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Population-scale genetic control of alternative polyadenylation and its association with human diseases
《Quantitative Biology》2022年第1期44-54,共11页Lei Li Yumei Li Xudong Zou Fuduan Peng Ya Cui Eric J.Wagner Wei Li 
support from the National Institutes of Health grant R01-GM134539(EJ.W).
Background:Genome-wide association studies(GWAS)have identified thousands of genomic non-coding variants statistically associated with many human traits and diseases,including cancer.However,the functional interpretat...
关键词：GWAS EQTL DISEASE alternative polyadenylation 
Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat被引量：26
《Molecular Plant》2022年第2期276-292,共17页Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang 
supported by grants from the National Natural Science Foundation of China(31701418 and 32072002);the Natural Science Basic Research Plan in Shaanxi Province of China(2019JCW-18);and the 111 Project from the Ministry of Education of China(B07049).
Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic co...
关键词：wheat(Triticum aestivum) drought tolerance GWAS TaNAC071-A cis-regulatory element transcrip-tional regulation 
Immunogenetic basis of chicken’s heterophil to lymphocyte ratio revealed by genome-wide indel variants analysis
《Journal of Integrative Agriculture》2023年第9期2810-2823,共14页ZHANG Jin WANG Jie WANG Qiao CUI Huan-xian DING Ji-qiang WANG Zi-xuan Mamadou Thiam LI Qing-he ZHAO Gui-ping 
supported by the grants from the National Natural Science Foundation of China(32072708);the National Key R&D Program of China(2018YFE0128000);the Major Scientific Research Projects of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202005).
Enhancing host immunity is an effective way to reduce morbidity in chickens.Heterophil to lymphocyte ratio(H/L)is associated with host disease resistance in birds.Chickens with different H/L levels show different dise...
关键词：H/L ratio heterophil INDEL selective sweep GWAS 
First genome-wide association study of 99 body measures derived from 3-dimensional body scans
《Genes & Diseases》2022年第3期777-788,共12页Andreas Kuhnapfel Peter Ahnert Katrin Horn Holger Kirsten Markus Loeffler Markus Scholz 
This work was supported by the Federal Ministry of Education and Research,Germany(No.01E01501.AD2-7117 to MS).
Body height,body mass index,hip and waist circumference are important risk factors or outcome variables in clinical and epidemiological research with complex underlying genetics.However,these classical anthropometric ...
关键词：3D-anthropometry Genetic correlation GWAS HERITABILITY PheWAS 
GWAS在妇科肿瘤中的应用与前景被引量：1
《现代妇产科进展》2011年第8期656-659,共4页卢聪 万小平 
国家自然科学基金面上项目(No:3087276081072139)
全基因组关联分析(GWAS)提供了一种强有力的方法以鉴定常见的、低外显率的疾病敏感位点,在事先不知其表型及功能的情况下。在过去的5年里,已经有超过700例GWAS成功地实施并发表,其中有3例与妇科肿瘤有关。在GWAS检测出的敏感基因中,大...
关键词：GWAS 单核苷酸多态性 上皮性卵巢癌 敏感等位基因 
小麦耐低磷相关性状的全基因组关联分析被引量：15
《植物遗传资源学报》2020年第2期431-441,共11页周思远 毕惠惠 程西永 张旭睿 闰永行 王航辉 毛培钧 李海霞 许海霞 
国家重点研发计划(2017YFD0100706);转基因生物新品种培育重大专项(2016ZX08002003-004)。
通过对小麦耐低磷相关性状进行全基因组关联分析(GWAS,genome-wide association study),挖掘与小麦耐低磷性显著相关的单核苷酸多态性标记(SNP,single nucleotide polymorphism)位点及候选基因,为小麦耐低磷性状的遗传基础和分子机制研...
关键词：小麦 耐低磷相关性状 全基因组关联分析 SNP 候选基因 
Analyzing the genomic and transcriptomic architecture of milk traits in Murciano-Granadina goats
《Journal of Animal Science and Biotechnology》2020年第3期649-666,共18页Dailu Guan Vincenzo Landi María Gracia Luigi-Sierra Juan Vicente Delgado Xavier Such Anna Castelló Betlem Cabrera Emilio Mármol-Sánchez Javier Fernández-Alvarez JoséLuis Ruiz de la Torre Casañas Amparo Martínez Jordi Jordana Marcel Amills 
funded by the European Fund for Regional Development/Ministerio de Ciencia,Innovación y Universidades-Agencia Estatal de Investigación/Project Reference AGL2016–76108-R;We acknowledge the financial support from the Spanish Ministry of Economy and Competitiveness,through the“Severo Ochoa Programme for Centres of Excellence in R&D”2016–2019(SEV-2015-0533);from the CERCA programme of the Generalitat de Catalunya.Dailu Guan was funded by a PhD fellowship from the China Scholarship Council(CSC);Maria Luigi-Sierra was funded with a PhD fellowship“Formación de Personal Investigador”(BES-C-2017-0024)awarded by the Spanish Ministry of Economy and Competitivity;Emilio Mármol-Sánchez was funded with a PhD fellowship(FPU15/01733)awarded by the Spanish Ministry of Education and Culture(MECD).
Background:In this study,we aimed to investigate the molecular basis of lactation as well as to identify the genetic factors that influence milk yield and composition in goats.To achieve these two goals,we have analyz...
关键词：Casein genes Dairy traits GWAS LACTATION QTLS RNA-Seq 
芥菜型油菜苗期氮效率相关性状全基因组关联分析
《中国农业科学》2023年第20期3946-3959,共14页曾健 王茹梦 龚盼 杨潇 尹晓奇 李江鹤 陈世龙 姚蕾 宋海星 康雷 张振华 
国家自然科学基金联合基金重点项目(U21A20236);国家自然科学基金面上项目(32072664);湖南省科技创新领军人才项目(2022RC3053);湖南省自然科学基金杰出青年基金(2021JJ0004)。
【目的】通过对芥菜型油菜苗期氮效率相关性状进行全基因组关联分析,挖掘与油菜氮效率相关性状显著关联的SNP位点,预测相关候选基因,为揭示油菜氮高效分子机制和创制氮高效种质提供理论依据。【方法】以153份芥菜型油菜品系作为关联群体...
关键词：芥菜型油菜 氮效率相关性状 全基因组关联分析 候选基因 
大豆种子蛋白和油脂含量调控的研究进展被引量：2
《热带亚热带植物学报》2022年第6期791-800,共10页刘虹洁 王金星 刘昭军 刘书 侯兴亮 李晓明 
国家自然科学基金项目(31871643,31801390);广东省植物适应性与分子设计重点实验室项目(2022B1212010013-3);海南省崖州湾种子实验室项目(B21HJ0110)资助。
作为重要的粮油饲兼用作物,大豆为世界膳食提供高达约71%的蛋白质和29%的油脂。随着人口不断增长和大豆消费需求的不断提高,在有限的耕地面积和单产条件下,大豆品质的遗传改良则更具重要意义。该文综述了大豆种子蛋白和油脂含量两个重...
关键词：蛋白含量 油脂含量 关键酶 转录因子 QTL GWAS 
蛋鸡资源群体的小肠质量全基因组关联分析
《江苏农业科学》2022年第22期165-170,共6页李永峰 王克华 窦套存 胡玉萍 郭军 王星果 马猛 曲亮 
江苏省种业振业揭榜挂帅项目(编号:JBGS[2021]104);江苏省农业重大新品种创制(编号:PZCZ201729);现代农业产业技术体系建设专项(编号:CARS-40-K01)。
小肠是鸡重要的营养消化吸收器官,在蛋鸡生长和生产发挥重要作用,小肠质量是反映肠道发育情况的重要生理指标,有必要对其遗传结构进行研究。利用白来航鸡与东乡绿壳蛋鸡杂交构建F_(2)代资源群体,采用600K鸡SNP芯片对F_(2)代1512羽个体...
关键词：蛋鸡 小肠质量 GWAS 遗传结构 
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