supported by the National Natural Science Foundation of China(91953202,31930060,and 31870744);the CAS Strategic Priority Research Program(XDB37030104);the National Science Fund for Distinguished Young Scholars(32022038);the National Key Research and Development Program of China(2018YFA0507000);the Shanghai Rising-Star Program(20QA1406500);the Shanghai Science and Technology Plan(21DZ2260400);the Shanghai Municipal Government and ShanghaiTech University for financial support;supported by Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University。