李健

作品数：4被引量：2H指数：1
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供职机构：北京大学药学院药剂学系更多>>
发文主题：LC-MS/MSPHARMACOKINETICSNUDE_MICEPLASMALIQUID_CHROMATOGRAPHY更多>>
发文领域：医药卫生理学更多>>
发文期刊：《Journal of Chinese Pharmaceutical Sciences》更多>>
所获基金：国家自然科学基金更多>>
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A highly sensitive LC-MS/MS method for the determination of 21-hydroxy deflazacort in nude mice plasma and its application to a pharmacokinetic study
《Journal of Chinese Pharmaceutical Sciences》2017年第6期404-412,共9页姚庆宇 李健 姚烨 陈镕 陈文君 苏红 杨亮 薛钧升 卢炜 周田彦 
National Natural Science Foundation of China(NSFC,Grant No.81673500)
In the current study, we established and validated a simple and sensitive liquid chromatography-tandem mass spectrometric method for the determination of 21-hydroxy deflazacort in nude mice plasma, and such a method w...
关键词：DEFLAZACORT 21-Hydorxy deflazacort LC-MS/MS Nude mice PHARMACOKINETICS 
A liquid chromatography-tandem mass spectrometric method for the determination of axitinib in nude mouse plasma: development, validation and application to a pharmacokinetic study被引量：1
《Journal of Chinese Pharmaceutical Sciences》2016年第5期342-350,共9页马元亨 李健 苏清虹 陈文君 卢炜 周田彦 
National Natural Science Foundation of China(NSFC,Grant No.81473277)
In the present study, a simple, rapid, and sensitive liquid chromatography-tandem mass spectrometric method for the determination of axitinib in nude mouse plasma was developed, validated, and applied to a pharmacokin...
关键词：AXITINIB LC-MS/MS Nude mice PHARMACOKINETICS 
Simultaneous determination of sunitinib and its active metabolites N-desethylsunitinib(SU12662) in nude mice plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study被引量：1
《Journal of Chinese Pharmaceutical Sciences》2015年第4期217-224,共8页李静云 李健 王思媛 袁茵 苏青虹 卢炜 周田彦 
National Natural Science Foundation of China(NSFC,Grant No.81473277)
A sensitive, rapid, and simple liquid chromatography tandem mass spectrometry（LC-MS/MS） method for simultaneous determination of sunitinib and its active metabolites in plasma of BABL/c nude mice was developed and v...
关键词：LC-MS/MS Sunitinib SU12662 Nude mice Pharmacokinetics 
Comparison of dopamine with levodopa in the induction of aryl sulfotransferases and estrogen sulfotransferase in rat liver
《Journal of Chinese Pharmaceutical Sciences》2014年第7期471-479,共9页邵雪岩 李健 王思媛 陈广平 许娇娇 冀希炜 李良 卢炜 周田彦 
National Natural Science Foundation of China(Grant No.81072699)
Sulfotransferases（SULTs） are one of the most important phase II drug-metabolizing enzymes. Among them, aryl sulfotransferases（SULT1A1） and estrogen sulfotransferase（EST, SULT1E1） belong to the rSULT1 family that...
关键词：DOPAMINE LEVODOPA Dopamine receptors SULFOTRANSFERASE INDUCTION 
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