supported by the Natural Science Foundation of China(No.31101241);the Natural Science Foundation of Shandong Province,China(No.Q2007C13);the Shandong Administration of Traditional Chinese Medicine(No.2009-152);the Independent Innovation Foundation of Shandong University(IIFSDU,No.2012TS163)~~
目的:建立快速测定大鼠血浆中脱水葛根素浓度的液相色谱-串联质谱分析方法,并探讨脱水葛根素在大鼠体内的药代动力学。方法:血浆样品加入甲醇沉淀蛋白后,用LC-MS/MS进行测定分析。色谱柱为Zorbax SB-C18column(4.6 mm×150 mm I.D.5.0μ...