cell cycl...; 关键词：Proteasome inhibitor YSY-01A HT-29 Cell-cycle related protein HCS

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